Ultrasound-assisted enzymatic extraction of Corni Fructus alpha-glucosidase inhibitors improves insulin resistance in HepG2 cells

Han, Binkai; Sun, Haoqiang; Yang, Xiaolin; Wang, Ting; He, Changfen; Zhao, Ke; An, Shujing; Guo, Chen; Niu, Dou; Xue, Xiaochang; Kang, Jiefang

doi:10.1039/d1fo01002f

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…Acarbose, a common α-glucosidase inhibitor, shows a decrease in postprandial blood glucose, but it results in flatulence and abdominal pain due to the microbiota fermenting undigested carbohydrates in the large intestine [ 25 ]. Some traditional medicinal materials have demonstrated considerable α-glucosidase inhibitory activity to control high blood glucose levels [ 29 , 30 ]. In general, polyphenols (such as flavonoids and anthocyanins) were reported to be effective α-glucosidase inhibitors [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Secondary Metabolomic Analysis and In Vitro Bioactivity Evaluation of Stems Provide a Comprehensive Comparison between Dendrobium chrysotoxum and Dendrobium thyrsiflorum

et al. 2023

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The stems of Dendrobium chrysotoxum (DC) are commonly used as health-promoting foods due to their excellent biological activities. However, the stems of D. thyrsiflorum (DT) are often used to meet the scarcity of DC in production because of their highly similar morphology. However, the related metabolomic and bioactive information on the stems of DC and DT are largely deficient. Here, secondary metabolites of DC and DT stems were identified using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometry, and their health-promoting functions were evaluated using several in vitro arrays. A total of 490 metabolites were identified in two stems, and 274 were significantly different. We screened out 10 key metabolites to discriminate the two species, and 36 metabolites were determined as health-promoting constituents. In summary, DT stems with higher extract yield, higher total phenolics and flavonoids, and stronger in vitro antioxidant activities demonstrated considerable potential in food and health fields.

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Section: Discussionmentioning

confidence: 99%

Secondary Metabolomic Analysis and In Vitro Bioactivity Evaluation of Stems Provide a Comprehensive Comparison between Dendrobium chrysotoxum and Dendrobium thyrsiflorum

et al. 2023

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“…Widely targeted metabolomics technology, coupled with various chemometrics, has successfully highlighted the key differential metabolites of test materials [19,20]. In addition, a large number of in vitro assays have been developed to evaluate the bioactivities of the compounds [21,22]. To some extent, reliable detection technology and in vitro assays could help to highlight the differences between COPs and COSs.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling and Biological Activities of Pericarps and Seeds Reveal the Controversy on “Enucleation” or “Nucleus-Retaining” of Cornus officinalis Fruits

Zhang,

Niu,

et al. 2024

Molecules

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The fruits of Cornus officinalis are used not only as a popular health food to tonify the liver and kidney, but also as staple materials to treat dementia and other age-related diseases. The pharmacological function of C. officinalis fruits with or without seeds is controversial for treating some symptoms in a few herbal prescriptions. However, the related metabolite and pharmacological information between its pericarps and seeds are largely deficient. Here, comparative metabolomics analysis between C. officinalis pericarps and seeds were conducted using an ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry, and therapeutic effects were also evaluated using several in vitro bioactivity arrays (antioxidant activity, α-glucosidase and cholinesterase inhibitory activities, and cell inhibitory properties). A total of 499 secondary metabolites were identified. Thereinto, 77 metabolites were determined as key differential metabolites between C. officinalis pericarps and seeds, and the flavonoid biosynthesis pathway was identified as the most significantly different pathway. Further, 47 metabolites were determined as potential bioactive constituents. In summary, C. officinalis seeds, which demonstrated higher contents in total phenolics, stronger in vitro antioxidant activities, better α-glucosidase and butyrylcholinesterase inhibitory activities, and stronger anticancer activities, exhibited considerable potential for food and health fields. This work provided insight into the metabolites and bioactivities of C. officinalis pericarps and seeds, contributing to their precise development and utilization.

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Correlates of Rhizosphere Soil Properties, Fungal Community Composition, and Active Secondary Metabolites in Cornus officinalis in Different Regions of China

Sun

Han

Yang

et al. 2022

J Soil Sci Plant Nutr

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Ultrasound-assisted enzymatic extraction of Corni Fructus alpha-glucosidase inhibitors improves insulin resistance in HepG2 cells

Abstract: Corni Fructus (CF) is a traditional medicine and beneficial food with multifaceted protective effects against diabetes and its complications. Since alpha-glucosidase inhibitors (GI) are promising first choice oral antihyperglycemic drugs...

Cited by 5 publications

References 42 publications

Secondary Metabolomic Analysis and In Vitro Bioactivity Evaluation of Stems Provide a Comprehensive Comparison between Dendrobium chrysotoxum and Dendrobium thyrsiflorum

Secondary Metabolomic Analysis and In Vitro Bioactivity Evaluation of Stems Provide a Comprehensive Comparison between Dendrobium chrysotoxum and Dendrobium thyrsiflorum

Phytochemical Profiling and Biological Activities of Pericarps and Seeds Reveal the Controversy on “Enucleation” or “Nucleus-Retaining” of Cornus officinalis Fruits

Correlates of Rhizosphere Soil Properties, Fungal Community Composition, and Active Secondary Metabolites in Cornus officinalis in Different Regions of China

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