Ultrasonic multimodality imaging features and the classification value of nonpuerperal mastitis

Li, Chunxiao; Yao, Meicun; Li, Xin; Shao, Shuo; Chen, Jing; Li, Gang; Chen, Jia; Wu, Rong

doi:10.1002/jcu.23205

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Elastography is an imaging technique used to measure tissue hardness. Previous studies have established a connection between greater tissue hardness in infiltrating lesions within breast masses and an elevated risk of poor patient prognosis [25]. NAC can induce changes in both the internal and surrounding tissues of breast cancer lesions due to the effects of the drugs, leading to alterations in tissue hardness [26].…”

Section: Discussionmentioning

confidence: 99%

Predictive value of multimodal ultrasound imaging and BCL-2 expression levels in the outcome of neoadjuvant chemotherapy for breast cancer

2024

EJGO

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A cohort of 60 breast cancer patients undergoing neoadjuvant chemotherapy (NAC) from January 2021 to December 2022 was studied at the First Affiliated Hospital of Xinjiang Medical University. Multimodal ultrasound examinations were conducted before and after NAC. Levels of B-lymphocytoma-2 (BCL-2) and Ki-67 were assessed through immunohistochemistry both before NAC and during radical mastectomy. Based on the Miller-Payne system, the efficacy of NAC in these patients was categorized into pathologic complete remission (pCR) and non-complete remission (npCR). It was found that: Pathological evaluation postoperatively revealed that 26 patients achieved pCR, while 34 experienced npCR following NAC. In both pCR and npCR groups, significant reductions in lesion diameter, peak intensity (PI), area under the curve (AUC) and elasticity score were observed post-NAC, as well as an increase in Strain Ratio (SR). These changes were more pronounced in the pCR group, with statistically significant differences (p < 0.05). Post-NAC, an increase in BCL-2 and a decrease in Ki-67 expression were observed in both groups, although these changes were not statistically significant (p > 0.05). Receiver operating characteristic (ROC) curves and multifactorial regression analysis identified lesion diameter, PI and AUC as significant predictors of NAC efficacy in breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Predictive value of multimodal ultrasound imaging and BCL-2 expression levels in the outcome of neoadjuvant chemotherapy for breast cancer

2024

EJGO

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“…Besides, granulomatous mastitis often showed heterogeneous hyper-enhancement, enlarged enhancement area, and an unclear enhancement margin on CEUS, which made it difficult to distinguish from malignant NMLs. Some findings have shown that granulomatous mastitis lesions were soft and had low elasticity scores [ 35 , 36 , 37 ]. Eight cases of granulomatous mastitis were included in this study, and all had an elasticity score ≤3.…”

Section: Discussionmentioning

confidence: 99%

Non-mass Breast Lesions: Could Multimodal Ultrasound Imaging Be Helpful for Their Diagnosis?

Guo

Wang

et al. 2022

Diagnostics

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Objective: To develop a prediction model for discriminating malignant from benign breast non-mass-like lesions (NMLs) using conventional ultrasound (US), strain elastography (SE) of US elastography and contrast-enhanced ultrasound (CEUS). Methods: A total of 101 NMLs from 100 patients detected by conventional US were enrolled in this retrospective study. The characteristics of NMLs in conventional US, SE and CEUS were compared between malignant and benign NMLs. Histopathological results were used as the reference standard. Binary logistic regression analysis was performed to identify the independent risk factors. A multimodal method to evaluate NMLs based on logistic regression was developed. The diagnostic performance of conventional US, US + SE, US + CEUS and the combination of these modalities was evaluated and compared. Results: Among the 101 lesions, 50 (49.5%) were benign and 51 (50.5%) were malignant. Age ≥45 y, microcalcifications in the lesion, elasticity score >3, earlier enhancement time and hyper-enhancement were independent diagnostic indicators included to establish the multimodal prediction method. The area under the receiver operating characteristic curve (AUC) of US + SE + CEUS was significantly higher than that of US (p < 0.0001) and US + SE (p < 0.0001), but there was no significant difference between the AUC of US + SE + CEUS and the AUC of US + CEUS (p = 0.216). Conclusion: US + SE + CEUS and US + CEUS could significantly improve the diagnostic efficiency and accuracy of conventional US in the diagnosis of NMLs.

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Value of contrast-enhanced ultrasound in differentiating granulomatous mastitis from invasive ductal carcinoma

Xu,

Yuan,

Liu

et al. 2024

British Journal of Radiology

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Objective This study aims to analyze the imaging manifestations of granulomatous mastitis (GM) and invasive ductal carcinoma (IDC) using conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS). The objective is to investigate the clinical value of CEUS in differentiating between GM and IDC. Methods We retrospectively enrolled 39 GM patients and 64 IDC patients between January 2020 and June 2023. All diagnoses were confirmed via core needle biopsy or surgical pathology. The characteristics of both conventional US and CEUS in these patients were analyzed to distinguish GM from IDC. Results Based on CEUS features, GM lesions most commonly presented as hypoechoic areas (43.6%), followed by pseudocysts (28.2%), hypoechoic nodules (15.4%), and honeycomb cysts (12.8%). The diffuse enhancement pattern was an independent characteristic for distinguishing GM from IDC, with the ROC analysis revealing an area under the curve (AUC) value of 0.794. Conclusion US is the preferred initial examination for GM, and both its conventional and CEUS features can enhance diagnostic accuracy and guide clinical treatment. CEUS demonstrates high differential diagnostic value in distinguishing GM from IDC. Advance in Knowledge This study categorizes GM manifestations on CEUS into four types, each corresponding to different pathological stages of GM. We identified that the diffuse enhancement pattern on CEUS is a distinctive characteristic associated with GM, aiding in its differentiation from IDC.

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Ultrasonic multimodality imaging features and the classification value of nonpuerperal mastitis

Cited by 4 publications

References 20 publications

Predictive value of multimodal ultrasound imaging and BCL-2 expression levels in the outcome of neoadjuvant chemotherapy for breast cancer

Predictive value of multimodal ultrasound imaging and BCL-2 expression levels in the outcome of neoadjuvant chemotherapy for breast cancer

Non-mass Breast Lesions: Could Multimodal Ultrasound Imaging Be Helpful for Their Diagnosis?

Value of contrast-enhanced ultrasound in differentiating granulomatous mastitis from invasive ductal carcinoma

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