Water is a limited resource that is essential for long-term development. In recent years, industrialization has exponentially increased; the pharmaceutical industry has highly profitable growth while also contributing to environmental damage. Many Pharmaceutical industry discharges wastewater into the surrounding containing complex persistent organic compounds which are highly harmful to aquatic life and people’s health. Ultrasonic Cavitation is one of the methods that are used to treat wastewater and reduce the number of harmful substances that are released into the water bodies. In order to attain maximum Chemical Oxygen Demand reduction, present review demonstrates a combination of ultrasonic cavitation method using different oxidizing agents is a practical choice to decrease the hazards from wastewater discharged through pharmaceutical companies.