Ultrasonic Interfacial Engineering of MoS₂‐Modified Zn Single‐Atom Catalysts for Efficient Osteomyelitis Sonodynamic Ion Therapy

Abstract

sepsis. Nearly 40% Patients suffered from bone infection have the risk of recurrence and chronic infection. [3] Clinical treatments for osteomyelitis involve the long-term and high-dose antibiotics administration, as well as multiple surgical debridement. [4] However, the notable problems of these approaches are obvious. The overuse of antibiotics not only brings severe side effects, but also causes drug-resistant. [5] The removed bone tissue by debridement will weaken the musculoskeletal support and lead to unaesthetic disfigurements. [1] Recent studies showed that controlling antibiotic delivery from nanoparticles or hydrogels could improve the antibacterial efficiency and reduce the dosage of antibiotics, however, superbugs infection still cannot be eliminated efficiently. [6] Given these obstacles, using an antibiotics-free, in situ, and rapid strategy to treat drugresistance bacteria induced osteomyelitis is highly desirable. Photodynamic and photothermal therapies have been intensively reported to treat osteomyelitis, [1,7] but the limited penetration depth of light (visible or near infrared light) cannot fulfill the treatment request of patients with deep bone marrow infection. Alternatively, exogenous stimuli like ultrasound (US) and microwave have strong penetrating ability. [8] Our group recently reported that sonodynamic [9] and microwave therapies [10] can beThe ORCID identification number(s) for the author(s) of this article can be found under

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

“…Several studies have found that SDT had significant bactericidal activity against bacterial infections, and even methicillin-resistant Staphylococcus aureus ( Yu et al, 2021 ). Meanwhile, as PDT is limited by the inability of light to penetrate through human tissue, SDT that could overcome this limitation, exhibit great potential to address the problem of deep tissue bacterial infection such as osteomyelitis, otitis media, and periprosthetic infection ( Su et al, 2020 ; Feng et al, 2022 ; Su et al, 2022 ).…”

Engineering single-atom catalysts toward biomedical applications

“…312 As a consequence, it is urgent to develop superior single-atom sonocatalysts for the treatment of osteomyelitis. To this end, Feng et al 297 recently developed a bi-functional sonosensitizer, Zn-SACs, for treating osteomyelitis through sonodynamic therapy and the osteoinductive ability of Zn 2+ (Fig. 17e–h).…”

Single-atom nanozymes: From bench to bedside

“…It is estimated 700,000 people a year die of drug-resistant bacteria infections [41][42][43]. In this case, it is important to develop novel materials for treating infections [44,45]. Recently, SACs/SANs have shown great potential in fighting against the infection (Table 1).…”