Ultrasonic nebulization platforms for pulmonary drug delivery

Yeo, Leslie; Friend, James; McIntosh, Michelle Paula; Meeusen, Elza Nicole Theresia; Morton, David Alexander Vodden

doi:10.1517/17425247.2010.485608

Cited by 115 publications

(70 citation statements)

References 107 publications

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“…Omitting the PCL excipient, showed that nanoparticles of insulin and BSA could be fabricated using SAW atomization of buffered deionized water solutions of these biological proteins at a concentration from 0.5 to 2 mg=m'. They also showed if the SAW atomized drops were prevented from evaporation, as would happen in inhalation, for example (Groneberg et al, 2003;Yeo, Friend et al, 2010), the nebulized drops would be around 3 m in diameter and therefore ideal for drug delivery via the pulmonary system. Because the SAW atomizer is capable of forming nebulized mists of these large molecules without damaging them, it may be a reasonable means to deliver such molecules as a portable device.…”

Section: Atomizationmentioning

confidence: 99%

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

2011

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This article reviews acoustic microfluidics: the use of acoustic fields, principally ultrasonics, for application in microfluidics. Although acoustics is a classical field, its promising, and indeed perplexing, capabilities in powerfully manipulating both fluids and particles within those fluids on the microscale to nanoscale has revived interest in it. The bewildering state of the literature and ample jargon from decades of research is reorganized and presented in the context of models derived from first principles. This hopefully will make the area accessible for researchers with experience in materials science, fluid mechanics, or dynamics. The abundance of interesting phenomena arising from nonlinear interactions in ultrasound that easily appear at these small scales is considered, especially in surface acoustic wave devices that are simple to fabricate with planar lithography techniques common in microfluidics, along with the many applications in microfluidics and nanofluidics that appear through the literature.

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Section: Atomizationmentioning

confidence: 99%

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

2011

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“…53,54 Although better deposition, compared to jet nebulizer, has been reported with newer models, 53 the impression is that the ultrasonic nebulizer technology requires more development in order to achieve wider acceptance. 55 For example, the versatility of ultrasonic nebulizers in clinical practice may be restricted due to heating issues. In contrast to jet nebulizers (in which drug solutions cool during aerosolization), ultrasonic nebulizers tend to heat up solutions as much as 20°C over 6 min.…”

Section: Nebulizersmentioning

confidence: 99%

Adjunct Therapies During Mechanical Ventilation: Airway Clearance Techniques, Therapeutic Aerosols, and GasesDiscussion

Kallet

2013

Respir Care

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Mechanically ventilated patients in respiratory failure often require adjunct therapies to address special needs such as inhaled drug delivery to alleviate airway obstruction, treat pulmonary infection, or stabilize gas exchange, or therapies that enhance pulmonary hygiene. These therapies generally are supportive in nature rather than curative. Currently, most lack high-level evidence supporting their routine use. This overview describes the rationale and examines the evidence supporting adjunctive therapies during mechanical ventilation. Both mechanistic and clinical research suggests that intrapulmonary percussive ventilation may enhance pulmonary secretion mobilization and might reverse atelectasis. However, its impact on outcomes such ICU stay is uncertain. The most crucial issue is whether aerosolized antibiotics should be used to treat ventilatorassociated pneumonia, particularly when caused by multi-drug resistant pathogens. There is encouraging evidence from several studies supporting its use, at least in individual cases of pneumonia non-responsive to systemic antibiotic therapy. Inhaled pulmonary vasodilators provide at least short-term improvement in oxygenation and may be useful in stabilizing pulmonary gas exchange in complex management situations. Small uncontrolled studies suggest aerosolized heparin with N-acetylcysteine might break down pulmonary casts and relieve airway obstruction in patients with severe inhalation injury. Similar low-level evidence suggests that heliox is effective in reducing airway pressure and improving ventilation in various forms of lower airway obstruction. These therapies generally are supportive and may facilitate patient management. However, because they have not been shown to improve patient outcomes, it behooves clinicians to use these therapies parsimoniously and to monitor their effectiveness carefully. Key words: high-frequency percussive ventilation; intrapulmonary percussive ventilation; inhaled nitric oxide; aerosolized prostacyclin; aerosolized heparin; metered-dose inhalers; heliox.

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“…1 Representation of the principles of a typical jet nebulizer [26]. Jet (or pneumatic) nebulizers effectively suck drug-containing liquid into the jet nozzle via high-velocity air flows.…”

Section: Nebulizer Device Characteristicsmentioning

confidence: 99%

“…2 Representation of a vibrating mesh nebulizer [26]. Aerosol droplets are generated by a perforated vibrating mesh which can be customized to the physicochemical properties of a particular drug formulation by altering size, number and distribution of the holes, power input, and frequency to the piezo element [28].…”

Section: Nebulizer Device Characteristicsmentioning

confidence: 99%

Innovation in Surfactant Therapy II: Surfactant Administration by Aerosolization

Pillow

Minocchieri

2012

Neonatology

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Instilled bolus surfactant is the only approved surfactant treatment for neonatal respiratory distress syndrome. However, recent trends towards increased utilization of noninvasive respiratory support for preterm infants with surfactant deficiency have created a demand for a similarly noninvasive means of administering exogenous surfactant. Past approaches to surfactant nebulization met with varying success due to inefficient aerosol devices resulting in low intrapulmonary delivery doses of surfactant with variable clinical effectiveness. The recent development of vibrating membrane nebulizers, coupled with appropriate positioning of the interface device, indicates that efficient delivery of aerosolized surfactant is now a realistic goal in infants. Evidence of clinical effect despite low total administered dose in pilot studies, together with suggestions of enhanced homogeneity of pulmonary distribution indicate that this therapy may be applied in a cost-effective manner, with minimal patient handling and disruption. These studies need to be subjected to appropriately designed randomized controlled trials. Further work is also required to determine the optimum delivery route (mask, intranasal prong, nasopharyngeal or laryngeal), dosing amount and redosing interval.

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Ultrasonic nebulization platforms for pulmonary drug delivery

Cited by 115 publications

References 107 publications

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

Adjunct Therapies During Mechanical Ventilation: Airway Clearance Techniques, Therapeutic Aerosols, and GasesDiscussion

Innovation in Surfactant Therapy II: Surfactant Administration by Aerosolization

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