Solid-state ultrasonic spot welding (USW) of AA5182-AA5182 and Alclad AA7075-AA7075 was performed to evaluate the microstructural features at weld interface, joint robustness and the static and fatigue properties. Strong and defect-free joints were attained in both aluminum alloys via USW. High temperatures at the weld interface were rapidly reached especially at high welding energy levels, which facilitated the weldability of joints. The microstructure of the weld interface evaluated via electron backscatter diffraction (EBSD) exhibited a necklace-like characteristic with fine grains, manifesting the attainment of robust bonding. The obtained tensile lap shear failure load increased with increasing welding energy, with a maximum of ~6 kN satisfied the requirement of AWS D17.2 standards. Furthermore, the welded joints of both alloys exhibited a superior fatigue resistance, with the so-called "unweldable" AA7075 having a fatigue life even somewhat longer than that of AA5182, which was associated with the existence of softer AA7072 Alclad layer. The results obtained in this study demonstrated that USW is a promising solid-state welding technique with shorter weld cycles and high energy-efficiency, which can be used for joining thin sheets in the automotive applications.