Ultrasound-assisted bismuth nitrate-induced green synthesis of novel pyrrole derivatives and their biological evaluation as anticancer agents

Bandyopadhyay, Debasish; Mukherjee, Sanghamitra; Granados, Jose C.; Short, Johnny D; Banik, Bimal K.

doi:10.1016/j.ejmech.2012.01.055

Cited by 82 publications

(33 citation statements)

References 36 publications

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“…Several heterocyclic compounds (both synthetic and natural) are widely known and many of them possess significant biological activities [1][2][3][4][5]. In 2013, four out of top six and nine out of top twenty one highest selling drugs were small molecule heterocyclic compounds [6].…”

Section: Introductionmentioning

confidence: 99%

Dihydropyridines as Calcium Channel Blockers: An Overview

Bandyopadhyay¹,

Salazar²,

González³

2017

JAPLR

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A heartfelt tribute to the memory of Professor AsimaChatterjee, the legendary scientist-teacher-humanitarian, on the occasion of her birth centenary . AbstractCardiovascular disease remains one of the leading causes of death in the United States. It is estimated that 1 in every 3 American adults suffer from high blood pressure. Hypertension, a precursor to most cardiovascular diseases, continues to grow at an alarming rate and is seldom managed carefully. Attempts have been made to manage hypertension and reduce the morbidity and mortality of the cardiovascular organ through methods including diets, increased amount of exercise, and medications. Many commercial drugs have been derived from dihydropyridine due to its antihypertensive property. Dihydropyridine derivatives work by acting as calcium channel blockers blocking the intake of calcium ions into the vascular smooth muscle and, to a lesser extent, cardiac muscles. Dihydropyridine moiety is well-known in pharmacology as L-type calcium channel blockers, which is extremely important since it treats hypertension in people who suffer from it. It is also highly important to understand the antagonists of calcium in the arterial hypertension. A brief overview is presented in this mini-review.

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Section: Introductionmentioning

confidence: 99%

Dihydropyridines as Calcium Channel Blockers: An Overview

Bandyopadhyay¹,

Salazar²,

González³

2017

JAPLR

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“…Pyrrole derivatives have also been reported as antimicrobial and antioxidant [15,16], anti-HIV [17], anticancer [18,19], antagonists of 5-HT7 receptor [20], antihepatitis [21], and as antifungal agents [22] as well as cognition enhancers [23] Banik et al [24] reported an expeditious synthesis of N-substituted pyrroles 1 by reacting 2,5-dimethoxy tetrahydrofuran and several amines under microwave irradiation using iodine as a catalyst. 2-Azetidinones and pyrroles are two highly important classes of molecules in organic and medicinal chemistry.…”

Section: Pyrrolesmentioning

confidence: 98%

Molecular Iodine: Mild, Green, and Nontoxic Lewis Acid Catalyst for the Synthesis of Heterocyclic Compounds

Dandia

Gupta

Maheshwari

2014

Green Chemistry: Synthesis of Bioactive Heterocycles

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The synthetic uses of molecular iodine are described. This chapter discusses the versatile uses of iodine in heterocyclic synthesis. Iodine is a universal oxidizing agent, a mild and nontoxic Lewis acid catalyst, and it catalyzes various organic reactions with high efficiency and selectivity. Also, iodine acts as an electrophile-nucleophile dual activator in the reactions. Further applications are the introduction of protecting groups, deprotection, iodocyclization, C-C bond formation, and formation of heterocycles. It is quite clear from the growing number

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“…Due to the simplicity of the procedure, the products are easily isolated and, in this case, can be directly tested for anticancer activity. Debasish Bandyopadhyay et al, on the other hand turned to eco-friendly solutions in the form of an ultrasoundassisted method in their report on the synthesis of Nsubstituted pyrroles from 2,5-dimethoxytetrahydrofuran and an array of amines, in the presence of a bismuth nitrate pentahydrate catalyst, without the necessity of using a solvent [84]. Ten pyrrole derivatives were prepared, out of which two were found to exhibit notable cytotoxicity against several cancer cell lines.…”

Section: Development Of New Compounds From Commonly Available Reagentsmentioning

confidence: 99%

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

Domagala

Jarosz

Łapkowski

2015

European Journal of Medicinal Chemistry

127

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Ultrasound-assisted bismuth nitrate-induced green synthesis of novel pyrrole derivatives and their biological evaluation as anticancer agents

Cited by 82 publications

References 36 publications

Dihydropyridines as Calcium Channel Blockers: An Overview

Dihydropyridines as Calcium Channel Blockers: An Overview

Molecular Iodine: Mild, Green, and Nontoxic Lewis Acid Catalyst for the Synthesis of Heterocyclic Compounds

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

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