Ultrasound assessment of pubertal breast development in girls: intra- and interobserver agreement

Bruserud, Ingvild Særvold; Roelants, Mathieu; Oehme, Ninnie Helén Bakken; Eide, Geir Egil; Bjerknes, Robert; Rosendahl, Karen; Júlíusson, Pétur Benedikt

doi:10.1007/s00247-018-4188-7

Cited by 10 publications

(11 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mature stage US B5 presented as a heterogeneous mass devoid of the hypoechoic center. As described previously ( 21 ), the intra-observer agreement of US B staging was “very good” (Cohen’s kappa 0.84; 95% CI, 0.78-0.91). Presence of pubic hair was defined as a score of 2 or higher according to the Tanner PH scale ( 22 ).…”

Section: Methodssupporting

confidence: 67%

“…The cohort was representative of the general Norwegian demography, having a ~90% majority Caucasian population. Agreement between the 2 breast staging methods was satisfactory, as previously described ( 7 , 21 ). Interestingly, our participants perceived US as a less invasive procedure compared to palpation, and the majority (67.3%) of the girls favored the US evaluation (our unpublished observations).…”

Section: Discussionmentioning

confidence: 55%

“…A central undertaking in the current work was the construction of reference intervals compatible with previously defined US breast stages ( 7 , 20 , 21 ). Table 1 was configured to juxtapose reference intervals for clinical Tanner B stages and US B stages.…”

Section: Discussionmentioning

confidence: 99%

“…An experienced radiologist established the US staging protocol in line with a previous study ( 20 ). Description of the morphological distinctions providing the basis for US breast staging was provided previously ( 21 ). A trained nurse performed all clinical and US evaluations, and the most mature breast was examined.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Hormone References for Ultrasound Breast Staging and Endocrine Profiling to Detect Female Onset of Puberty

Madsen

Bruserud

Bertelsen

et al. 2020

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

View full text Add to dashboard Cite

Context Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement this method. Further, previous studies have not explored the predictive value of endocrine profiling to determine female puberty onset. Objective To integrate US breast staging with hypothalamic-pituitary-gonadal hormone references and test the predictive value of an endocrine profile to determine thelarche. Design Setting and Participants Cross-sectional sample of 601 healthy Norwegian girls, age 6 to 16 years. Main outcome measures Clinical and ultrasound breast evaluations were performed for all included girls. Blood samples were analyzed by immunoassay and ultrasensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify estradiol (E2) and estrone (E1) from the sub-picomolar range. Results References for E2, E1, LH, FSH and SHBG were constructed in relation to chronological age, Tanner and US breast stages. An endocrine profile index score derived from principle component analysis of these analytes was a better marker of puberty onset than age or any individual hormone, with ROC AUC 0.91 (P<0.001). Ultrasound detection of non-palpable glandular tissue in 14 out of 264 (5.3%) girls with clinically prepubertal presentation was associated with significantly higher median serum levels of E2 (12.5 vs 4.9 pmol/L; P<0.05) and a distinct endocrine profile (arbitrary units; P<0.001). Conclusions We provide the first hormone references for use with US breast staging and demonstrate the application of endocrine profiling to improve detection of female puberty onset.

show abstract

Section: Methodssupporting

confidence: 67%

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Hormone References for Ultrasound Breast Staging and Endocrine Profiling to Detect Female Onset of Puberty

Madsen

Bruserud

Bertelsen

et al. 2020

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ultralyd kan skille fettvev fra brystkjertelvev og kan derfor vaere nyttig for pubertetsvurderingen hos overvektige jenter (9). Vi har identifisert seks ulike stadier av brystutviklingen basert på sammensetningen av fettvev, kjertelvev og bindevev (10). Pubertetsreferanse basert på ultralydundersøkelse av bryst har aldri tidligere vaert publisert.…”

Section: Ny Norsk Referanse For Pubertetsutviklingunclassified