Ultrasonographic tissue quantification of the breast using acoustic radiation force impulse technology: phantom study and clinical application

Tozaki, Mitsuhiro; Saito, Masahiro; Joo, Chanwoong; Miki, Yoshio; Isobe, Sachiko; Ogawa, Yukari; Homma, Kanako; Fukuma, Eisuke

doi:10.1007/s11604-011-0591-9

Cited by 42 publications

(33 citation statements)

References 12 publications

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“…The considerable variability of stiffness value measurements of 80 kPa targets was previously reported and proved to be independent of operators' experience levels [20,30,31].…”

Section: Discussionmentioning

confidence: 52%

Intra- and inter-observer variation and accuracy using different shear wave elastography methods to assess circumscribed objects – a phantom study.

Seliger

Chaoui

Kunze³

et al. 2017

Med Ultrason

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Aims: The elastic properties of circumscribed tissues (e.g., tendons, lymph nodes, prostates, brain tumors) are of considerable clinical interest. The purpose of this study was thus to compare the Intra-/Inter-observer variation and accuracy in vitro of point shear wave elastography (pSWE) with that of 2D-SWE and to assess 2D-SWE’s precision with variable ROI (vROI) incircumscribed objects.Material and methods: Round targets (Elasticity QA Phantom Model 049) were examined for varying degrees of stiffness (8, 14, 45, and 80 kPa) and diameters (20/10 mm). Three ultrasound systems and four probes were applied (pSWE: Acuson/S3000 9L4/4C1 and Epiq7 C51, 2D-SWE: Aplio/500 PVT375BT). Three different ROIs were used, namely fixed ROI (fROI) and variable ROI: rectangular-best-fitted ROI, and round-best-fitted ROI. Each measurement was performed twice by four observers.Results: A total of 3,604 measurements were conducted. The intra-observer variation of 2D-SWE measurements indicated better agreement (Intraclass Correlation Coefficient (ICC) = 0.971; 95% CI=[0.945; 0.985]), than for the pSWE measurements (ICC = 0.872; 95% CI=[0.794; 0.92]). With both methods, the shear wave elastography applied showed low inter-observer variation: ICC = 0.980; 95% CI=[0.970; 0.987]. However, a significant difference was observed between fROI (pSWE) and vROI (2D-SWE) on circumscribed objects in terms of accuracy. The lowest degree of observationerror was detected in situations where the ROI was not “best fitted”, but placed within the target of 3mm from the border (target diameter: 20mm; mean relative error = 0.15).Conclusions: When estimating the elastic properties of circumscribed tissues, the different measurement techniques performed by commercial shear wave elastography systems reveal a strong susceptibility for observational errors, depending upon the fixed vs. variable ROI of the pSWE vs. 2D-SWE technique.

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“…The considerable variability of stiffness value measurements of 80 kPa targets was previously reported and proved to be independent of operators' experience levels [20,30,31].…”

Section: Discussionmentioning

confidence: 52%

Intra- and inter-observer variation and accuracy using different shear wave elastography methods to assess circumscribed objects – a phantom study.

Seliger

Chaoui

Kunze³

et al. 2017

Med Ultrason

View full text Add to dashboard Cite

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“…There are various interpretations of ''x.xx.'' The predominant view is that it indicates high SWVs exceeding 7-8 m/s of the upper limit of the VTQ system (Bojunga et al 2012;Gu et al 2012;Tozaki et al 2011). Some authors substituted a numerical value of 8.4 m/s for ''x.xx,'' but there was no firm basis for this substitution Xu et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Correlation between Quantitative Shear Wave Elastography and Pathologic Structures of Thyroid Lesions

Fukuhara

Matsuda

Endo

et al. 2015

Ultrasound in Medicine & Biology

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“…ARFI-measurements in a phantom have been studied [34], [35], but none has reported on diagnostic performance of either SWE or ARFI in a phantom.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Visual Scoring and Semi-Quantification of Ultrasound Strain Elastography – A Phantom Study

et al. 2014

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PurposeThe aim of this study was to evaluate the performance of strain elastography in an elasticity phantom and to assess which factors influenced visual scoring, strain histograms and strain ratios. Furthermore this study aimed to evaluate the effect of observer experience on visual scorings.Materials and MethodsTwo operators examined 20 targets of various stiffness and size (16.7 to 2.5 mm) in an elasticity phantom at a depth of 3.5 cm with a 5–18 MHz transducer. Two pre-settings were used yielding 80 scans. Eight evaluators, four experienced, four inexperienced, performed visual scorings. Cut-offs for semi-quantitative methods were established for prediction of target stiffness. Data was pooled in two categories allowing calculations of sensitivity and specificity. Statistical tests chi-square test and linear regression as relevant.ResultsStrain ratios and strain histograms were superior to visual scorings of both experienced and inexperienced observers (p = 0.025, strain histograms vs. experienced observers, p<0.001, strain histograms vs. inexperienced observers, p = 0.044 strain ratios vs. experienced observers and p = 0.002 strain ratios vs. inexperienced observers). No significant difference in predicting target stiffness between strain ratios and strain histograms (p = 0.83) nor between experienced and inexperienced observers (p = 0.054) was shown when using four categories. When pooling data in two groups (80 kPa/45 kPa vs. 14/8 kPa) the difference between the observers became significant (p<0.001). Target size had a significant influence on strain ratios measurements (p = 0.017) and on visual scorings (p<0.001) but not on the strain histograms(p = 0.358). Observer experience had significant effect on visual scorings(p = 0.003).ConclusionStrain ratios and strain histograms are superior to visual scoring in assessing target stiffness in a phantom. Target size had a significant impact on strain ratios and visual scoring, but not on strain histograms. Experience influenced visual scorings but the difference between experienced and inexperienced observers was only significant when looking at two classes of target stiffness.

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Ultrasonographic tissue quantification of the breast using acoustic radiation force impulse technology: phantom study and clinical application

Abstract: ARFI tissue quantification is a potentially promising ultrasonographic technique for diagnosing breast lesions.

Cited by 42 publications

References 12 publications

Intra- and inter-observer variation and accuracy using different shear wave elastography methods to assess circumscribed objects – a phantom study.

Intra- and inter-observer variation and accuracy using different shear wave elastography methods to assess circumscribed objects – a phantom study.

Correlation between Quantitative Shear Wave Elastography and Pathologic Structures of Thyroid Lesions

Accuracy of Visual Scoring and Semi-Quantification of Ultrasound Strain Elastography – A Phantom Study

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