Ultrasound-activated Au/ZnO-based Trojan nanogenerators for combined targeted electro-stimulation and enhanced catalytic therapy of tumor

Ma, Kongshuo; Qi, Guohua; Wang, Bo; Yu, Ting; Zhang, Ying; Li, Haijuan; Kitte, Shimeles Addisu; Jin, Yongdong

doi:10.1016/j.nanoen.2021.106208

Cited by 47 publications

(42 citation statements)

References 59 publications

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“…Given the abundant spin singleelectrons and paramagnetic ability of Co 3+ (4d 6 ), CoP possesses greater potential as MRI contrast than common CoS x and CoSe x . 36,37 From Figure 6A, T 2 -weighted MRI signals darken with the increase of CPC10@PEG concentrations.…”

Section: Mri and Ct Imagingmentioning

confidence: 99%

“…), inorganic nanomaterials (TiO 2 , ZnO, Fe 3 O 4 etc. ), and hybrids have been adopted as sonosensitizers. , Due to the hydrophobicity, organic sensitizers always suffer from aggregation in physiological environments, affecting SDT and pharmacokinetic properties that are associated with the complex preparation and extraction process to further limit their applications. Inorganic nanosonosensitizers possess various compositions, adjustable morphology and structure, superior chemical stability, and low phototoxicity, revealing the greater potential on SDT. − …”

Section: Introductionmentioning

confidence: 99%

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Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Wang

Song

Choi³

et al. 2023

ACS Appl. Mater. Interfaces

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Sonodynamic therapy (SDT) can be described as ultrasonic (US) catalysis. Adequate charge separation is considered as effective means to promote reactive oxygen species (ROS). Here, hollow CoP@N–carbon@PEG (CPCs@PEG) nanospheres (∼60 nm) are prepared as sonosensitizers, showing greater ROS generation than pure CoP@PEG under US irradiation. Both 1O2 and ·O2 – are activation species that are determined by O2 and electrons. The great SDT performance of CPCs@PEG is ascribed to the heterostructure which promotes the separation and transfer for US-generated electrons and holes. In addition, holes can be further captured by endogenous glucose that is in favor of electron aggregation and ROS generation. Moreover, the consumption of glucose would decrease intracellular ATP for starvation therapy. Given the higher oxidation ability of Co3+, CPCs@PEG nanospheres possess catalase (CAT) activity to convert H2O2 into O2 for assisting ROS generation. Moreover, they also can oxidize glutathione (GSH) as a mimic GSH oxidase to break intratumor redox balance, facilitating oxidative stress. More importantly, the nanocomposites reveal good degradation ability dominated by the oxidation from insoluble phosphide into soluble phosphate, accelerating elimination via urine and feces within 14 days. CPCs@PEG nanospheres integrate the above effects not only to reveal great tumor inhibition ability but also to excite immune activation for anticancer.

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Section: Mri and Ct Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Wang

Song

Choi³

et al. 2023

ACS Appl. Mater. Interfaces

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“…CuS and PDA were not detected by XRD, which should be due to their low amount and amorphous state, respectively. [38][39][40][41][42] CT and PCT were further analyzed by X-ray photoelectron spectroscopy (XPS) to confirm the chemical states of elements in the near-surface regions, as shown in Figure 2 and Figure S4 in the Supporting Information. CT contains Ti, O, Cu, S, and C, in which C is associated with contamination and the other elements are contributed by TiO 2 /CuS (Figure 2a).…”

Section: Microstructure Of the Materialsmentioning

confidence: 99%

Photo‐Responded Antibacterial Therapy of Reinfection in Percutaneous Implants by Nanostructured Bio‐Heterojunction

Ding

Zhang

Han

et al. 2022

Small

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Percutaneous implants may experience infection for several times during their servicing periods. They need antibacterial activity and durability to reduce recurrent infection and cytocompatibility to reconstruct biosealing. A novel photoresponse bio‐heterojunction (PCT) is developed herein. It consists of TiO2 nanotubes loaded with CuS nanoparticles and wrapped with polydopamine (PDA) layer. In PCT, a built‐in electric field directing from TiO2 to CuS and then to PDA is formed, and with near‐infrared (NIR) irradiation, it drives photoexcited electrons to transfer in opposite direction, resulting in the separation of electron–hole pairs and formation of reactive oxygen species (ROS). Simultaneously, PCT shows photothermal effect due to nonradiative relaxation of photoexcited electrons and thermal vibration of lattices. The synergic effect of photogenerated ROS and hyperthermia increases bacterial membrane permeability and leakage of cellular components, endowing PCT with outstanding antibacterial performance. More importantly, PCT has good antibacterial durability and cytocompatibility due to the inhibited leaching of CuS by PDA layer. In reinfected models, with NIR irradiation, PCT sterilizes bacteria, reduces inflammatory response and enhances re‐integration of soft tissue efficiently. This work provides an outstanding bio‐heterojunction for percutaneous implants in treating reinfection by NIR irradiation and rebuilding biosealing.

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“…Exogenous stimuli including near-infrared light [5] , ultrasound [6] , magnetic field [7] , microwave [8] , and electric field [9] have been utilized to promote the redox reaction for ROS production. External electric field, as a stimulus that regulates electron motion, plays an important role in reshaping the internal electrostatic field of enzymes to control catalytic reactions in terms of reactivity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

Self‐driven Electrical Stimulation Promotes Cancer Catalytic Therapy Based on Fully Conjugated Covalent Organic Framework Nanocages

Yao

Zheng

Wang

et al. 2022

Adv Funct Materials

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Engineered nanozymes have been developed to catalyze the production of reactive oxygen species (ROS) for cancer therapy, but currently, the ROS generation efficiency is still far from optimistic. In this study, a human self‐driven electrical stimulation enhanced catalytic system based on wearable triboelectric nanogenerator (TENG) and fully π‐conjugated covalent organic framework nanocages (hCOF) for improving cancer therapy is created. The fully π‐conjugated hCOF nanocage with high electron mobility under the self‐generated electric field can not only rearrange the local electric field for optimizing energy utilization, but also facilitates the access of electrolytes to optimize the utilization of the electric field. With the self‐powered wearable TENG, the peroxidase‐like activity of hCOF increased by 2.44‐fold and has electricity‐responsive doxorubicin delivery capacity for enhancing the therapeutic outcomes. The high‐efficient self‐driven electrical stimulation enhanced nanocatalytic system provides a new optimized model for the catalytic energy supply of nanozymes.

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Ultrasound-activated Au/ZnO-based Trojan nanogenerators for combined targeted electro-stimulation and enhanced catalytic therapy of tumor

Cited by 47 publications

References 59 publications

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Photo‐Responded Antibacterial Therapy of Reinfection in Percutaneous Implants by Nanostructured Bio‐Heterojunction

Self‐driven Electrical Stimulation Promotes Cancer Catalytic Therapy Based on Fully Conjugated Covalent Organic Framework Nanocages

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