Ultrasonography and magnetic resonance imaging in early rheumatoid arthritis: Recent advances

Østergaard, Mikkel; Døhn, Uffe Møller; Ejbjerg, Bo; McQueen, Fiona

doi:10.1007/s11926-006-0069-4

Cited by 15 publications

(8 citation statements)

References 80 publications

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“…Several comparative validation studies of MRI and US in adult rheumatology have been published 21,22,23,24 ; however, to the best of our knowledge, the 2 imaging modalities have …”

Section: Discussionmentioning

confidence: 99%

Cartilage Thickness of the Knee Joint in Juvenile Idiopathic Arthritis: Comparative Assessment by Ultrasonography and Magnetic Resonance Imaging

Pradsgaard

Fiirgaard²,

Spannow³

et al. 2014

J Rheumatol

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“…Several comparative validation studies of MRI and US in adult rheumatology have been published 21,22,23,24 ; however, to the best of our knowledge, the 2 imaging modalities have …”

Section: Discussionmentioning

confidence: 99%

Cartilage Thickness of the Knee Joint in Juvenile Idiopathic Arthritis: Comparative Assessment by Ultrasonography and Magnetic Resonance Imaging

Pradsgaard

Fiirgaard²,

Spannow³

et al. 2014

J Rheumatol

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“…This scheme is frequently supported by imaging techniques, such as radiography, ultrasound, and magnetic resonance imaging (MRI) [10, 11]. The latter facilitates an accurate diagnosis of early RA [12, 13], because it can be applied to confirm the presence of subclinical synovitis [14], to discover RA in clinical remission when there is no sign of swelling or tender joints [15] and to detect bone erosion with a higher sensitivity than plain radiography [16]. Furthermore, although it is not specific for RA, positron emission tomography (PET) with [ 18 F]2-fluoro-2-deoxy- d -glucose (FGD) can reveal arthritic lesions, because the advanced inflammatory processes are generally associated with an elevated energy conversion and, consequently, a higher glucose consumption.…”

Section: Introductionmentioning

confidence: 99%

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

et al. 2019

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Background Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ life quality. There is no causal treatment. Symptomatic therapies should start as early as possible to take maximal effect. Hence, diagnostic procedures capable of detecting affected joints before the onset of clinical symptoms are highly desirable. We explored the value of PET imaging of integrin subtypes αvβ3 and α5β1 for early detection of RA foci in collagen-induced arthritis (CIA) mouse models. Results Development of RA in CIA mice was monitored by paw scoring, and αvβ3- and α5β1-integrin expression was quantified by μPET using 68Ga-Avebetrin and 68Ga-Aquibeprin. For consecutive sections of selected decalcified joints (knee, ankle), arthritic degeneration and integrin expression were assessed by MOVAT staining and β3/α5 immunohistochemistry (IHC), respectively. β3- and α5-IHC revealed elevated levels of both αvβ3- and α5β1-integrin in arthritic joints. Unlike αvβ3, α5β1 is strongly expressed in the proliferating synovial lining layer, which suggests that its presence is directly related to RA development. For mice with advanced RA (6 weeks after CIA), PET signals for α5β1-integrin were substantially stronger (> 300% of baseline) than that of αvβ3-integrin (< 200%). A longitudinal PET follow-up revealed that the manifestation of clinical symptoms of RA is preceded by upregulation of α5β1- but not of αvβ3-integrin. Conclusion α5β1-integrin PET could add a new functional imaging aspect to the portfolio of RA diagnostics because it appears to be a sensitive biomarker for early RA development. We suggest α5β1-integrin PET as a valuable tool to achieve a higher precision for early diagnosis of RA, including initial staging, monitoring of the disease course, and drug treatment, and for planning of radiosynoviorthesis (RSO).

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“…25 Although plain radiographs remain essential for the initial assessment of patients with RA, several studies have suggested the use of ultrasonography and MRI as the imaging exams of choice for assessing early RA. 26 Enhanced MRI, in particular, is extremely sensitive, allowing the detection of areas de intraosseous infl ammation before overt erosions develop. Technical refi ning of those methods is being studied and shows promising results.…”

Section: Discussionmentioning

confidence: 99%

Diagnóstico por imagem da artrite reumatoide inicial

Mota¹,

Laurindo²,

Neto³

et al. 2012

Rev. Bras. Reumatol.

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Early diagnosis of rheumatoid arthritis is essential for its proper management. Currently, the initial phase of rheumatoid arthritis is known to provide a window of therapeutic opportunity. Although the diagnosis is primarily clinical, the development and improvement of laboratory and imaging methods have contributed to earlier diagnosis and determination of procedures in early rheumatoid arthritis. In this article, the authors review the role of the major imaging methods used for assessing early rheumatoid arthritis, especially conventional radiography, ultrasonography, and magnetic resonance imaging.

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Ultrasonography and magnetic resonance imaging in early rheumatoid arthritis: Recent advances

Cited by 15 publications

References 80 publications

Cartilage Thickness of the Knee Joint in Juvenile Idiopathic Arthritis: Comparative Assessment by Ultrasonography and Magnetic Resonance Imaging

Cartilage Thickness of the Knee Joint in Juvenile Idiopathic Arthritis: Comparative Assessment by Ultrasonography and Magnetic Resonance Imaging

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

Diagnóstico por imagem da artrite reumatoide inicial

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