Ultrasonographic Differentiation of Benign From Malignant Neck Lymphadenopathy in Thyroid Cancer

Kuna, Sanja Kusačić; Bračić, Irena; Tešić, Vanja; Kuna, Krunoslav; Herceg, Gordana Horvatić; Dodig, Damir

doi:10.7863/jum.2006.25.12.1531

Cited by 150 publications

(119 citation statements)

References 26 publications

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“…[8][9][10] Nodal necrosis and cystic changes are very common in SCC metastasis, and their frequency increases with nodal size. 1,3,11,12 Shin et al …”

Section: 4mentioning

confidence: 99%

Metastatic Squamous Cell Carcinoma Presenting as Diffuse and Punctate Cervical Lymph Node Calcifications

Shin

Fischbein

Kaplan

et al. 2009

Journal of Ultrasound in Medicine

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Objective. The purpose of this series was to show the sonographic appearance of calcified cervical lymph nodes and the utility of sonographically guided fine-needle aspiration biopsy (FNAB) in the setting of metastatic squamous cell carcinoma (SCC). Methods. Two cases of confirmed metastatic SCC to cervical lymph nodes were identified. Sonography and sonographically guided FNAB were performed in both cases with positron emission tomography (PET)/computed tomography (CT) correlation. Results. In case 1, sonography identified a diffusely calcified, avascular cervical lymph node. Positron emission tomography/CT suggested granulomatous disease as a cause for hypermetabolism; however, sonographically guided FNAB identified metastatic SCC. In the second case, FNAB initially performed without sonographic guidance did not show malignancy. Subsequent FNAB with sonographic guidance identified an abnormal cervical lymph node with focal calcifications and internal color Doppler flow. Metastatic SCC was diagnosed on histopathologic examination. Subsequent PET/CT confirmed multiple punctate calcifications in a hypermetabolic lymph node. Conclusions. Calcifications in cervical lymph nodes from metastatic SCC are very rare. These 2 cases show the variable sonographic appearances and the utility of sonographically guided FNAB in establishing the correct diagnosis.

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“…[8][9][10] Nodal necrosis and cystic changes are very common in SCC metastasis, and their frequency increases with nodal size. 1,3,11,12 Shin et al …”

Section: 4mentioning

confidence: 99%

Metastatic Squamous Cell Carcinoma Presenting as Diffuse and Punctate Cervical Lymph Node Calcifications

Shin

Fischbein

Kaplan

et al. 2009

Journal of Ultrasound in Medicine

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“…In recent years, preoperative ultrasonography has been reported to be an important in predicting CLNM of PTC (Ito et al, 2005;Kuna et al, 2006;González et al, 2007;Zhan et al, 2012). Improving the prediction of CLNM and understanding the correlation between the sonographic features of PTC and CLNM would have strong clinical significance.…”

Section: Introductionmentioning

confidence: 99%

Shorter Distance Between the Nodule and Capsule has Greater Risk of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

Wang¹,

Cheng²,

Wen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…[2] The diagnosis of malignant lymphadenopathy is crucial for therapeutic planning in patients with suspected malignant neoplasms and for pretreatment staging in patients with primary malignant tumours of the head and neck [3].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Colour Doppler Ultrasound in Diagnosis of Cervical Lymphadenopathy

Naik

Pai

Guruprasad

et al. 2012

J. Maxillofac. Oral Surg.

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Objectives The purpose of the study was to evaluate the efficacy of colour doppler ultrasound (CDUS) in diagnosis of cervical lymphadenopathy. Materials and MethodsThe study group consisted of 30 patients with clinical evidence of cervical lymphadenopathy (19 patients with clinically suspected reactive/benign cervical lymphadenopathy and 11 patients with clinically suspected malignant/metastatic cervical lymphadenopathy). CDUS examinations were carried out for one lymph node (LN) in each patient and fine needle aspiration cytology of the same LN was obtained. To evaluate the efficacy of CDUS, comparison between clinical features, CDUS features and cytological features of enlarged cervical LNs were then done. Results Clinical examination evaluated 54 cervical LNs. CDUS evaluation discovered an additional 55 LNs (54 ? 55 = 109). Accuracy of the CDUS examination was higher than clinical evaluation. Patterns of colour doppler flow signals when correlated with cytological diagnosis showed central flow for benign nodes and peripheral flow for malignant nodes. The mean pulsatility index (PI) was 1.977 ± 0.669 in LNs involved with metastases and 0.839 ± 0.135in LNs affected by benign processes. LNs involved with metastases showed a characteristic high resistive index (RI) and a high pulsatility index than the lymph nodes affected by benign processes. The RI and PI were significantly different between LNs affected by benign versus malignant disease. Conclusion Nodal vascularity of the LNs can be used to differentiate benign from malignant lymphadenopathy. CDUS can be trusted upon as a reliable marker for the diagnosis of cervical lymphadenopathy.

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Ultrasonographic Differentiation of Benign From Malignant Neck Lymphadenopathy in Thyroid Cancer

Abstract: Ultrasonography itself cannot distinguish benign from malignant lesions, but an echographic appearance suggests malignancy and helps in the selection of the node to aspirate with ultrasonographically guided FNAB, which is crucial for a final diagnosis.

Cited by 150 publications

References 26 publications

Metastatic Squamous Cell Carcinoma Presenting as Diffuse and Punctate Cervical Lymph Node Calcifications

Metastatic Squamous Cell Carcinoma Presenting as Diffuse and Punctate Cervical Lymph Node Calcifications

Shorter Distance Between the Nodule and Capsule has Greater Risk of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

Efficacy of Colour Doppler Ultrasound in Diagnosis of Cervical Lymphadenopathy

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