“…Seventeen of the remaining 29 studies met our inclusion criteria. Fourteen of these 17 studies [2, 17-21, 23, 26, 34, 43, 44, 46, 50, 52] had usable data and were included; the three other studies [30,31,49] did not have usable data and were excluded. The remaining 12 studies did not indicate whether all the patients underwent any treatment before being enrolled in the studies, therefore we sent requests for supplemental data from the authors of the studies.…”