The ultrasonic velocity and density have been calculated for acetamide in the solution NaCl and KCl at different temperatures (viz. 283, 288,293,298K) for various concentrations from 0.02-0.2mol/kg thermodynamic and sound parameters such as adiabatic compressibility, acoustic impedance, relative association, internal pressure, available volume, specific heat ration, relaxation strength, isothermal compressibility, molecular radius, surface tension, enthalpy, Rao’s constant, Wada’s constant, free length, have been gained from research examination for the (Acetamide +H2O/NaCl/KCl). To investigate exactly the type of molecular interactions that exist with NaCl and KCl with acetamide. Among them, KCl with Acetamide interacts most strongly, at a higher concentration as compared to NaCl and H2O solvent. They give stronger solute-solvent interaction with higher mass fractions at higher temperatures.