Ultrasonic separation in microfluidic capillaries

Araz, M.K.; Lee, Chung-Hoon; Lal, Amit

doi:10.1109/ultsym.2003.1293095

Cited by 18 publications

(9 citation statements)

References 4 publications

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“…3, 35,[49][50][51][52][53][54] In this paper, measurements performed in two glass capillaries are presented to show, respectively, the transducer-plane streaming and the modal Rayleigh-like streaming in layered acoustofluidic particle manipulation devices. The two glass capillaries (Vitrocom, USA) have inner dimensions of 0.3 × 6 mm 2 and 2 × 6 mm 2 (h × w) and wall thicknesses of 0.3 mm and 0.8 mm, respectively.…”

Section: Methodsmentioning

confidence: 99%

Modal Rayleigh-like streaming in layered acoustofluidic devices

2016

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Classical Rayleigh streaming is well known and can be modelled using Nyborg’s limiting velocity method as driven by fluid velocities adjacent to the walls parallel to the axis of the main acoustic resonance. We have demonstrated previously the existence and the mechanism of four-quadrant transducer plane streaming patterns in thin-layered acoustofluidic devices which are driven by the limiting velocities on the walls perpendicular to the axis of the main acoustic propagation. We have recently found experimentally that there is a third case which resembles Rayleigh streaming but is a more complex pattern related to three-dimensional cavity modes of an enclosure. This streaming has vortex sizes related to the effective wavelength in each cavity axis of the modes which can be much larger than those found in the one-dimensional case with Rayleigh streaming. We will call this here modal Rayleigh-like streaming and show that it can be important in layered acoustofluidic manipulation devices. This paper seeks to establish the conditions under which each of these is dominant and shows how the limiting velocity field for each relates to different parts of the complex acoustic intensity patterns at the driving boundaries.

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Section: Methodsmentioning

confidence: 99%

Modal Rayleigh-like streaming in layered acoustofluidic devices

2016

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“…It is well-known that particles suspended in solution can be enriched at certain regions by forces generated from acoustic standing wave fields (81). Suspended particles exposed to an ultrasonic standing wave field experience acoustic radiation forces which can control the movement of particles towards either the pressure nodes or antinodes depending on the sizes, density and compressibility of the particle (21,82). This mechanism has been used for continuous separation of cells or particles in microfluidic channels.…”

Section: Acoustic Mechanismmentioning

confidence: 99%

“…This mechanism has been used for continuous separation of cells or particles in microfluidic channels. Araz et al (82) constructed an actuator by bonding glass capillaries to laser-cut lead zirconate titanate oxide (PZT) plate for ultrasonic control of microparticles or cells inside microfluidic channels. The high velocity generated by the actuator focused the sample at the node and antinode of the bending waves along the channel.…”

Section: Acoustic Mechanismmentioning

confidence: 99%

Microfluidic chips for cell sorting

Chen¹

2008

Front Biosci

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Micro total analysis systems (microTAS) also referred to as "lab-on-a-chip" is one of the fastest progressing fields in biological and chemical analyses. In recent years, microTAS for single cell analysis has drawn the attention of researchers due to its significant advantages over traditional methods for single cell manipulation, fast cell sorting and integration of multiple functions. As the preliminary step for studying cells on chips, cell sorting using microfluidics have been investigated by researchers intensively. This article reviews the most recent advances on microfluidics-based cell sorting techniques including cell sorting principle, strategy, mechanism and procedure with emphases on the sorting mechanism and procedure. Furthermore, evaluation criteria for successful cell sorter are also discussed and future research directions are given.

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“…(3), are given by A=p plP (4) *u r of = r /r (5) where p*,p0,r ,r0 are the density and compressibility of particle and medium, respectively. In Eq.…”

Section: Fundamental Of Ultrasonic Separationmentioning

confidence: 99%

Design and Fabrication of An Ultrasonic Microdevice for Microparticles Separation

Sun

Zhang

et al. 2007

2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems

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In this paper a new microdevice for on-chip separation of microparticles is presented, in which a micromachined silicon nitride membrane structure is bonded with a glass substrate and then PZT plates are bonded to the silicon and glass substrates to excite the microdevice into vibration. Due to the energy coupling, silicon nitride membranes are excited into vibration as well, generating an ultrasonic standing wave field below the membranes, for which we can use it to separate microparticles within the fluids. In the paper, we start from the radiation force analysis and then design and fabricate the practical microdevice, and use finite element method in ANSYS to analyze its separation performance.

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Ultrasonic separation in microfluidic capillaries

Cited by 18 publications

References 4 publications

Modal Rayleigh-like streaming in layered acoustofluidic devices

Modal Rayleigh-like streaming in layered acoustofluidic devices

Microfluidic chips for cell sorting

Design and Fabrication of An Ultrasonic Microdevice for Microparticles Separation

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