Ultrasound activation of TiO2 in melanoma tumors

Harada, Yoshimi; Ogawa, Koichi; Irie, Yutaka; Endo, Hitomi; Feril, Loreto B.; Uemura, Takashi; Tachibana, Katsuro

doi:10.1016/j.jconrel.2010.10.012

Cited by 158 publications

(123 citation statements)

References 29 publications

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“…Again, as inorganic nanoparticles often interact strongly with light, they can be used as therapeutic agents and diagnostic techniques for SDT. Indeed, research in this fi eld has been carried out on the use of nanoparticle titanium dioxide (TiO 2 ) [41] . It is well known that, upon exposure to ultraviolet (UV) light, TiO 2 particles can produce electrons, which lead to the formation of ROS, such as hydrogen peroxide, hydroxyl radicals, and superoxides.…”

Section: Nanosonosensitizersmentioning

confidence: 99%

“…It is well known that, upon exposure to ultraviolet (UV) light, TiO 2 particles can produce electrons, which lead to the formation of ROS, such as hydrogen peroxide, hydroxyl radicals, and superoxides. Furthermore, TiO 2 was directly activated under the irradiation of UV and the potent toxicity of TiO 2 has been combined with UV irradiation for use in melanoma C32 cells in vitro [41] . Moreover, it has been shown to inhibit tumor growth in a mouse xenograft model.…”

Section: Nanosonosensitizersmentioning

confidence: 99%

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Nanosonotechnology: the next challenge in cancer sonodynamic therapy

Serpe

Foglietta

Canaparo

2012

Nanotechnology Reviews

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Sonodynamic therapy (SDT) is a newly developed anticancer treatment where ultrasound is used to trigger the cytotoxic effect of chemical compounds, known as sonosensitizers. Although SDT is similar to photodynamic therapy (PDT), SDT activates the chemical compounds through energy transfer using ultrasound rather than light. Moreover, SDT can focus the ultrasound energy onto malignant sites situated deeply within tissues, thus overcoming the main drawback linked to the use of PDT. Several physical and chemical mechanisms underlying ultrasound bioeffects and anticancer SDT take advantage of the non-thermal effect of acoustic cavitation generated by selected pulsed or continuous ultrasound. As the physical-chemical structure of the sonosentizer is essential for the success of SDT, we believe that the different aspects related to nanotechnology in medicine might well be able to improve the triggering effect ultrasound has on sonosensitizing agents. Therefore, the aim of this review is to focus on how nanotechnology might improve this innovative anticancer therapeutic approach.

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Section: Nanosonosensitizersmentioning

confidence: 99%

Section: Nanosonosensitizersmentioning

confidence: 99%

Nanosonotechnology: the next challenge in cancer sonodynamic therapy

Serpe

Foglietta

Canaparo

2012

Nanotechnology Reviews

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“…TiO2, dezenfektan, antibiyotik, biyolojik sensör, tümör hücre-ölüm ajanı ve gen hedefleme ajanı olarak araştırmalarda kullanılmaktadır [12,34]. Son yıllarda TiO2 kanser hücrelerinde uygulanmıştır [35]. Hela hücreleri (insan servikal karsinoması) üzerine titanyum dioksit denenmiştir ve hücre ölümü gözlenmiştir.…”

Section: Discussionunclassified

The Apoptotic Effects of Ti̇tani̇um Di̇oxi̇de on A549 Cells

Kaplan¹,

Çiftçi²,

Kutlu³

2017

ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology

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ÖZETMetal temelli bileşikler potansiyel etkilerinden ve az toksisiteye neden olduklarından dolayı uzun zamandır kullanılmaktadır. Metal bileşik sisplatin çeşitli kanser türlerine karşı tıbbi olarak kullanılmış ve yan etkiler göstermiştir. Bu çalışmada sisplatine alternatif ajan olarak düşünülen titanyum dioksitin A549 hücreleri üzerindeki etkileri ve apoptotik mekanizması araştırıldı. Titanyum dioksitin 24, 48 ve 72 saatlik sürelerdeki zamana ve konsantrasyon aralığına bağlı olarak antiproliferatif etkileri MTT canlılık analizi kullanılarak belirlendi. Titanyum dioksitin apoptozisi tetiklediği saptandı. Titanyum dioksitin IC30 konsantrasyonu, 72 saat süresince A549 hücreleri üzerinde uygulandığında erken ve geç apoptozisi tetiklediği belirlendi. Titanyum dioksitin IC30 konsantrasyonu, 72 saat süresince A549 hücreleri üzerine uygulandığında mitokondriyal membran potansiyelini azaltarak apoptozisi tetiklediği gösterildi. Buna rağmen kaspaz-3 aktivitesi gözlenmedi. Titanyum dioksitin IC30 konsantrasyonun 72 saatlik süre sonundaki hematoksilen ve eozin, TUNEL, BrdU, Bcl-2 ve Bax immünositokimyasal analizleri sonucunda apoptotik indekslerinde artış belirlendi. Titanyum dioksitin IC30 konsantrasyonun uygulandığı A549 hücrelerinde 72 saatlik süre sonunda konfokal ve TEM mikroskobisi kullanılarak çeşitli apoptotik yapılar gözlendi. Bu sonuçlar titanyum dioksitin A549 hücreleri üzerinde antiproliferatif ve apoptotik etkilerini ve sisplatine eş potansiyel kemoterapötik bir ajan olabileceğini göstermektedir.

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“…The PDT application of TiO 2 was first reported by Zhang et al, who demonstrated that TiO 2 NPs, under UV irradiation, are able to overcome SMMC-7721 hepatocarcinoma cancer cells by producing intra cellular ROS (9). The TiO 2 could also have an effect on the treatment of melanoma, as Harada et al showed that TiO 2 NPs, under sonodynamic therapy, could have cytotoxic effects on melanoma C32 mice cancer cells via induction of apoptosis (18). However, TiO 2 itself, due to high level of energy gap band, cannot have an effective photocatalytic impact on the presence of visible light (19) and doping TiO 2 with another PSs is an effective way to increase photocatalytic effects of TiO 2 in the visible region.…”

Section: Discussionmentioning

confidence: 99%

GO/TiO2 Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells

et al. 2016

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Photodynamic therapy (PDT) by nanoparticles (NPs) has been proposed as a new emerging therapeutic approach for the treatment of melanoma. In this study, the researchers investigate potential of photodynamic graphene oxide (GO)/TiO2 hybrid (GOT) NPs as new photosensitizers (PSs) in A375 melanoma cancer cell line. The results showed that while different concentrations of GOT NPs (1 -100 µg/mL) were inert, their irradiation with visible-light induced growth arrest and cell death in A375 cells in a dose-despondent manner. These anti-cancer effects were accompanied by significant morphological changes, suggesting GOT NPs have a potential for further evaluation as new generation of PSs for cancer therapy.

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Ultrasound activation of TiO2 in melanoma tumors

Cited by 158 publications

References 29 publications

Nanosonotechnology: the next challenge in cancer sonodynamic therapy

Nanosonotechnology: the next challenge in cancer sonodynamic therapy

The Apoptotic Effects of Ti̇tani̇um Di̇oxi̇de on A549 Cells

GO/TiO2 Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells

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