Ultrasonographic Features of the Major Salivary Glands after Radioactive Iodine Ablation in Patients with Papillary Thyroid Carcinoma

Kim, Do Hun

doi:10.1016/j.ultrasmedbio.2015.06.010

Cited by 21 publications

(38 citation statements)

References 17 publications

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“…According to Brozzi et al, 32 patients who underwent RIT did not complain of any symptoms related to RIT, but among the 43 treated patients, there was swelling in 4 (9%), dry mouth (21%) and xerostomia (6.9%) (13). Roh et al showed xerostomia in 85 (33%) of the 256 evaluated patients, and Kim did not evaluate any symptoms related to RIT, which was a limitation of that study (14,15). In conclusion, the present meta-analysis summarizes all available evidence about the side effects caused by RIT on salivary glands in patients with DTC through echotexture evaluation.…”

Section: ' Discussionmentioning

confidence: 83%

“…According to the medical literature, this side effect occurs due to the high radiosensitivity and high turnover rate of epithelial cells in salivary glands and can result in sialadenitis. To monitor the side effects post radioiodine treatment, US has been used as a tool to infer sialadenitis damage post-RIT due to its capacity to identify a heterogeneous echotexture of the major salivary glands ( 2 , 14 - 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, the sample size of their study was only 43 patients, limiting the data interpretation ( 13 ). Kim performed a study in 202 patients from January 2009 to December 2009 and found echotexture heterogeneity in major salivary glands in 46.53%, with no statistical association ( p =0.325) ( 14 ). Roh et al evaluated 256 patients from January 2011 to December 2011 and reported heterogeneity in major salivary glands in 46.8% of patients, with no statistical association ( p =0.325) ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…As previously described, damage to the salivary glands secondary to RIT is activity dependent, agreeing with the results found in all the studies included in our meta-analysis. Kim evaluated the correlation between the prevalence of post-RIT salivary gland damage and radioiodine activity and found a significant association ( p =0.0001) ( 14 ). Lee et al also found a significant difference in the development of sialadenitis between patients who received high radioiodine activity, such as 3700 MBq and 5550 MBq ( p <0.001) ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Ultrasonography Echotexture as a surrogate for Sialadenitis secondary to 131I Radioiodine Therapy for differentiated Thyroid Cancer: a review and metaanalysis

Lima¹,

López²,

Ozorio³

et al. 2020

Clinics

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To systematically review and analyze the medical literature to assess ultrasonography echotexture changes in thyroid cancer patients for the detection of chronic sialadenitis caused by radioiodine therapy. Methods: Sources were retrieved from PubMed, Scopus, EMBASE and LILACS through November 2018. All studies that assessed ultrasonographic features before 131 I administration and at 12 months after 131 I administration were selected. After data extraction, statistical analysis was performed by using Stata software. Results: From a total of 435 studies, 4 studies involving 665 patients were considered eligible, and echotexture heterogeneity was found with a significant difference. Conclusions: Ultrasound echotexture may detect chronic sialadenitis secondary to salivary radioiodine therapy.

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Section: ' Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ultrasonography Echotexture as a surrogate for Sialadenitis secondary to 131I Radioiodine Therapy for differentiated Thyroid Cancer: a review and metaanalysis

Lima¹,

López²,

Ozorio³

et al. 2020

Clinics

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“…Fat tissue can be hypoechoic or hyperechoic depending on its heterogeneity [23]. PGs with complete fatty changes after radioactive iodine ablation for the treatment of thyroid cancer usually exhibit hypoechogenicity [24]. Tissue echogenicity is related to the acoustic reflection caused by variations in the acoustic impedance [25], and tissue with heterogeneous components may display hyperechogenicity due to the presence of multiple acoustic interfaces and increased acoustic reflections within the tissue.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic echogenicity of normal salivary glands in adults: comparison of submandibular and parotid glands

Choi

Paik

2021

Ultrasonography

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The normal submandibular gland (SMG) and parotid gland (PG) are thought to have similar homogeneous ultrasound (US) hyperechogenicity; however, this has not been extensively investigated. The aim of this study was to determine whether the normal SMG and PG have similar US echogenicity. Methods: We included 969 consecutive adult patients with normal salivary glands. The patients were categorized into three age groups: group 1 (19 to 29 years, n=27), group 2 (30 to 49 years, n=273), and group 3 (≥50 years, n=669). The echogenicities of the SMG and PG were prospectively evaluated by an experienced radiologist. Computed tomography (CT) attenuation in Hounsfield units (HUs) was quantitatively measured for the SMG, PG, and sternocleidomastoid muscle in 140 patients. Results: Relative to the PG, the echogenicity of the SMG was similar in 706 (73.0%) and homogeneously hypoechoic in 263 patients (27.0%). The frequency of SMG hypoechogenicity decreased with increasing age (group 1, 59.3%; group 2, 36.3%; group 3, 22.1%; P<0.001). The CT attenuation levels (in HUs) of the SMG and PG were significantly higher in patients with hypoechoic SMGs than in patients with SMG echogenicity similar to that of the PG (P<0.001). Conclusion: Hypoechogenicity of the SMG was observed in approximately one-third of this sample of adults with normal salivary glands. The SMG may be inadequate as a reference standard for evaluating thyroid nodule echogenicity in patients with diffuse thyroid disease with decreased echogenicity.

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Salivary and lacrimal dysfunction after radioactive iodine for differentiated thyroid cancer: American Head and Neck Society Endocrine Surgery Section and Salivary Gland Section joint multidisciplinary clinical consensus statement of otolaryngology, ophthalmology, nuclear medicine and endocrinology

et al. 2020

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Background: Postoperative radioactive iodine (RAI) administration is widely utilized in patients with differentiated thyroid cancer. While beneficial in select patients, it is critical to recognize the potential negative sequelae of this treatment. The prevention, diagnosis, and management of the salivary and lacrimal complications of RAI exposure are addressed in this consensus statement. Methods: A multidisciplinary panel of experts was convened under the auspices of the American Head and Neck Society Endocrine Surgery and Salivary Gland Sections. Following a comprehensive literature review to assess the current best evidence, this group developed six relevant consensus recommendations. Results: Consensus recommendations on RAI were made in the areas of patient assessment, optimal utilization, complication prevention, and complication management. Conclusion: Salivary and lacrimal complications secondary to RAI exposure are common and need to be weighed when considering its use. The recommendations included in this statement provide direction for approaches to minimize and manage these complications.

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Ultrasonographic Features of the Major Salivary Glands after Radioactive Iodine Ablation in Patients with Papillary Thyroid Carcinoma

Cited by 21 publications

References 17 publications

Ultrasonography Echotexture as a surrogate for Sialadenitis secondary to 131I Radioiodine Therapy for differentiated Thyroid Cancer: a review and metaanalysis

Ultrasonography Echotexture as a surrogate for Sialadenitis secondary to 131I Radioiodine Therapy for differentiated Thyroid Cancer: a review and metaanalysis

Ultrasonographic echogenicity of normal salivary glands in adults: comparison of submandibular and parotid glands

Salivary and lacrimal dysfunction after radioactive iodine for differentiated thyroid cancer: American Head and Neck Society Endocrine Surgery Section and Salivary Gland Section joint multidisciplinary clinical consensus statement of otolaryngology, ophthalmology, nuclear medicine and endocrinology

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