Ultrasonic extraction and purification of scutellarin from Erigerontis Herba using deep eutectic solvent

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

“…with advantages of being used at milder temperatures without flammable solvents and lower extraction times [ 164 , 165 ]. Liu et al [ 166 ] screen twenty-seven DESs combined with UAE to retrieve scutellarin from Erigerontis Herba , an herb used in Chinese medicine. From the DESs screened, twenty-five had a higher extraction yield than the conventional solvents (methanol and 75% ethanol solution).…”

“…The extraction performance is enhanced when the DESs are used in conjunction with UAE. In these cases, there is a synergetic effect between the cavitation phenomenon of the ultrasound and the ability of the DESs to bond to the target molecules [ 166 , 177 , 178 ].…”

“…The DESs were reused at least three times without loss of extraction yield [ 187 ]. The anti-solvent method was also used by Liu et al [ 166 ] to recover 71.7% of scutellarin after the DES extraction. Biphasic systems were also developed to separate the DESs from the extracts.…”

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

“…with advantages of being used at milder temperatures without flammable solvents and lower extraction times [169,170]. Liu et al [171] screen twenty-seven DESs combined with UAE to retrieve scutellarin from Erigerontis Herba, an herb used in Chinese medicine. From the DESs screened, twenty-five had a higher extraction yield than the conventional solvents (methanol and 75% ethanol solution).…”

Green and highly effective extraction of bioactive flavonoids from Fructus aurantii employing deep eutectic solvents-based ultrasonic-assisted extraction protocol

“…Deep eutectic solvents (DESs), a breakthrough environmentally benign solvent that has the potential to replace organic solvents, have been receiving considerable attention in recent years [11] , [12] , [13] . Usually, hydrogen bond donors (HBDs) and acceptors (HBAs) are combined and heated in the proper mole ratio to create DESs, which then react based on hydrogen bond interaction [11] , [12] , [13] , [14] , [15] . In comparison with conventional organic solvents, DESs are not only non-toxicity, inexpensive in cost, environmental friendliness, biodegradable, nonflammable and stable, but they also have a series of benefits including quick and easy synthesis, availability and high-efficiency [16] , [17] , [18] , [19] , [20] , [21] , [22] .…”