Ultrasonics Promoted Synthesis of  5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

Trilleras, Jorge; Polo-Cuadrado, Efraín; Quiroga, Jairo; Cobo, Justo; Nogueras, Manuel

doi:10.3390/app3020457

Cited by 11 publications

(7 citation statements)

References 60 publications

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“…Jorge Trilleras et al [66] . synthesize ultrasonics assisted synthesis of 5‐(pyrazol‐4‐yl)‐4, 5‐dihydropyrazoles (50) derivatives.…”

Section: All Green Approaches For Pyrazole Synthesismentioning

confidence: 99%

Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Sapkal¹,

Kamble²

2020

ChemistrySelect

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Pyrazole and its derivatives are one of the interesting heterocyclic compounds among the other because it has tremendous important bio-medical applications such as anticancer, antimalarial, antimicrobial, antifungal, antitubercular and antihelishmanial. Synthesis of pyrazoles by synthetic route requires harsh reaction conditions such as organic solvent, high temperature, require large time that consume more energy which increase final cost of the synthesis of pyrazoles. Therefore researchers be aware about synthesis and give more attention towards to develop a greener as well as economically favorable method for synthesis of pyrazoles such as microwave irradiation, ultra-sonication assisted, reaction at room temperature, solvent and catalyst free and use of universal solvent that is aqueous medium these techniques are environmentally friendly as well as cost effective. Therefore, these review highlights the greener methodologies for the synthesis of pyrazoles, which are good alternative for synthetic methods that sustains green principles.

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“…Jorge Trilleras et al [66] . synthesize ultrasonics assisted synthesis of 5‐(pyrazol‐4‐yl)‐4, 5‐dihydropyrazoles (50) derivatives.…”

Section: All Green Approaches For Pyrazole Synthesismentioning

confidence: 99%

Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Sapkal¹,

Kamble²

2020

ChemistrySelect

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“…Representing the use of alternate energy activation, Nogueras et al have synthesized new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives under ultrasonic irradiation conditions in ethanol or methanol/glacial acetic acid mixture [24]. Hydrazines and several chalcone-like heteroanalogues, accessed from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde, are used and the method provides numerous advantages over current methodologies such as shorter reaction times (2-20 min), simple work-up procedure, and good yields.…”

Section: The Present Issuementioning

confidence: 99%

Greener and Sustainable Chemistry

Varma

2014

Applied Sciences

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In the pursuit towards attaining sustainability, arrays of greener pathways are being carved to address the needs of the diverse chemical universe. The evolving area of green and sustainable chemistry envisions minimum hazard as the performance criterion while designing new chemical processes. Green Chemistry is defined as "the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture, and application of chemical products" [1]. Sustainable processes are being sought to explore alternatives to conventional chemical syntheses and transformations. Among several thrust areas for achieving this target includes: the utility of alternative feedstocks, preferably from renewable materials or waste from other industries; unconventional efficient reaction conditions and eco-friendly reaction media to accomplish the desired chemical transformations with minimized by-products or waste generation, and ideally avoiding the use of conventional volatile organic solvents, wherever possible. Other avenues for achieving this objective are to explore the generation of efficient catalytic processes, particularly magnetically retrievable nano-catalysts [1,2,3,4]. In addition to greener synthesis, the recyclability and reuse aspects for catalytic systems are extremely significant particularly when it boils down to the use of endangered elements and precious catalysts. Several friendlier applications in catalysis have been advanced via magnetically recoverable and recyclable nano-catalysts for oxidation, reduction, and multi-component condensation reactions [1,2,3,4] and this has made a terrific impact on the development of green chemical pathways [1]. The greener preparation of nanoparticles has been exemplified via the use of vitamins B1, B2, C, and tea [5] and wine polyphenols [6], beet juice [7] and other agricultural residues which function both as reducing and capping agents. This avoids the need to deploy toxic reducing agents, such as borohydrides or hydrazines and empowers simple and aqueous green synthetic methods to produce bulk quantities of nano-catalysts without the requirement for large amounts of insoluble templates [8]. [...]

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“…The physical properties of the prepared pyrazolines (3a-e) are summarized in Table III. (Trilleras, et al, 2013) A mixture of hydrazine hydrate (2 mmol), curcumin analogous (1 mmol), and sodium hydroxide (0.1 g, 5 mol) in methanol (20 mL) was irradiated for appropriate time at (25-40°C) in a water bath of an ultrasonic cleaner until the disappearance of curcumin analogs indicated by changing the color from yellow to white and monitoring by green color formation in testing with drops of H 2 SO 4 .…”

Section: (Omp-(substitutedbenzyloxy)phenyl)-3-(omp-(substitutementioning

confidence: 99%

Ultrasound-assisted Synthesis of Some New Curcumin Analogs and Their Corresponding Pyrazoline Derivatives

Hawaiz

Omer

2017

ARO

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Abstract-In this work, a series of new curcumin mono-carbonyl analogs containing benzyloxy moieties and their pyrazoline derivatives were synthesized using a green method (ultrasound assisted technique) along with traditional method. The work also includes a comparison between the two methods together and with the reported results. Remarkable improvements were achieved by dropping down the reaction time from hours to minutes and obtaining higher yields of the products.

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Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

Cited by 11 publications

References 60 publications

Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Greener and Sustainable Chemistry

Ultrasound-assisted Synthesis of Some New Curcumin Analogs and Their Corresponding Pyrazoline Derivatives

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