Ultrasound and Soft-Tissue Radiography to Monitor Local Interferon-α2B Treatment in Peyronie's Disease

Andresen, Reimer; Wegner, H; Banzer, D.; Miller, K.

doi:10.3109/02841859609177665

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…followed 20 patients who received 5 weekly intralesional injections of 1 million units of interferon alpha as part of a phase 2 trial. Each patient received a baseline ultrasound, as well as one at 4 weeks and 6 months after termination of treatment [26]. The pretreatment ultrasounds demonstrated that 20% of the plaques were densely calcified, 44% were moderately calcified, and 36% were “irregular density .…”

Section: Discussionmentioning

confidence: 99%

Penile Sonographic and Clinical Characteristics in Men with Peyronie’s Disease

Smith

Brant

Fradet

et al. 2009

The Journal of Sexual Medicine

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Introduction Ultrasonography of the penis is readily available to the urologist and gives good anatomic detail of soft tissue structures. It has not been widely utilized in the assessment of Peyronie’s disease (PD). Aims To describe the sonographic characteristics of the penis in PD and the relationship between clinical and sonographic features. Methods This cross-sectional study enrolled patients from a single clinical practice. A PD-specific questionnaire was administered and sonographic evaluations were performed. Main Outcome Measures Sonographic characteristics of men with PD. Results Tunical thickening, calcifications, septal fibrosis, and intracavernosal fibrosis, were observed at initial clinical evaluation in 50%, 31%, 20%, and 15% of men, respectively. Men aged 40–49 (OR 2.4, P = 0.02) and men aged 50–59 (OR 2.4, P = 0.004) were more likely to have sub-tunical calcifications relative to men under age 40. Men with septal fibrosis had fewer chronic medical conditions such as diabetes (OR 0.3, P = 0.04), hypertension (OR 0.5, P = 0.03), and coronary artery disease (OR 0.2, P = 0.05), and presented within 1 year of disease onset (OR 2.1, P = 0.001). Men with septal fibrosis were less likely to have lost penile length (OR 0.5, P = 0.04) and more likely to be able to have intercourse (OR 1.9, P = 0.05). Men with intracavernosal fibrosis were less likely to have penile pain (OR 0.5, P = 0.05), but more likely to have penetration difficulty during intercourse (OR 1.9, P = 0.008), an additional penile deformity (OR 1.8, P = 0.02), or rapid onset of disease (OR 1.7, P = 0.04). Tunical thickening was associated with a decreased ability to have intercourse (OR 2.3, P < 0.001). Conclusion PD is a clinically and sonographically heterogeneous condition. Sonography is a safe, low-cost, and rapid means of objectively characterizing lesions in this condition. This may help track the evolution of the condition in individual patients and in the future may be useful for tailoring treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Penile Sonographic and Clinical Characteristics in Men with Peyronie’s Disease

Smith

Brant

Fradet

et al. 2009

The Journal of Sexual Medicine

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“…The other factor is the contribution of calcification into the plaque. In previous studies, it was suggested the degree of calcification could be associated with the response to conservative treatment 12,13 . However, no studies could be found to support the idea that larger plaques could have more calcium deposits.…”

Section: Discussionmentioning

confidence: 98%

Outcome analysis for conservative management of Peyronie's disease

et al. 2006

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Background:We retrospectively analysed the outcomes of conservative management of Peyronie's disease and determined the factors predicting successful outcome. Methods: The study involved 31 patients with Peyronie's disease who were treated at our institute between 1985 and 2003. We assessed the efficacy of vitamin E for the improvement of the symptoms, and the factors which contributed to successful outcome with conservative management using multivariate analysis. Results: There was no statistically significant difference in the relief rate between the vitamin E and no-medication groups. The overall estimated relief rate was 67.5% at 2 years from presentation. The multivariate analysis revealed plaque size to be the only significant factor predicting the relief from all symptoms in patients with conservative management. The rate was 100% in patients having a plaque size of 20 mm or smaller and 20.0% in those having a size of larger than 20 mm (P = 0.005). Conclusions:We could not confirm the benefit of vitamin E for Peyronie's disease. Plaque size was the only significant factor predicting the relief from all symptoms. Patients with larger plaque might fail to respond to the conservative management.

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“…Similarly, Andresen et al. compared penile ultrasonography and soft‐tissue radiography to make objective assessments in response to intralesional IFN α‐2b injections [26]. However, these authors neglected to detect plaque without calcification and to measure penile blood flow.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Intralesional Interferon α–2b Injection Therapy on Penile Hemodynamics in Men with Peyronie’s Disease

Kendirci

Usta

Matern

et al. 2005

The Journal of Sexual Medicine

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Introduction Penile duplex Doppler ultrasound (PDDU) is currently the preferred method for the functional evaluation of penile hemodynamics. PDDU may be used to monitor objectively changes in penile vascular parameters in men who undergo treatment for Peyronie’s disease (PD), including intralesional interferon alpha–2b (IFN α–2b). Aim To investigate the impact of intralesional IFN α–2b therapy for PD on penile hemodynamics by using PDDU and to assess the objective role of PDDU in monitoring treatment outcomes. Materials and Methods Thirty–nine patients (20 in the placebo and 19 in the IFN α–2b treatment arm) were enrolled in this prospective, placebo–controlled, parallel study. Patients received either 10 mL saline or 5 × 106 units of IFN α–2b intralesional injections every other week for a total of six injections. Patients in each group were evaluated at baseline and after completion of treatment regarding changes in penile hemodynamic parameters, penile curvature, plaque size and density, pain on erection, and erectile function. Specific published criteria were used for PDDU measurements. Outcomes were statistically compared between each group by using Mann–Whitney U and chi–square tests. Results The mean age of the patients and the duration of PD were similar in both groups. The improvement in penile blood flow was significantly greater in IFN α–2b–treated patients than those in the placebo group. The number with the nonvascular classification increased significantly in the IFN α–2b arm from 31.5% to 57.8%. Additionally, improvements in penile curvature, plaque size and density, and pain on erection were better in the IFN α–2b group compared with the control. No significant improvement was observed in the erectile function domain in either group. Conclusion This study reveals that intralesional IFN α–2b injections have a significant benefit on penile hemodynamic parameters. Moreover, intralesional IFN α–2b is an effective, minimally invasive treatment for PD, and PDDU is a useful adjunct to monitor objectively changes in penile vascular parameters.

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Ultrasound and Soft-Tissue Radiography to Monitor Local Interferon-α2B Treatment in Peyronie's Disease

Cited by 7 publications

References 3 publications

Penile Sonographic and Clinical Characteristics in Men with Peyronie’s Disease

Penile Sonographic and Clinical Characteristics in Men with Peyronie’s Disease

Outcome analysis for conservative management of Peyronie's disease

The Impact of Intralesional Interferon α–2b Injection Therapy on Penile Hemodynamics in Men with Peyronie’s Disease

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