Ultrasound‐Activated Piezoelectric MoS₂ Enhances Sonodynamic for Bacterial Killing

Abstract

Bacterial infections are a serious public health issue that threatens the lives of patients because of their ability to induce other lethal complications without prompt treatment. Conventional antibiotic therapy can cause bacterial resistance and other adverse effects. It is highly desirable to develop effective and antibiotic‐independent therapeutic strategies to treat various kinds of bacterial infections. Herein, sonodynamic‐enhanced piezoelectric materials MoS2 and Cu2Oheterostructure that responds to exogenous ultrasound (US) and generates reactive oxygen for Staphylococcus aureus elimination are developed. It is shown in the results that the polariton charge induced by piezoelectric MoS2 nanosheets under US irradiation can accelerate the transfer of electric in Cu2O. Furthermore, US irradiation induces valence conversion from Cu(I) to Cu(II), which can accelerate glutathione oxidation significantly and destroy the bacterial antioxidant defense system. Hence, the as‐prepared piezoelectric‐enhanced sonosensitizer possesses a highly effective antibacterial efficacy of 99.85% against S. aureus under US irradiation for 20 min, with good biocompatibility. Herein, effective ultrasonic piezocatalytic therapy is offered through constructing heterogeneous interfaces with ultrasonic piezoelectric response.

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

“…(e) Schematic illustration of the construction process of MoS 2 @Cu 2 O nanosheets. Reprinted with permission from ref . Copyright 2023 John Wiley and Sons.…”

“…This augmented performance is attributed to electronic structural changes and defect generation induced by phase transformation. Expanding the scope of two-dimensional sonodynamic micro-/nanomaterials, Liu et al developed a piezoelectric nanomaterial using a MoS 2 and Cu 2 O heterostructure responsive to external ultrasound (Figure e) . This structure effectively generates ROS for combatting Staphylococcus aureus.…”

“…Expanding the scope of two-dimensional sonodynamic micro-/nanomaterials, Liu et al developed a piezoelectric nanomaterial using a MoS 2 and Cu 2 O heterostructure responsive to external ultrasound (Figure 16e). 578 This structure effectively generates ROS for combatting Staphylococcus aureus. The study demonstrated that polariton charge caused by piezoelectric MoS 2 nanosheets under exposure to ultrasound accelerates electron transfer in Cu 2 O. Additionally, ultrasound-induced valence conversion from Cu(I) to Cu(II) significantly enhances GSH oxidation, effectively disrupting the antioxidant defense system in bacterial.…”