Ultrasonic nanotherapy of breast cancer using novel ultrasound-responsive alginate-shelled perfluorohexane nanodroplets: In vitro and in vivo evaluation

Baghbani, Fatemeh; Chegeni, Mahdieh; Moztarzadeh, Fathollah; Mohandesi, Jamshid Aghazadeh; Mokhtari‐Dizaji, Manijhe

doi:10.1016/j.msec.2017.02.017

Cited by 42 publications

(22 citation statements)

References 47 publications

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“…In vivo ovarian cancer treatment using nanodroplets combined with ultrasound irradiation resulted in efficient tumor regression. The authors further developed DOX-loaded ultrasound-responsive alginate/PFC nanodroplets (~51.7 nm) via the same nanoemulsion process [ 105 ]. The alginate shell could improve stealth properties from the reticuloendothelial system (RES) and result in higher accumulation of the drug at the tumor site through the EPR effect.…”

Section: Functionalization Strategies Of Alginate-based Platforms mentioning

confidence: 99%

Alginate-Based Platforms for Cancer-Targeted Drug Delivery

Shang

et al. 2020

BioMed Research International

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As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and biodegradable. A significant number of studies have confirmed the potential use of alginate-based platforms as effective vehicles for drug delivery for cancer-targeted treatment. In this review, the focus is on the formation of alginate-based cancer-targeted delivery systems. Specifically, some general chemical and physical properties of alginate and different types of alginate-based delivery systems are discussed, and various kinds of alginate-based carriers are introduced. Finally, recent innovative strategies to functionalize alginate-based vehicles for cancer targeting are described to highlight research towards the optimization of alginate.

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Section: Functionalization Strategies Of Alginate-based Platforms mentioning

confidence: 99%

Alginate-Based Platforms for Cancer-Targeted Drug Delivery

Shang

et al. 2020

BioMed Research International

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“…Various NDs with polymer shells have been fabricated with the development of polymer materials. The most often used polymer materials include natural polymers such as chitosan [7,8] and alginate [9], as well as synthetic block polymer materials such as poly (ethylene glycol)-block-Poly (ε-caprolactone) (PEG-PCL) [10,11]. Due to the stability and stiffness of the shell, polymeric NDs usually have a higher cavitation threshold and longer circulation time than lipid NDs [12].…”

Section: The Shells Of Ndsmentioning

confidence: 99%

“…However, NDs with a PFP core are unstable during storage, and their irreversible droplet-tobubble transition is hard to control [21]. In order to obtain nanodroplets with higher stability, PFH was chosen for the core of NDs because of its higher boiling point (58-60 °C) compared to other common PFCs including PFP [7,9,22]. In the study of Baghbani et al [9], despite the relatively high boiling temperature of PFH, NDs converted into microbubbles under the action of ultrasound.…”

Section: The Cores Of Ndsmentioning

confidence: 99%

“…In order to obtain nanodroplets with higher stability, PFH was chosen for the core of NDs because of its higher boiling point (58-60 °C) compared to other common PFCs including PFP [7,9,22]. In the study of Baghbani et al [9], despite the relatively high boiling temperature of PFH, NDs converted into microbubbles under the action of ultrasound. It was also demonstrated that chitosan/PFH NDs can be detected even at low concentrations, which could serve as highly sensitive theranostic agents for simultaneous tumor imaging and therapy [7].…”

Section: The Cores Of Ndsmentioning

confidence: 99%

“…The ultrasound pressure required to induce the [24,25] Perfluoropentane DDFP/PFP C 5 F 12 29 Lipid [12] PEG-PCL [10] PGA-g-Mpeg [18] Perfluorohexane PFH C 6 F 14 58 Chitosan [7] Alginate [9] Polypyrrole [22] Polydopamine [13] Perfluoro-15-crown-5-ether PFCE C 10 F 20 O 5 146 PEG-PLLA [21] Perfluorooctyl bromide PFOB C 8 BrF 17 142 Egg lecithin, PEG [26] phase transition of the droplets is affected by a large number of factors, which can be divided into three categories: environmental factors, droplet design, and ultrasound parameters. Through encapsulation in a lipid or polymer shell, Kandadai and colleagues showed that the interfacial surface tension of PFP droplets may be modified by the choice of emulsifier to provide more favorable properties for dispersion in aqueous media [39].…”

Section: Acoustic Droplet Vaporization (Adv)mentioning

confidence: 99%

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Advances in Targeted Tumor Diagnosis and Therapy Based on Ultrasound-Responsive Nanodroplets

Li¹,

Liu²,

Duan³

et al. 2020

Advanced Ultrasound in Diagnosis and Therapy

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The ultrasound contrast agents currently used in clinics are microbubbles with a large particle size and short circulation time, and their approved clinical applications are limited to endovascular diagnosis and therapy only. The development of ultrasound-responsive nanodroplets (NDs) provides a new approach for extravascular diagnosis and therapy, especially for molecular imaging and targeted therapy of tumors. The NDs with a nano-scaled particle size and a liquid core can maintain their shape and initial diameter during injection, enhancing their EPR effects and facilitating the accumulation of NDs at the tumor site. When exposed to ultrasound, NDs can vaporize and exhibit contrast enhancement at the sites of interest. In addition, the destruction of microbubbles can provide a driving force to facilitate the release of drugs or genes from the microbubbles into target cells, allowing the NDs to act as drug carriers. The development of ultrasound-responsive NDs has shown rapid progress in recent years, while a variety of NDs with excellent properties have been fabricated for targeted diagnosis and drug delivery. In this article, the development of ultrasound-responsive NDs was reviewed in terms of their structure, phase transition properties, and applications in targeted tumor diagnosis and therapy.

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