Ultrasonic relaxation study of aqueous solutions of cyclodextrins

Kato, Shigeo; Nomura, Hiroyasu; Miyahara, Yutaka

doi:10.1021/j100271a021

Cited by 29 publications

(25 citation statements)

References 3 publications

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“…The ultrasonic absorption coefficient divided by the square of the sound frequency, α/f 2 , approached the value of α/f 2 = 26 × 10 -15 s 2 /m. Since β-CD itself exhibited ultrasonic relaxation at concentrations greater than 13 mM, 16 we fixed the concentration of β-CD at 8.7 mM. Although no excess absorption was observed in individual solutions of β-CD and cAMP, the values of α/f 2 were dependent on the frequency when the solution had both β-CD and cAMP.…”

Section: Resultsmentioning

confidence: 99%

Complex Formation of Adenosine 3',5'-Cyclic Monophosphate with β-Cyclodextrin: Kinetics and Mechanism by Ultrasonic Relaxation

Bae¹,

Kim²,

Lee

2010

Bulletin of the Korean Chemical Society

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Adenosine 3',5'-cyclic monophosphate (cAMP) is a second messenger responsible for a multitude of cellular responses. In this study, we utilized β-cyclodextrin (β-CD) as an artificial receptor with a hydrophobic cavity to elucidate the inclusion kinetics of cAMP in a hydrophobic environment using the ultrasonic relaxation method. The results revealed that the interaction of cAMP with β-CD followed a single relaxation curve as a result of host-guest interactions. The inclusion of cAMP into the β-CD cavity was found to be a diffusion-controlled reaction. The dissociation of cAMP from the β-CD cavity was slower than that of adenosine 5'-monophosphate (AMP). The syn and anti glycosyl conformations of adenine nucleotides are considered to play an important role in formation of the inclusion complex. Taken together, our findings indicate that hydrophobic interactions are involved in the inclusion complex formation of cAMP with β-CD and provide insight into the interactions of cAMP with cAMP-binding proteins.

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Section: Resultsmentioning

confidence: 99%

Complex Formation of Adenosine 3',5'-Cyclic Monophosphate with β-Cyclodextrin: Kinetics and Mechanism by Ultrasonic Relaxation

Bae¹,

Kim²,

Lee

2010

Bulletin of the Korean Chemical Society

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“…Ultrasonic relaxation studies of the CyDs in aqueous solution show that R-CyD and γ-CyD (but perhaps not -CyD) undergo conformational changes with relaxation times of 10 -8 to 10 -7 s. 170,346,347 Rauth and Knoche 346 and Kato et al 347 observe two relaxations, accompanied by substantial volume changes. These effects may be the result of conformational or solvational changes.…”

Section: F Molecular Dynamicsmentioning

confidence: 99%

The Stability of Cyclodextrin Complexes in Solution

1997

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“…The relaxation is sensitive to molecular volume changes [156] and, therefore, may convey information on the stability constants of host-guest complexes [157]. Furthermore, the use of a large frequency range allows one to follow processes with relaxation times in the range from 20 ps to 20 µs [158][159][160] and thus the kinetics of CD-surfactant association can be investigated [157].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The formation of host–guest complexes between surfactants and cyclodextrins

Valente

Söderman

2014

Advances in Colloid and Interface Science

184

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Cyclodextrins are able to act as host molecules in supramolecular chemistry with applications ranging from pharmaceutics to detergency. Among guest molecules surfactants play an important role with both fundamental and practical applications. The formation of cyclodextrin/surfactant host-guest compounds leads to an increase in the critical micelle concentration and in the solubility of surfactants. The possibility of changing the balance between several intermolecular forces, and thus allowing the study of, e.g., dehydration and steric hindrance effects upon association, makes surfactants ideal guest molecules for fundamental studies. Therefore, these systems allow for obtaining a deep insight into the host-guest association mechanism. In this paper, we review the influence on the thermodynamic properties of CD-surfactant association by highlighting the effect of different surfactant architectures (single tail, double-tailed, gemini and bolaform), with special emphasis on cationic surfactants. This is complemented with an assessment of the most common analytical techniques used to follow the association process. The applied methods for computation of the association stoichiometry and stability constants are also reviewed and discussed; this is an important point since there are significant discrepancies and scattered data for similar systems in the literature.In general, the surfactant-cyclodextrin association is treated without reference to the kinetics of the process. However, there are several examples where the kinetics of the process can be investigated, in particular those where volumes of the CD cavity and surfactant (either the tail or in special cases the head group) are similar in magnitude.This will also be critically reviewed.

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Ultrasonic relaxation study of aqueous solutions of cyclodextrins

Cited by 29 publications

References 3 publications

Complex Formation of Adenosine 3',5'-Cyclic Monophosphate with β-Cyclodextrin: Kinetics and Mechanism by Ultrasonic Relaxation

Complex Formation of Adenosine 3',5'-Cyclic Monophosphate with β-Cyclodextrin: Kinetics and Mechanism by Ultrasonic Relaxation

The Stability of Cyclodextrin Complexes in Solution

The formation of host–guest complexes between surfactants and cyclodextrins

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