Ultrasonographic Features of Triple-Negative Breast Cancer: a Comparison with Other Breast Cancer Subtypes

Yang, Qi; Liu, Hongyan; Liú, Dan; Song, Yanqiu

doi:10.7314/apjcp.2015.16.8.3229

Cited by 45 publications

(64 citation statements)

References 13 publications

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“…Tumors with a high histological grade and high Ki‐67 expression are expected to have a high mitotic rate and short doubling time . The tumors are prone to be homogeneous with intensive cellularity, leading to less US wave attenuation and enhanced through‐transmission, which result in posterior echo enhancement . Meanwhile, a higher proliferation rate suggests rapid tumor growth and a more active metabolism.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Ultrasound Features and Biological Properties of Invasive Breast Carcinoma Is Modified by Age, Tumor Size, and the Preoperative Axilla Status

Tong

Sun

Zhou

et al. 2019

J of Ultrasound Medicine

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Objectives-To investigate the value of ultrasound (US) feature-based models in predicting the proliferation and invasiveness of invasive breast cancer (IBC) and to compare the performance of models based solely on US features with models that combined US features, patient age, tumor size, and axilla status from US.Methods-With ethical approval, 746 patients with a pathologic diagnosis of IBC were reviewed for preoperative clinical, US, and postoperative pathologic data. The proliferation and invasiveness properties of the IBC included the histologic grade and Ki-67 status and lymphovascular invasion (LVI) and axillary lymph node metastasis (ALNM), respectively. Logistic regression analyses were used to identify independent risk factors for tumor proliferation and invasiveness.Results-Posterior echo enhancement, calcification, a tumor size larger than 2 cm, and suspicion of ALNM from axillary US were independent risk factors for a high histologic grade and high Ki-67 expression of IBC (P < .05). A posterior echo shadow, patient age younger than 45 years, and suspicious findings on axillary US imaging were independent variables for predicting the presence of LVI and ALNM in IBC (P < .05). Calcification was the independent factor for predicting LVI (P = .013). The predictive performance of the combined models was improved compared with the US feature-based models, with a higher accuracy rate and negative predictive value. The area under curve of the combined models was also significantly higher than that of the single models (P < .05).Conclusions-Compared with the US feature-based models, the combined models yielded better predictive performance. This may provide a more robust model to predict the tumor biological properties of IBC before surgery.

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Section: Discussionmentioning

confidence: 99%

The Association Between Ultrasound Features and Biological Properties of Invasive Breast Carcinoma Is Modified by Age, Tumor Size, and the Preoperative Axilla Status

Tong

Sun

Zhou

et al. 2019

J of Ultrasound Medicine

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“…The US appearance depends on prognostic factors such as proliferation rate and hormone receptor status (55). Early-stage, fastgrowing, and more aggressive subtypes of IDC, such as triple-negative IDC and other high-grade IDCs, tend to be more round, have circumscribed or microlobulated margins, and show posterior acoustic enhancement (56)(57)(58)(59)(60) (Fig 15). Some of the more aggressive subtypes of IDC may therefore mimic benign lesions (55,56,58).…”

Section: Invasive Ductal Carcinomamentioning

confidence: 99%

“…lated margins, and show posterior acoustic shadowing (56,57,(59)(60)(61) (Fig 16). IDCs are therefore a heterogeneous group with a variety of US appearances.…”

Section: Invasive Ductal Carcinomamentioning

confidence: 99%

Automated Three-dimensional Breast US for Screening: Technique, Artifacts, and Lesion Characterization

Zelst¹,

Mann²

2018

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Automated breast (AB) ultrasonography (US) scanners have recently been brought to market for breast imaging. AB US devices use mechanically driven wide linear-array transducers that can image whole-breast US volumes in three dimensions. AB US is proposed for screening as a supplemental modality to mammography in women with dense breasts and overcomes important limitations of whole-breast US using handheld devices, such as operator dependence and limited reproducibility. A literature review of supplemental whole-breast US for screening was performed, which showed that both AB US and handheld US allow detection of mammographically negative early-stage invasive breast cancers but also increase the false-positive recall rate. Technicians with limited training can perform AB US; nevertheless, there is a learning curve for acquiring optimal images. Proper acquisition technique may allow avoidance of common artifacts that could impair interpretation of AB US results. Regardless, interpretation of AB US results can be challenging. This article reviews the US appearance of common benign and malignant lesions and presents examples of false-positive and false-negative AB US results. In situ breast cancers are rarely detected with supplemental whole-breast US. The most discriminating feature that separates AB US from handheld US is the retraction phenomenon on coronal reformatted images. The retraction phenomenon is rarely seen with benign findings but accompanies almost all breast cancers. In conclusion, women with dense breasts may benefit from supplemental AB US examinations. Understanding the pitfalls in acquisition technique and lesion interpretation, both of which can lead to false-positive recalls, might reduce the potential harm of performing supplemental AB US. Online supplemental material is available for this article. RSNA, 2018.

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“…Triple negative breast cancer (TNBC) is a subtype of breast cancer where the cancer cells lack the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) 34 . Out of total breast cancer cases 10 – 20% are TNBC cases and various studies showed the expression of specific miR pattern in these cases which can act as biomarker for cancer diagnosis 30 , 35 , 36 .…”

Section: Mirs Controlling Involution and Breast Cancermentioning

confidence: 99%

MicroRNAs in the development and neoplasia of the mammary gland

Jena

2017

F1000Res

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Study on the role of microRNAs (miRs) as regulators of gene expression through posttranscriptional gene silencing is currently gaining much interest,due to their wide involvement in different physiological processes. Understanding mammary gland development, lactation, and neoplasia in relation to miRs is essential. miR expression profiling of the mammary gland from different species in various developmental stages shows their role as critical regulators of development. miRs such as miR-126, miR-150, and miR-145 have been shown to be involved in lipid metabolism during lactation. In addition, lactogenic hormones influence miR expression as evidenced by overexpression of miR-148a in cow mammary epithelial cells, leading to enhanced lactation. Similarly, the miR-29 family modulates lactation-related gene expression by regulating DNA methylation of their promoters. Besides their role in development, lactation and involution, miRs are responsible for breast cancer development. Perturbed estrogen (E2) signaling is one of the major causes of breast cancer. Increased E2 levels cause altered expression of ERα, and ERα-miR cross-talk promotes tumour progression. miRs, such as miR-206, miR-34a, miR-17-5p, and miR-125 a/b are found to be tumour suppressors; whereas miR-21, miR-10B, and miR-155 are oncogenes. Oncogenic miRs like miR-21, miR-221, and miR-210 are overexpressed in triple negative breast cancer cases which can be diagnostic biomarker for this subtype of cancer. This review focuses on the recent findings concerning the role of miRs in developmental stages of the mammary gland (mainly lactation and involution stages) and their involvement in breast cancer progression. Further studies in this area will help us to understand the molecular details of mammary gland biology, as well as miRs that could be therapeutic targets of breast cancer.

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Ultrasonographic Features of Triple-Negative Breast Cancer: a Comparison with Other Breast Cancer Subtypes

Cited by 45 publications

References 13 publications

The Association Between Ultrasound Features and Biological Properties of Invasive Breast Carcinoma Is Modified by Age, Tumor Size, and the Preoperative Axilla Status

The Association Between Ultrasound Features and Biological Properties of Invasive Breast Carcinoma Is Modified by Age, Tumor Size, and the Preoperative Axilla Status

Automated Three-dimensional Breast US for Screening: Technique, Artifacts, and Lesion Characterization

MicroRNAs in the development and neoplasia of the mammary gland

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