Ultrasound assessment of abdominal adhesions in neonates: data over dogma for re-operative timing

Vernamonti, Jack; Lotakis, Dimitra M.; Hartman, Heather; Dougherty, Danielle; Jarboe, Marcus D.

doi:10.1007/s00383-023-05430-0

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…As for the postoperative hospital stays, Sasaki et al [ 19 ] and Zhang et al [ 20 ] claimed that patients with a previous gastrectomy history didn’t prolong their postoperative hospital stays, which was opposite of other research [ 16 – 18 , 24 ]. One of the most usual reasons for converting from LC to OC was that the previous gastrectomy history might lead to adhesions [ 34 , 35 ]. If there were some important organs adhering to the LC surgical area, inserting trocars might injury the important organs, which led to a high conversion rate [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Does previous gastrectomy history affect the surgical outcomes of laparoscopic cholecystectomy?

Shu,

Wen,

2023

BMC Surg

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Purpose This current study aimed to explore whether gastrectomy history influenced surgical outcomes while undergoing laparoscopic cholecystectomy (LC). Methods The PubMed, Embase, and Cochrane Library databases were searched for eligible studies from inception to April 29, 2023. The Newcastle–Ottawa Scale (NOS) was adopted to assess the quality of included studies. The mean differences (MDs) and 95% confidence intervals (CIs) were calculated for continuous variables, and the odds ratios (ORs) and 95% CIs were calculated for dichotomous variables. RevMan 5.4 was used for data analysis. Results Seven studies enrolling 8193 patients were eligible for the final pooling up analysis (380 patients in the previous gastrectomy group and 7813 patients in the non-gastrectomy group). The patients in the gastrectomy group were older (MD = 11.11, 95%CI = 7.80–14.41, P < 0.01) and had a higher portion of males (OR = 3.74, 95%CI = 2.92–4.79, P < 0.01) than patients in the non-gastrectomy group patients. Moreover, the gastrectomy group had longer LC operation time (MD = 34.17, 95%CI = 25.20–43.14, P < 0.01), a higher conversion rate (OR = 6.74, 95%CI = 2.17–20.26, P = 0.01), more intraoperative blood loss (OR = 1.96, 95%CI = 0.59–3.32, P < 0.01) and longer postoperative hospital stays (MD = 1.07, 95%CI = 0.38–1.76, P < 0.01) than the non-gastrectomy group. Conclusion Patients with a previous gastrectomy history had longer operation time, a higher conversion rate, more intraoperative blood loss, and longer postoperative hospital stays than patients without while undergoing LC. Surgeons should pay more attention to these patients and make prudent decisions to avoid worse surgical outcomes as much as possible.

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Section: Discussionmentioning

confidence: 99%

Does previous gastrectomy history affect the surgical outcomes of laparoscopic cholecystectomy?

Shu,

Wen,

2023

BMC Surg

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Macrophage M2 polarisation empowered reduction of abdominal adhesions via recombinant human type III collagen

Lu,

Ding,

Wang

et al. 2024

Surgical Practice

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AimThis study aims to investigate the role of recombinant human type III collagen (RHC3) in preventing abdominal adhesion.Patients and MethodsThe amino acid sequence was analysed to determine the content of GPP fragments. RHC3 was co‐cultured with macrophages, and the phenotypic classification of macrophages was based on immunofluorescence detection of inducible nitric oxide synthase for M1 macrophages and arginase 1 for M2 macrophages. This approach was used to assess the impact of RHC3 on promoting M2 polarisation. Levels of inflammatory factor levels, including interleukin 1‐beta (IL‐1β), tumour necrosis factor‐alpha (TNF‐α), and IL‐10, were quantified using enzyme‐linked immunosorbent assay to evaluate the improvement in inflammatory response. The capability of RHC3 to prevent abdominal adhesions was assessed by rinsing the abdominal cavity in an animal model.ResultsRHC3 contains GPP fragments that account for over 5% of its amino acid sequence. Cell studies indicated that RHC3 induced M2 polarisation in macrophages, significantly reduced levels of pro‐inflammatory factors (IL‐1β and TNF‐α), and significantly increased levels of the anti‐inflammatory factor IL‐10. Similarly, animal studies demonstrated a significant reduction in abdominal adhesion scores.ConclusionThese results suggest that RHC3 exhibits notable inflammation‐ameliorating activity and effectively prevents abdominal adhesions when used as a lavage solution.

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Ultrasound assessment of abdominal adhesions in neonates: data over dogma for re-operative timing

Cited by 2 publications

References 15 publications

Does previous gastrectomy history affect the surgical outcomes of laparoscopic cholecystectomy?

Does previous gastrectomy history affect the surgical outcomes of laparoscopic cholecystectomy?

Macrophage M2 polarisation empowered reduction of abdominal adhesions via recombinant human type III collagen

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