Ultrasonic freezing of polymers of various compositions before freeze drying: Effect of ultrasound on freezing kinetics and ice crystal size

Mokhova, Elizaveta; Гордиенко, М. Г.; Menshutina, Natalia; Gurskiy, Igor; Творогова, А. А.

doi:10.1080/07373937.2023.2173226

Cited by 4 publications

(4 citation statements)

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“…To implement freezing with the use of ultrasound, an installation was assembled that allows the sonocrystallization process to be carried out to obtain smaller and more uniform ice crystals in the polymers under study. A detailed description of the installation and the mode of ultrasonic freezing were presented in our previous study [32]. Therefore, these aspects will not be presented in detail in this paper.…”

Section: Methods For Obtaining Solutions Of Polysaccharides and Matri...mentioning

confidence: 99%

“…To study the structure and analyze the effect of ultrasound on the morphology of ice crystals formed during the freezing of polymer solutions, an Olympus CX 41 light microscope with a camera and a PE 120 cooling stage (limiting cooling temperature −18 • C) was used. A detailed description of the research methodology was presented in our previous work [32].…”

Section: Study Of the Structure Of Ice Crystalsmentioning

confidence: 99%

“…This technological process is divided into several main stages: preliminary freezing and the first and second drying periods. In our previous study [32], we considered the effect of ultrasound on the freezing kinetics of polymers of various natures and the size distribution of ice crystals. However, the study, analysis and comparison of a set of properties of polysaccharides and materials based on them, subjected to physical and mechanical influences in the stage of preliminary freezing, is also an urgent task.…”

Section: Introductionmentioning

confidence: 99%

“…The use of ultrasound during the stage of freezing materials allows one to influence the shape of ice crystals and their direction; in accordance with this, materials of anisotropic shape can be obtained. Ultrasound is also capable of acting on the vibrational spectra of molecules and intensifying heat and mass transfer at the freezing stage [32]. The study of these aspects can contribute to the development of both theoretical and practical knowledge about the relationship between the structure and properties of the obtained materials, as well as accelerate the development of materials with different structure and direction of pores and expand their areas of application.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Ultrasound on the Properties of Polysaccharide Complexes and Materials Based on Them

et al. 2023

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Freeze-drying is often used as a final stage to produce three-dimensional porous matrices for medicine. Because a pure solvent crystallizes first during freezing, it acts as a pore-forming agent. The size of the solvent crystals primarily depends on the cooling rate and the composition of the material to be frozen. Ultrasonic treatment also affects the size of crystals and can be used to control the structure of a porous matrix. This article describes the effect of ultrasound (40 kHz, 50 W) applied at the preliminary freezing stage of polysaccharide solutions (alginate, chitosan, alginate–chitosan and alginate–gelatin) on the finished matrix properties. The most attention was paid to the effect of ultrasound on the size and shape of crystals formed during freezing, which leads to a change in the porous structure of the matrices after solvent sublimation. As a result of changes in the microstructure, a number of differences in the vibrational spectra of the molecules and the values of pore volume, sorption capacity, permeability and degradation of matrices were identified. Such changes in the structure of materials, as well as the emerging directionality of pores, together can affect the process of cell cultivation in these polysaccharide matrices, which can be useful in solving problems of tissue engineering.

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Section: Methods For Obtaining Solutions Of Polysaccharides and Matri...mentioning

confidence: 99%

Section: Study Of the Structure Of Ice Crystalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations