Ultrasonographic Evaluation of the Change in Uterine Fibroids Induced by Treatment with a Gnrh Analog

Chia, Chun-Chieh; Huang, Soon-Cen; Chen, Shen-Shien; Kang, Jye-Yi; Lin, Jing-Chuan; Lin, Yuen-Shan; Huang, Kuo-Feng; Lee, Hung-Jung; Zheng, Ching-Cheng

doi:10.1016/s1028-4559(09)60209-6

Cited by 31 publications

(22 citation statements)

References 6 publications

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“…Therefore, uterine weights in EGs decreased compared to CG. These findings are consistent with the reports of Chia et al (2006), Sun et al (2007), Jiang et al (2010) and Wei et al (2010). The results need to be further verified through experiments and clinical applications.…”

Section: Discussionsupporting

confidence: 93%

“…GnRHa may significantly impact uterine growth and development (Chia et al 2006). It has been reported that the uterine volume reduced following subcutaneous injection of 3.75 mg of GnRHa.…”

Section: Discussionmentioning

confidence: 99%

“…The studies indicated that GnRH agonist (GnRHa) treatment could significantly reduce the uterine growth (Chia et al 2006;Sun et al 2007). The uterine volume was reduced by 36% at 12 weeks and 45% at 24 weeks following subcutaneous injection of 3.75 mg of GnRHa, once every 4 weeks, for 24 weeks (Friedman et al 1991).…”

Section: Introductionmentioning

confidence: 99%

“…However, there was no significant difference between the degrees of uterine volume reduction following administration of 3.75 mg leuprolide acetate (Jasonni et al 2001). The reduction of uteri was not associated with the doses and times of administrating the GnRH agonist (Chia et al 2006). Alarelin, a non-apeptide GnRH agonist, has been administered to regulate the reproductive functions in veterinary practice because of its easy synthesis and lower cost.…”

Section: Introductionmentioning

confidence: 99%

“…The effects were dose-dependent (Wei et al 2012). However, the quantitative effects of GnRHa (especially alarelin acetate) immunity in the uterine development of ewes at different doses and durations still remain unclear (Chia et al 2006). It is indeterminate whether a GnRH agonist influences the expression level of LHR protein in the uterus of ewes (Crawford et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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GnRHa active immunity regulates expression of LHR protein and development of uteri in ewes

Wei¹,

Ouyang²,

Guli³

et al. 2013

Journal of Applied Animal Research

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To investigate the LHR protein expressions in the ovine uteri and LH secretion, and to determine whether the alarelin active immunity affects the uterine development in ewes. Twenty-eight ewes (five to six months) were assigned to four experimental groups. Animals in EG-1, EG-2 and EG-3 were subcutaneously injected with 200, 300 and 400 mg alarelin antigens (day 0 and 14), respectively. Animals in the CG were injected with 2.0 mL solvent (day 0 and 14). Uterine horns were dissected aseptically on day 70. The serum LH concentrations were measured using ELISA. Tissue slices were observed and photographed under optical and electron microscopes. The images were measured using Images software. The results showed that the expressions of LHR protein in EGs increased. The level of LHR protein in EG-3 was higher than that in CG (P B0.05). Serum LH concentrations in EGs were lower than that in CG from day 21 to day 45 (P B0.05). Uterine weights in EG-1, EG-2 and EG-3 reduced by 4.66%, 10.20% and 16.63% (PB0.05), respectively. Uterine wall thickness (UWT) in EG-1, EG-2 and EG-3 reduced by 1.41%, 5.84% and 8.75% (P B0.05), respectively. The endometrial epithelium thickness (EET) in EG-1, EG-2 and EG-3 decreased too (P B0.05). The uterine wall shrank obviously and the glandular cavity reduced. The microvilli shortened. The mitochondria and mitochondrial crista decreased. Summarily, alarelin immunity could promote LHR protein expression in the uteri, and decreased serum LH concentrations, including decreased EET, UWT and uterine weights, could affect the uterine microstructure and ultrastructure, resulting in the inhibition of uterine development dose-dependently.

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Section: Discussionsupporting

confidence: 93%

“…GnRHa may significantly impact uterine growth and development (Chia et al 2006). It has been reported that the uterine volume reduced following subcutaneous injection of 3.75 mg of GnRHa.…”

Section: Discussionmentioning

confidence: 99%