Ultrasonographic measurement of amniochorionic membrane in asymptomatic pregnant women is not a useful tool for preterm birth prediction

Başaran, Derman; Özyüncü, Özgür; Kara, Özgür; Şahin, Nihal; Turğal, Mert; Önderoǧlu, L.

doi:10.1111/jog.12121

Cited by 5 publications

(14 citation statements)

References 15 publications

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“…The preterm birth rate in this population was 6.8%. These authors noted that the lower rate of preterm birth in this study might have contributed to the differing results from the Severi and colleagues study [19, 20]. These authors also suggest that magnification artifacts that occur during the still image as well as differing etiologies of preterm birth may contribute to the differences in their results compared to that of Severi.…”

Section: Resultsmentioning

confidence: 63%

“…It examined amniochorionic membrane thickness in prediction of preterm birth among an asymptomatic pregnant patient population [20]. This study examined 190 women and measured the fetal membranes between 18 and 22 weeks and then again between 28 and 32 weeks using transabdominal ultrasound.…”

Section: Resultsmentioning

confidence: 99%

“…This study examined 190 women and measured the fetal membranes between 18 and 22 weeks and then again between 28 and 32 weeks using transabdominal ultrasound. A 5.7 MHz abdominal convex probe was used, employing a method similar to that in the Severi study [19, 20]. This team did not find a statistically significant difference between fetal membrane thicknesses in the second or third trimester compared to those that delivered pre-term.…”

Section: Resultsmentioning

confidence: 99%

“…The second study by Frigo found that in vitro fetal membrane thickness was significantly thinner in PROM patients with evidence of leukocyte infiltration and a thicker intermediary zone [18]. The two in vivo studies used similar ultrasound methodology but found conflicting results [19, 20]. Severi found statistically significant thicker membranes in those that delivered preterm whereas the Basaran study found no statistical difference [19, 20].…”

Section: Resultsmentioning

confidence: 99%

“…The two in vivo studies used similar ultrasound methodology but found conflicting results [19, 20]. Severi found statistically significant thicker membranes in those that delivered preterm whereas the Basaran study found no statistical difference [19, 20]. The characteristics of fetal membranes after delivery may reflect changes to the fetal membranes that occur during or after delivery.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

Nunes

Cross

Speich

et al. 2016

BMC Pregnancy Childbirth

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BackgroundPreterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients. Our goal was to identify how imaging methods can be utilized for examining the risks for PPROM in asymptomatic patients.MethodsThis paper is a systematic review of the literature on fetal membrane thickness and its use for the prediction of PPROM. Four key studies are identified and reviewed; two in vitro studies and two in vivo ultrasound studies each using differing methodologies. Additionally reviewed is a study using Optical Coherence Tomography, an emerging technique using near-infrared technology to produce high-resolution images.ResultsThere is currently insufficient data to determine the association between fetal membrane thickness and PPROM by ultrasound.ConclusionsFetal membrane thickness could have relevant clinical ramifications for the prediction of PPROM. Suggested improvements in study methodology and design will lead to progress in this area of research, as well as the use of newer technologies. Larger sample sizes, histological comparison, uniform methodologies for data collection, longitudinal study design and expanding data analysis beyond fetal membrane thickness to other properties would expand our knowledge in this field. In addition, transvaginal ultrasound should be utilized to improve resolution, as well as emerging methodologies such as MRI fusion imaging using ultrasound and Shear Wave Elastography.

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Section: Resultsmentioning

confidence: 63%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

Nunes

Cross

Speich

et al. 2016

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

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The role of noninvasive diagnostic imaging in monitoring pregnancy and detecting patients at risk for preterm birth: a review of quantitative approaches

Helmi

Siddiqui

Yan

et al. 2020

The Journal of Maternal-Fetal & Neonatal Medicine

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Magnetic resonance imaging of the supra-cervical fetal membrane detects an increased risk of prelabor rupture of membranes

Zhao²,

Wang³

et al. 2022

Front. Endocrinol.

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ObjectiveIn 10% of term deliveries and 40% of preterm deliveries, the fetal membrane (FM) ruptures before labor. However, the ability to predict these cases of premature rupture of membranes (PROM) and preterm premature rupture of membranes (PPROM) is very limited. In this paper, our objective was to determine whether a prediction method based on T2 weighted magnetic resonance imaging (MRI) of the supra-cervical FM could predict PROM and PPROM.MethodsThis prospective cohort study enrolled 77 women between the 28th and 37th weeks of gestation. Two indicators of fetal membrane defects, including prolapsed depth >5 mm and signal abnormalities, are investigated for our prediction. Fisher’s exact test was used to determine whether prolapsed depth >5 mm and/or signal abnormalities were associated with PROM and PPROM. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated for prolapsed depth >5 mm, signal abnormalities, and the combination of prolapsed depth >5 mm and signal abnormalities.ResultAmong 12 women with PROM (5 preterm and 7 term, prior to labor onset), 9 had membrane prolapse >5 mm and 5 had FM signal abnormalities. Among 65 women with rupture of membranes at term, 2 had membrane prolapse >5 mm and 1 had signal abnormalities. By Fisher’s exact test both indicators, membrane prolapse >5 mm and signal abnormalities, were associated with PROM (P<0.001, P<0.001) and PPROM (P=0.001, P<0.001). Additionally, membrane prolapse >5 mm, signal abnormalities, and the combination of the two indicators all demonstrated high specificity for predicting PROM (96.9%, 98.5%, and 100%, respectively) and PPROM (90.3%, 97.2%, and 100%, respectively).ConclusionMRI can distinguish the supra-cervical fetal membrane in vivo and may be able to identify women at high risk of PPROM.

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Ultrasonographic measurement of amniochorionic membrane in asymptomatic pregnant women is not a useful tool for preterm birth prediction

Abstract: In this study, ultrasonographic measurement of fetal membranes was not found to be a useful marker for prediction of preterm birth. The findings of our study may help in understanding ultrasonographic changes in fetal membranes in normal pregnancies.

Cited by 5 publications

References 15 publications

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

The role of noninvasive diagnostic imaging in monitoring pregnancy and detecting patients at risk for preterm birth: a review of quantitative approaches

Magnetic resonance imaging of the supra-cervical fetal membrane detects an increased risk of prelabor rupture of membranes

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