Ultrasonic Treatment of Subcutaneous Infiltrations after Injections

Mune, O; Thorseth, Kjeld

doi:10.3109/17453676308999863

Cited by 3 publications

(1 citation statement)

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“…[2] Additional research on sonophoresis during the same time period showed beneficial effects of therapeutic ultrasound after injection of drugs[3, 124, 125] and the treatment of localized disorders with ultrasound treatment alone, such as in the treatment of pain, scars, arthritis, epicondylitis, keloid growth, and bursitis. [126–131] The popularity of delivering therapeutic compounds with ultrasound increased over the following decades, with at least 150 independent reports to-date describing the use of ultrasound frequencies greater than 0.7 MHz in the delivery of permeants transdermally.…”

Section: Scope Of Transdermal Delivery Utilizing Sonophoresismentioning

confidence: 99%

Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends

Polat

Hart

Langer

et al. 2011

Journal of Controlled Release

359

290

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The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (≥ 0.7 MHz) for sonophoresis (HFS) dates back to as early as the 1950s, while low-frequency sonophoresis (LFS, 20 – 100 kHz) has only been investigated significantly during the past two decades. Although HFS and LFS are similar because they both utilize ultrasound to increase the skin penetration of permeants, the mechanisms associated with each physical enhancer are different. Specifically, the location of cavitation and the extent to which each process can increase skin permeability are quite dissimilar. Although the applications of both technologies are different, they each have strengths that could allow them to improve current methods of local, regional, and systemic drug delivery. In this review, we will discuss the mechanisms associated with both HFS and LFS, specifically concentrating on the key mechanistic differences between these two skin treatment methods. Background on the relevant physics associated with ultrasound transmitted through aqueous media will also be discussed, along with implications of these phenomena on sonophoresis. Finally, a thorough review of the literature is included, dating back to the first published reports of sonophoresis, including a discussion of emerging trends in the field.

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Section: Scope Of Transdermal Delivery Utilizing Sonophoresismentioning

confidence: 99%