Ultrasonic enhancement of nitrogen mustard cytotoxicity in mouse leukemia

Kremkau, Frederick W.; Kaufmann, John S.; Walker, Mary; Burch, Patrick G.; Spurr, Charles L.

doi:10.1002/1097-0142(197604)37:4<1643::aid-cncr2820370404>3.0.co;2-l

Cited by 62 publications

(30 citation statements)

References 5 publications

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“…Several reports have reveled ultrasound is able to enhance the anticancer effect of some chemotherapeutic drugs. Kremkau et al also found that ultrasound irradiation could potentiate the cytotoxic effect of various drugs, such as nitrogen mustard, in murine leukemia L1210 cells [4]. Similar results have been obtained from the experiments performed by Harrison and Balcer-Kubiczek [5].…”

Section: Introductionsupporting

confidence: 61%

Comparison of cell membrane damage induced by the therapeutic ultrasound on human breast cancer MCF-7 and MCF-7/ADR cells

Jia

Yuan

Zhang

et al. 2015

Ultrasonics Sonochemistry

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Section: Introductionsupporting

confidence: 61%

Comparison of cell membrane damage induced by the therapeutic ultrasound on human breast cancer MCF-7 and MCF-7/ADR cells

Jia

Yuan

Zhang

et al. 2015

Ultrasonics Sonochemistry

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“…Mice subsequently inoculated with these cells had longer survival times than control animals that received cells exposed to the drug but not ultrasound. [27]…”

Section: Discussion and Resultsmentioning

confidence: 99%

Prospective utility of therapeutic ultrasound in dentistry-Review with recent comprehensive update

et al. 2012

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Background:The utility of ultrasound (US) for therapeutic purposes is still in its infancy. Therapeutic US (TUS) has been used widely in medical field for urological application, surgical intervention, bone healing, and osteointegration in cancer and healing of full thickness excised skin lesions, and within dentistry as a prediagnostic, diagnostic and therapeutic purpose. The purpose of the paper is to review and determine the efficacy of US as one of the treatment modalities for its role in maxillofacial region to reduce pain and promote soft tissue healing.Materials and Methods:A Medline search included of the international literature published between 1976 and 2011 and was restricted to English language articles, published work of past researchers including in vitro and in vivo studies, recent additions of textbooks on surgical and therapeutic applications of US and, current articles in conference papers and reports accessed from the internet using Google search engine on therapeutic ultrasound.Results:Very few article regarding effect of therapeutic of US for its use of insonation for treatment of patient with pain and soft tissue injury are available. This review article mainly emphasizes the therapeutic utility of US in dentistry for its effectiveness to decrease joint stiffness, reduce pain and muscle spasms and improve muscle mobility. In vivo studies have shown very little clinical effects.Conclusions:Further research is warranted in this clinically important area to make the development of noninvasive, multifunctional ultrasound devices for repair, regeneration and other therapeutic utility a success.

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“…The cytotoxic effect of nitrogen mustard on mouse leukemia L1210 cells after sonication without any mechanical damage to cells was observed (Kremkau et al 1976). Tumors implanted into the hamster flank and sonicated with the co-administration of a chemotherapeutic (BCNU) improved the survival rate from 29.4% (sonication alone) to 40% (Fry and Johnson 1978).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Small Molecule Delivery by Pulsed High-Intensity Focused Ultrasound: A Parameter Exploration

Zhou

Wang

Farr

et al. 2016

Ultrasound in Medicine & Biology

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Chemotherapeutic drug delivery is often ineffective within solid tumors, but increasing the drug dose would result in systemic toxicity. The use of high-intensity focused ultrasound (HIFU) has the potential to enhance penetration of small molecules. However, operation parameters need to be optimized before the use of chemotherapeutic drug in vivo and translation to clinical trial. In this study, the effects of pulsed-HIFU (pHIFU) parameters (spatial-average pulse-average intensity, duty factor, and pulse repetition frequency) to the penetration as well as content of small molecules were evaluated in ex vivo porcine kidneys. Specific HIFU parameters resulted in over 40 times greater Evans blue content and 3.5 times the penetration depth compared to untreated samples. When selected parameters were applied to porcine kidneys in vivo, a 2.3-fold increase in concentration was obtained after a 2-minute pHIFU exposure. Altogether, pHIFU has shown to be an effective modality to enhance both the concentration and penetration depth of small molecules into tissue using the optimized HIFU parameters. Although, performed in normal tissue, this study has the promise of translation into tumor tissue.

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Ultrasonic enhancement of nitrogen mustard cytotoxicity in mouse leukemia

Cited by 62 publications

References 5 publications

Comparison of cell membrane damage induced by the therapeutic ultrasound on human breast cancer MCF-7 and MCF-7/ADR cells

Comparison of cell membrane damage induced by the therapeutic ultrasound on human breast cancer MCF-7 and MCF-7/ADR cells

Prospective utility of therapeutic ultrasound in dentistry-Review with recent comprehensive update

Enhancement of Small Molecule Delivery by Pulsed High-Intensity Focused Ultrasound: A Parameter Exploration

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