Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: Effects of benzodiazepines

Cuomo, V.; Cagiano, R.; Salvia, Maria Antonietta De; Maselli, M.A.; Renna, G.; Racagni, Giorgio

doi:10.1016/0024-3205(88)90149-x

Cited by 90 publications

(38 citation statements)

References 22 publications

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“…The dosage of diazepam (0.25-1.0 mg/kg, s.c.) used in the present study was supposed to have an anxiolytic effect, with neither muscle relaxation nor sedation occurring. Our results are in agreement with previous findings [1] showing that the attenuation of USV response elicited by unavoidable aversive stimuli are not due to a sedative or musclerelaxant activity of diazepam (0.5-1.0 mg/kg, i.p. ).…”

Section: Discussionsupporting

confidence: 94%

“…Moreover, several psychotropic drugs containing anxiolytic properties attenuated the USV response in this paradigm, as shown in Table 1. The present experimental procedure detected the anxiolytic-like profile of haloperidol in a weakly attenuating the USV response, though several findings have demonstrated that haloperidol had no attenuating effect on the USV response [1,2]. Sánchez recently presented that haloperidol had a weak inhibitory effect on the USV elicited by foot-shocks in adult rats [15].…”

Section: Discussionmentioning

confidence: 78%

“…3). The anxiolytic effects of many benzodiazepines on USVs have been previously shown in adult rats [1,2,10,16] and in rat pups [3,4,20], though the active doses were close to those that produce muscle relaxation and sedation. The dosage of diazepam (0.25-1.0 mg/kg, s.c.) used in the present study was supposed to have an anxiolytic effect, with neither muscle relaxation nor sedation occurring.…”

Section: Discussionmentioning

confidence: 82%

“…Ultrasonic vocalizations (USV), i.e., ultrasonic distress calls, in the 20-30 kHz range have been elicited in adult rats under stressful and painful situations such as electric shocks applied to the feet [1,14,16] or the tail [18] and acoustic startle [5,6,9,19]. In view of the behavioral contexts in which USV are emitted, they are often interpreted as expressions of "fear" or "anxiety" [1,8].…”

Section: Introductionmentioning

confidence: 99%

“…In view of the behavioral contexts in which USV are emitted, they are often interpreted as expressions of "fear" or "anxiety" [1,8]. Many attempts have been made to develop animal models to test the anxiolytic effects of drugs [2,6,10,16].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats

et al. 2003

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Abstract:Ultrasonic vocalization (USV) responses elicited by air-puff stimuli were compared in regard to both quality and quantity with those elicited by electric foot-shock(s) in adult rats. Frequency pattern, duration, repetition rate and interpulse interval of air-puffelicited USV were comparable to those observed on foot-shock-elicited USV. Diazepam (0.25-1.0 mg/kg, s.c.) and buspirone (0.1-1.0 mg/kg, s.c.) attenuated equally and dosedependently the USV responses elicited by both aversive stimuli. Air-puff-elicited USV was specifically attenuated in a dose-dependent manner by the anxiolytic properties of several psychotropic agents: diazepam (1.0-10.0 mg/kg, p.o.), buspirone (10.0-100.0 mg/kg, p.o.), 8-OH-DPAT (0.01-0.5 mg/kg, s.c.). Haloperidol (0.2-1.0 mg/kg, s.c.) weakly attenuated the USV response. Imipramine (0.2-1.0 mg/kg, s.c.) which has no anxiolytic property had no effect. Consequently, air-puff-elicited USV as well as foot-shock-elicited USV may provide a reliable tool for the study of anxiety.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats

et al. 2003

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Recognition and Assessment of Pain in Small Exotic Mammals

Thompson¹

2013

Pain Management in Veterinary Practice

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Comparison of acute and repeated treatment with the 5‐HT_1A receptor ligands 8‐OH‐DPAT and ipsapirone in animal models of anxiety and depression

Vry¹,

Schreiber²

1993

Drug Development Research

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The present study compared the 5-HT,, receptor ligands 8-OH-DPAT and ipsapirone with diazpepam and imipramine in the shock induced ultrasonic vocalization anxiety test and the forced swimming depression test in the rat. Acutely, 8-OH-DPAT induced anxiolytic and antidepressive effects (ED, , : 0.12 and 1.4 mg/kg, i.p., respectively), whereas ipsapirone induced anxiolytic (ED, , : 0.6 mg/kg) and moderate antidepressive effects (33% at 3-10 mg/kg). Virtually no tolerance developed for the anxiolytic effects after 2 weeks of treatment with 0.03-1 mgikg 8-OH-DPAT or 0.1-10 mg/kg ipsapirone (i.p., b.i.d.1, with 10 mg/kg/day ipsapirone (s.c., mini-pumps), or with 1.5 pg/rat/hr 8-OH-DPAT (local infusion in the dorsal raphe nucleus, mini-pumps). However, some tolerance developed for the antidepressive effects of 8-OH-DPAT (ED, , : 0.6,1.4,2.5 and >3 mg/kg, after 2 weeks of pretreatment with vehicle, 0.3, 1, and 3 mg/kg 8-OH-DPAT, respectively, i.p., b.i.d.). In the case of ipsapirone, the dose-effect curve in the forced swimming test was shifted to the left after 2 weeks of pretreatment with ipsapirone (0.3-10 mg/kg, i.p., b.i.d.). Acutely, diazepam induced an anxiolytic effect (ED, , : 3.6 mg/kg, i.p.1, but failed to induce an antidepressive effect; whereas imipramine induced an antidepressive effect (ED, , : 20.5 mg/kg) and a moderate anxiolytic effect (max. efficacy: 47% at 30 mgikg). Upon repeated administration (2 weeks), diazepam (5 mg/kg) showed tolerance for its anxiolytic effects and weak antidepressive effects emerged, whereas imipramine (20 mg/kg) showed weak sensitization for both effects. It is concluded that (a) with all compounds, tolerance, as well as sensitization can be observed, depending on the behavioral test, the dose and the type of compound; and (b) compared with the other compounds tested, relatively low doses of 5-HT,A drugs offer the most attractive profile of mixed anxiolytic/antidepressive activity. o 1993 Wiley-Liss, Inc

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Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: Effects of benzodiazepines

Cited by 90 publications

References 22 publications

Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats

Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats

Recognition and Assessment of Pain in Small Exotic Mammals

Comparison of acute and repeated treatment with the 5‐HT_1A receptor ligands 8‐OH‐DPAT and ipsapirone in animal models of anxiety and depression

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Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: Effects of benzodiazepines

Cited by 90 publications

References 22 publications

Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats

Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats

Recognition and Assessment of Pain in Small Exotic Mammals

Comparison of acute and repeated treatment with the 5‐HT1A receptor ligands 8‐OH‐DPAT and ipsapirone in animal models of anxiety and depression

Contact Info

Product

Resources

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Comparison of acute and repeated treatment with the 5‐HT_1A receptor ligands 8‐OH‐DPAT and ipsapirone in animal models of anxiety and depression