Ultrasonic techniques for measuring intracranial pulsations

Wallace, WA; Avant, W. S.; McKinney, William Mark; Thurstone, F. L.

doi:10.1212/wnl.16.4.380

Cited by 14 publications

(4 citation statements)

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“…Our results stress the need to perfect techniques of studying echo pulsations--a facet already considered by Wallace et al (1966). The central question in this context is that of the origin of the echo pulsations.…”

Section: Pjm Van Der Lugt and C E M01insupporting

confidence: 52%

Factors influencing cerebral pulsations in ECHO encephalography

Lugt¹,

Molin²

1968

Acta neurochir

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Section: Pjm Van Der Lugt and C E M01insupporting

confidence: 52%

Factors influencing cerebral pulsations in ECHO encephalography

Lugt¹,

Molin²

1968

Acta neurochir

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“…It is well known that using transcranial ultrasound techniques such as TDU or UCTS factors that affect cerebral pulsations can be extracranial or intracranial [18]. Among the extracranial factors there are peripheral vascular changes, such as low systolic arterial pressure.…”

Section: Discussionmentioning

confidence: 99%

“…After intracranial pulsation measurements were pioneered in the USA [18], UCTS was standardized and developed in France [19][20]. In this study, we rehabilitated this former intracerebral tissue-related ultrasonic technique to measure precise PI in the two temporal lobes because our preliminary clinical data have revealed that patients complaining with EHS most often have cognitive defects such as loss of short term memory, attention, and concentration deficiencies, in addition to frequent auditory and olfactory abnormalities.…”

Section: Ultrasonic Cerebral Tomosphygmographymentioning

confidence: 99%

Beneficial effects of a Fermented Papaya Preparation for the treatment of electrohypersensitivity self-reporting patients: results of a phase I-II clinical trial with special reference to cerebral pulsation measurement and oxidative stress analysis

Irigaray

Garrel²,

Carine³

et al. 2018

FFHD

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Background: Electromagnetic Field Intolerance Syndrome (EMFIS), also termed Idiopathic Environmental Intolerance (IEI) attributed to Electromagnetic Fields (IEI-EMF) by WHO, is a newly identified pathological disorder occurring in electrohypersensitivity (EHS) self-reporting patients. To date, there has been no recognized treatment of this disorder. We have shown that EHS self-reporting patients experience some degree of oxidative stress, inflammation, and autoimmune response. Additionally, Fermented Papaya Preparation (FPP) has some antioxidant, anti-inflammation, and immuno-modulating properties. The objective of this phase I-II clinical trial was thus to test whether FPP treatment is well tolerated, can improve clinical outcomes, and normalize biological abnormalities. Methods: 32 EMFIS-bearing patients were serially included in this trial, among which 26 and 16 of them were evaluable after 3 and 6 months of FPP treatment, respectively. Clinical assessment was conducted during a specific face to face interview by using a validated pre-established questionnaire. Biological assessment consisted of measuring intracerebral tissue pulsometric index (PI) in the temporal lobes with ultrasonic cerebral tomosphygmography (UCTS), in addition to oxidative stress and inflammation with a battery of oxidative stress and inflammation-related peripheral blood tests.Results: Overall clinical improvement was obtained in 50-60% of the cases, among which 20-35% presented major improvement that mainly consisted of the regression of cognitive symptoms such as loss of short term memory, concentration, attention deficiencies, insomnia, and fatigue. This clinical improvement was objectively supported by a statistically significant normal recovery of mean PI in the temporal lobes and by a FPP-related antioxidative effect evidenced by a statistically significant decrease in malondialdehyde levels in the plasma (p<0.0001) and increase in the Glutathione peroxidase activity in red blood cells (p<0.01) in patients experiencing oxidative stress. Moreover, this trial evidenced some degree of FPP-related anti-inflammatory effects by demonstrating a statistically significant decrease in histamine (p=0.049) and HSP27/HSP70 chaperone proteins (p=0.007) in the peripheral blood of patients with initial increased values of these inflammation-related biomarkers.Conclusion: The results suggest a beneficial clinical and biological therapeutic effect of FPP in EHS self-reporting patients. However, the precise underlying mechanism has not yet been elucidated.

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“…In fact, after the identification of ultrasounds and use of echoencephalography in 1956 by L. Leksell [ 9 ], numerous international scientific publications have confirmed the existence of a spontaneous natural cerebral pulsatility that is synchronous with cardiac systoles [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Scientific Backgroundmentioning

confidence: 99%

Technical Assessment of Ultrasonic Cerebral Tomosphygmography and New Scientific Evaluation of Its Clinical Interest for the Diagnosis of Electrohypersensitivity and Multiple Chemical Sensitivity

Greco

2020

Diagnostics

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Ultrasonic cerebral tomosphygmography (UCTS), also known as “encephaloscan”, is an ultrasound-based pulsatile echoencephalography for both functional and anatomical brain imaging investigations. Compared to classical imaging, UCTS makes it possible to locate precisely the spontaneous brain tissue pulsations that occur naturally in temporal lobes. Scientific publications have recently validated the scientific interest of UCTS technique but clinical use and industrial development of this ancient brain imaging technique has been stopped notably in France, not for scientific or technical reasons but due to a lack of financing support. UCTS should be fundamentally distinguished from transcranial Doppler ultrasonography (TDU), which, although it also uses pulsed ultrasounds, aims at studying the velocity of blood flow (hemodynamics) in the cerebral arteries by using Doppler effect, especially in the middle cerebral artery of both hemispheres. Instead, UCTS has the technical advantage of measuring and locating spontaneous brain tissue pulsations in temporal lobes. Recent scientific work has shown the possibility to make an objective diagnosis of electrohypersensitivity (EHS) and multiple chemical sensitivity (MCS) by using UCTS, in conjunction with TDU investigation and the detection of several biomarkers in the peripheral blood and urine of the patients. In this paper, we independently confirm the clinical interest of using UCTS for the diagnosis of EHS and MCS. Moreover, it has been shown that repetitive use of UCTS in EHS and/or MCS patients can contribute to the objective assessment of their therapeutic follow-up. Since classical CT scan and MRI are usually not contributive for the diagnosis and are poorly tolerated by these patients, UCTS should therefore be considered as one of the best imaging technique to be used for the diagnosis of these new disorders and the follow-up of patients.

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Ultrasonic techniques for measuring intracranial pulsations

Cited by 14 publications

References 0 publications

Factors influencing cerebral pulsations in ECHO encephalography

Factors influencing cerebral pulsations in ECHO encephalography

Beneficial effects of a Fermented Papaya Preparation for the treatment of electrohypersensitivity self-reporting patients: results of a phase I-II clinical trial with special reference to cerebral pulsation measurement and oxidative stress analysis

Technical Assessment of Ultrasonic Cerebral Tomosphygmography and New Scientific Evaluation of Its Clinical Interest for the Diagnosis of Electrohypersensitivity and Multiple Chemical Sensitivity

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