Ultrasound as a Biomarker in Rheumatic Diseases

Quin, Kai; Madhoun, Hareth

doi:10.3390/diagnostics10110933

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…Musculoskeletal ultrasound has been widely used in the diagnosis of shoulder joint diseases [11][12][13][14][15]. Ultrasound has diagnostic value for PMR according to the PMR classi cation criteria issued by the 2012 EULAR Executive Committee and the ACR [5].…”

Section: Discussionmentioning

confidence: 99%

Ultrasonic Identification of Polymyalgia Rheumatica and Frozen Shoulder

LIU

Yan

SUN

et al. 2023

Preprint

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Objective/Background: Polymyalgia rheumatica (PMR) shoulder involvement and frozen shoulder (FS) are two diseases with similar clinical features. In this study, the shoulder joint ultrasound of patients with PMR and FS was analysed to explore the differential diagnosis of the two ultrasound imaging problems. Methods: PMR patients diagnosed from July 2020 to April 2022 were reviewed, and a 1:1 case‒control study was conducted with FS patients diagnosed simultaneously according to their age±3 years. Results: The eligible samples were finally screened from 169 PMR patients and matched 1:1 from 367 FS patients according to their age ±3 years. Finally, 23 groups of patients were included, and a total of 92 shoulder joints were analysed. There were 34 females (73.91%) and 12 males (26.09%), with a mean age at inclusion of 70 [63.25, 75] years. There were significant differences in sex (P=0.017), erythrocyte sedimentation rate (p < 0.001) and C-reactive protein (p < 0.001) between the two groups. Ultrasonographic characteristics showed that the incidence of subacromial-subdeltoid (SASD) bursitis (P =0.009) in PMR patients was significantly increased. Glenohumeral (GH) synovitis was more common in FS patients (P=0.013). Axillary pouch thickness had a certain advantage in the diagnosis of FS, but not PMR, with an area under the AUC of 0.827 (P < 0.001). The cut-off value was 2.85 mm, the diagnostic sensitivity was 82.61%, and the diagnostic specificity was 78.26%. Conclusions: There were some differential differences in the ultrasound features of PMR and FS. These results may provide valuable clues for the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Ultrasonic Identification of Polymyalgia Rheumatica and Frozen Shoulder

LIU

Yan

SUN

et al. 2023

Preprint

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“…Although ARDs primarily affect the musculoskeletal system, ocular involvement often coexists due to destructive immune-mediated ocular in ammation that may be vision-threatening [5,6]. A meta-analysis showed the prevalence of ocular complications was 89% in SS, 31% in SLE, and 18% in RA [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of ocular surface involvement and systemic conditions in patients with autoimmune rheumatic diseases

Liu

Ren

et al. 2023

Preprint

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Purpose: To evaluate and explore the ocular surface involvement and systemic conditions in autoimmune rheumatic diseases (ARDs). Methods: 79 patients with ARDs were enrolled in our study, including 26 patients with rheumatoid arthritis (RA), 33 patients with systemic lupus erythematosus (SLE), and 20 patients with primary Sjögren’s syndrome (pSS). All patients underwent ocular surface evaluation, including ocular surface symptoms and signs, conjunctival impression cytology, and tear multi-cytokine detection. The systemic conditions were also collected, including disease duration and disease activity. Results: SLE patients have the shortest disease duration and nearly half of them have low disease activity, while RA patients and pSS patients have a relatively long disease duration and about 90% of them have moderate/high disease activity. The incidence of dry eye and the levels of pro-inflammatory tear cytokine in SLE patients is significantly lower than RA and pSS patients, while there was no significant difference between RA and pSS patients. However, pathologic squamous metaplasia on the ocular surface is more severe in SLE and pSS patients than RA patients. Dry eye severity in all ARDs patients was shown independent of disease activity, while the ocular surface Nelson’s grades are positively correlated with disease duration in RA patients. Conclusions: Dry eye and ocular surface inflammation persist in most ARDs patients, and do not occur in parallel with the disease activity. Other than pSS, dry eye and ocular surface squamous metaplasia also exist in SLE and RA. Therefore, all patients with ARDs require a regular ophthalmologic evaluation and topical medications.

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“…In recent decades, ultrasound (US) imaging of joints has been introduced into the diagnostic and therapeutic process. A US examination may verify the clinical assessment of affected joints and improve the management of patients with RA [4,5].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Platelet Indices and Ultrasound, Clinical, Laboratory Parameters of Disease Activity in Patients with Rheumatoid Arthritis

Targońska-Stępniak

Grzechnik

Zwolak

2021

JCM

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(1) Background: A proper assessment of disease activity is crucial for the management of a patient with rheumatoid arthritis (RA). Platelets seem to be involved in joint inflammation pathophysiology. Platelet indices (PIs) are markers of platelet activation, and include platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). The purpose of the study was to assess the relationship between PIs and disease activity markers, both systemic (clinical, laboratory) and local (ultrasound, US), in patients with RA; (2) Methods: The study group consisted of 131 consecutive RA patients. The following assessments were performed: joint counts, Disease Activity Score (DAS28), complete blood cell counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and US of 24 small joints; (3) Results: Mean values of PIs remained within the normal reference ranges. Values of PC, PCT, PDW were significantly associated with disease activity markers, both clinical (DAS28, joint counts) and laboratory (CRP, ESR). In patients with high disease activity, PC, PCT were significantly higher and PDW lower. PC was positively correlated with Power Doppler US (PDUS) score. In patients with features of RA severity (antibodies positivity, extra-articular manifestations) PC and PCT were positively associated with all US parameters (Grey Scale US, PDUS, Global scores); (4) Conclusions: In patients with RA, PC and PCT may serve as positive disease activity markers and PDW may serve as a negative marker. PIs may be used as reliable, inexpensive markers of RA systemic activity; they may also serve as markers of local inflammation in the joints affected by RA.

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Ultrasound as a Biomarker in Rheumatic Diseases

Cited by 6 publications

References 59 publications

Ultrasonic Identification of Polymyalgia Rheumatica and Frozen Shoulder

Ultrasonic Identification of Polymyalgia Rheumatica and Frozen Shoulder

Evaluation of ocular surface involvement and systemic conditions in patients with autoimmune rheumatic diseases

The Relationship between Platelet Indices and Ultrasound, Clinical, Laboratory Parameters of Disease Activity in Patients with Rheumatoid Arthritis

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