Ultrasound active nanoscaled lipid formulations for thrombus lysis

Becker, Andreas; Marxer, Elena Eva Julianne; Brüßler, Jana; Hoormann, Anne Sophia; Kuhnt, Daniela; Bakowsky, Udo; Nimsky, Christopher

doi:10.1016/j.ejpb.2010.12.003

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…Compared with the commercially available contrast agent SonoVue, the carriers exhibited adjustable properties such as small size, biocompatibility, good ultrasound reflectivity, high loading capacity, and long circulation (Figure 4(a)). Becker et al [55] investigated the ultrasound-enhanced thrombolytic effects of the different lipid dispersions (DPPC/CH, DPPC/PEG40S, DSPC/PEG40S, and the SonoVue) in human blood clots. These lipid dispersions showed a mean diameter of about 200 nm by atomic force microscopy (Figure 4(b)).…”

Section: Commonly Used Nanocarriers For Ultrasound-mediated Deliverymentioning

confidence: 99%

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Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers

Zhou

Chen

Wáng

et al. 2014

BioMed Research International

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With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. Nanocarriers, with the properties of smaller particle size, and long circulation time, would be advantageous in diagnostic and therapeutic applications. Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. The mechanisms of interaction between ultrasound and nanocarriers are not clearly understood, which may be related to cavitation, mechanical effects, thermal effects, and so forth. These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. The system has been used in various tissues and organs (in vitro or in vivo), including tumor tissues, kidney, cardiac, skeletal muscle, and vascular smooth muscle. In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers.

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Section: Commonly Used Nanocarriers For Ultrasound-mediated Deliverymentioning

confidence: 99%

“…Compared with the commercially available contrast agent SonoVue, the nanoscaled ultrasound active lipid dispersions showed good ultrasound reflectivity. (b) Visualization of diameters by atomic force microscopy [54, 55]. …”

Section: Figurementioning

confidence: 99%

Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers

Zhou

Chen

Wáng

et al. 2014

BioMed Research International

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“…for cancer therapy (Morton et al 2010). As regards the internal interventional tools, usage of microbubbles activated by external US stimulation as described in Sections 4.2.10 and 4.4.1, represents an implementation of such a merging; their potential for therapy has been recognized for a while (Mitragotri 2005) and it is a subject of on-going research (Carvell and Bigelow 2011;Becker et al 2011). In this scenario, engineered/functionalized micro/nanotools are increasingly emerging as potential players.…”

Section: Conclusion: Challenges and Opportunities For Interventionalmentioning

confidence: 99%

Removing vascular obstructions: a challenge, yet an opportunity for interventional microdevices

Miloro

Sinibaldi

Menciassi

et al. 2012

Biomed Microdevices

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Cardiovascular diseases are the leading cause of death worldwide; they are mainly due to vascular obstructions which, in turn, are mainly caused by thrombi and atherosclerotic plaques. Although a variety of removal strategies has been developed for the considered obstructions, none of them is free from limitations and conclusive. The present paper analyzes the physical mechanisms underlying state-of-art removal strategies and classifies them into chemical, mechanical, laser and hybrid (namely chemo-mechanical and mechano-chemical) approaches, while also reviewing corresponding commercial/research tools/devices and procedures. Furthermore, challenges and opportunities for interventional micro/nanodevices are highlighted. In this spirit, the present review should support engineers, researchers active in the micro/nanotechnology field, as well as medical doctors in the development of innovative biomedical solutions for treating vascular obstructions. Data were collected by using the ISI Web of Knowledge portal, buyer's guides and FDA databases; devices not reported on scientific publications, as well as commercial devices no more for sale were discarded. Nearly 70% of the references were published since 2006, 55% since 2008; these percentages respectively raise to 85% and 65% as regards the section specifically reviewing state-of-art removal tools/devices and procedures.

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“…The mechanism by which the MBs enhanced ultrasound-accelerated thrombolysis was attributed to stable and inertial cavitation as these MBs act as nuclei for cavitation decreasing the amount of energy required for the cavitation. 66 , 67 Stable cavitation leads to oscillations of MBs, resulting in micro-streaming, and therefore, erosion of clot surface which enhances the penetration of the clot by fibrinolytic enzymes. 44 Inertial cavitation is induced by increasing the acoustic power on MBs, leading to an explosion which emits the absorbed energy.…”

Section: Controlled Delivery Approaches For Tpamentioning

confidence: 99%

Tissue plasminogen activator-based clot busting: Controlled delivery approaches

El‐Sherbiny

Elkholi

Yacoub

2014

Global Cardiology Science and Practice

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Cardiovascular diseases are the leading cause of death worldwide. Thrombosis, the formation of blood clot (thrombus) in the circulatory system obstructing the blood flow, is one of the main causes behind various ischemic arterial syndromes such as ischemic stroke and myocardial infarction, as well as vein syndromes such as deep vein thrombosis, and consequently, pulmonary emboli. Several thrombolytic agents have been developed for treating thrombosis, the most common being tissue plasminogen activator (tPA), administrated systemically or locally via IV infusion directly proximal to the thrombus, with the aim of restoring and improving the blood flow. TPA triggers the dissolution of thrombi by inducing the conversion of plasminogen to protease plasmin followed by fibrin digestion that eventually leads to clot lysis. Although tPA provides powerful thrombolytic activity, it has many shortcomings, including poor pharmacokinetic profiles, impairment of the reestablishment of normal coronary flow, and impairment of hemostasis, leading to life-threatening bleeding consequences. The bleeding consequence is ascribed to the ability of tPA to circulate throughout the body and therefore can lysis all blood clots in the circulation system, even the good ones that prevent the bleeding and promote injury repair. This review provides an overview of the different delivery approaches for tPA including: liposomes, ultrasound-triggered thrombolysis, anti-fibrin antibody-targeted tPA, camouflaged-tPA, tpA-loaded microcarriers, and nano-modulated delivery approaches.

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Ultrasound active nanoscaled lipid formulations for thrombus lysis

Cited by 13 publications

References 27 publications

Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers

Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers

Removing vascular obstructions: a challenge, yet an opportunity for interventional microdevices

Tissue plasminogen activator-based clot busting: Controlled delivery approaches

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