Ultrasonographic features of nephrocalcinosis in preterm neonates.

Schell-Feith, Eveline A.; Holscher, Herma C.; Zonderland, H M; Holthe, Joana E. Kist-van; Conneman, Nikk; Zwieten, Paul H. T. van; Brand, Ronald; Heijden, Albert J. van der

doi:10.1259/bjr.73.875.11144796

Cited by 31 publications

(36 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reproducibility of ultrasound in detecting NC in preterm neonates has a very good intraobserver agreement (kappa 0.84), but a moderate interobserver agreement (kappa 0.46) [12]. NC was located exclusively in the medulla in more than 95% of kidneys [12].…”

Section: Diagnosis Of Nephrocalcinosismentioning

confidence: 97%

“…Ultrasonography is a reliable method for screening and grading of young children with risk of NC, with good intra-and interobserver agreement (kappa coefficient, respectively, 0.80 and 0.76) [19]. Reproducibility of ultrasound in detecting NC in preterm neonates has a very good intraobserver agreement (kappa 0.84), but a moderate interobserver agreement (kappa 0.46) [12]. NC was located exclusively in the medulla in more than 95% of kidneys [12].…”

Section: Diagnosis Of Nephrocalcinosismentioning

confidence: 99%

“…NC is diagnosed in 7-64% of preterm neonates with gestational age <32 weeks or birth weight <1,500 g [7][8][9][10][11][12][13][14][15][16]. The wide range in prevalence of NC is a consequence of different study populations and ultrasound equipment and criteria, in addition to a moderate interobserver variation [12].…”

Section: Prevalence Of Nephrocalcinosismentioning

confidence: 99%

“…The wide range in prevalence of NC is a consequence of different study populations and ultrasound equipment and criteria, in addition to a moderate interobserver variation [12]. Recent studies have noted a slightly lower prevalence of 7-41% than in the original reports [12][13][14][15][16].…”

Section: Prevalence Of Nephrocalcinosismentioning

confidence: 99%

See 3 more Smart Citations

Nephrocalcinosis in preterm neonates

2010

View full text Add to dashboard Cite

The prevalence of nephrocalcinosis (NC) in preterm neonates in recent reports is 7-41%. The wide range in prevalence is a consequence of different study populations and ultrasound equipment and criteria, in addition to a moderate interobserver variation. NC in preterm neonates has a multifactorial aetiology, consisting of low gestational age and birth weight, often in combination with severe respiratory disease, and occurs as a result of an imbalance between stone-promoting and stoneinhibiting factors. A limited number of histological studies suggest that calcium oxalate crystals play an important role in NC in premature neonates. In 85% of children resolution of NC occurs in the first years of life. Prematurity, per se, is associated with high blood pressure, relatively small kidneys, and (distal) tubular dysfunction. In addition, NC in preterm neonates can have long-term sequelae for glomerular and tubular function. Long-term follow-up of blood pressure and renal function of prematurely born children, especially with neonatal NC, is recommended. Prevention of NC with (low) oral doses of citrate has not resulted in a significant decrease in the prevalence of NC; a higher citrate dosage deserves further study. Future research pertaining to prevention of NC in preterm neonates is crucial.

show abstract

Section: Diagnosis Of Nephrocalcinosismentioning

confidence: 97%

Section: Diagnosis Of Nephrocalcinosismentioning

confidence: 99%

Section: Prevalence Of Nephrocalcinosismentioning

confidence: 99%

Section: Prevalence Of Nephrocalcinosismentioning

confidence: 99%

See 2 more Smart Citations

Nephrocalcinosis in preterm neonates

2010

View full text Add to dashboard Cite

show abstract

“…For this purpose, two patient populations that frequently develop nephrocalcinosis-preterm infants and renal transplant patients-were selected (44,127,128). Renal tissue from 52 human fetuses with gestational age of 15 to 40 wk was obtained from the archive of the Antwerp University Hospital, Belgium.…”

Section: Cbmmentioning

confidence: 99%

Crystal Retention in Renal Stone Disease

Verkoelen¹

2006

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

The mechanisms that are involved in renal stone disease are not entirely clear. In this article, the various concepts that have been proposed during the past century are reviewed briefly and integrated into current insights. Much attention is dedicated to hyaluronan (HA), an extremely large glycosaminoglycan that may play a central role in renal stone disease. The precipitation of poorly soluble calcium salts (crystal formation) in the kidney is the inevitable consequence of producing concentrated urine. HA is a major constituent of the extracellular matrix in the renal medullary interstitium and the pericellular matrix of mitogen/stress-activated renal tubular cells. HA is an excellent crystal-binding molecule because of its size, negative ionic charge, and ability to form hydrated gel-like matrices. Crystal binding to HA leads to crystal retention in the renal tubules (nephrocalcinosis) and to the formation of calcified plaques in the renal interstitium (Randall's plaques). It remains to be determined whether one or both forms of renal crystal retention are involved in the development of kidney stones (nephrolithiasis).

show abstract