Ultrasound-assisted formation of tetrafluoroborate: methylene blue for microextraction and flow based spectrophotometric determination of the boron

Bayati-Comitaki, Atefe; Zahedi, Mir Mahdi

doi:10.1007/s13762-022-04278-6

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…The characteristic spectrum of MBU-EA showed no change upon sonication, indicating that water molecules are necessary for urea bond scission (Figure S24). To improve the yield of MB, a disperser solvent especially suitable for MB was added to the aqueous milieu. As expected, the yield of MB increased to a desirable ∼50% (Figure S25) at different concentrations of MBU-EA after adding a small amount of acetone (0.5–5%, v/v).…”

Section: Resultsmentioning

confidence: 99%

Urea-Bond Scission Induced by Therapeutic Ultrasound for Biofunctional Molecule Release

Tong

Huang

et al. 2022

J. Am. Chem. Soc.

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Ultrasound-triggered remote control of biomolecular functions in cells provides unique advantages for us to interrogate nature. However, strategies to design therapeutic ultrasound-responsive functional molecules remain elusive, and rare ultrasound-cleavable chemical bonds have been developed to date. Herein, therapeutic ultrasound (1 MHz)-induced scission of urea bonds for drug release is demonstrated for the first time. Such a transformation has been verified to be initiated by hydroxyl radicals generated in the interior of cavitation bubbles, occurring specifically at the cavitation bubble−liquid interface. A series of urea-bond-containing prodrugs based on methylene blue (MB), namely MBUs, are designed. Upon sonication with low-intensity therapeutic ultrasound, the urea bonds linked with primary amines can be selectively cleaved, and free MB is released in a physiologically relevant environment, accompanied by recovered absorbance, fluorescence, and photosensitivity. Moreover, an FDAapproved alkylating agent (i.e., melphalan) bearing urea bond is also developed (MBU-Mel), successfully achieving ultrasoundtriggered drug release in deep-seated cancer cells (mimic with 1 cm pigskin), showing the scalability of our ultrasound-responsive molecule platform in bioactive molecules release. This may set the starting point for therapeutic ultrasound-induced drug release, making a forward step in "sonopharmacology".

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Section: Resultsmentioning

confidence: 99%

Urea-Bond Scission Induced by Therapeutic Ultrasound for Biofunctional Molecule Release

Tong

Huang

et al. 2022

J. Am. Chem. Soc.

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“…This necessitates the development of a universal method for analyte determination. Spectrophotometry [11,12,13] and ion chromatography [14,15] are the mo s t common methods for determining tetrafluoroborate in aqueous solutions. The works [11,12] are based on the conversion of all boron forms in the sample to the BF 4 -, reaction with an organic dye, and photometric determination of the product.…”

Section: Introductionmentioning

confidence: 99%

“…Spectrophotometry [11,12,13] and ion chromatography [14,15] are the mo s t common methods for determining tetrafluoroborate in aqueous solutions. The works [11,12] are based on the conversion of all boron forms in the sample to the BF 4 -, reaction with an organic dye, and photometric determination of the product. However, the reaction s tability depends on the temperature, the sample ------------------------pH, and the dye concentration.…”

Section: Introductionmentioning

confidence: 99%

Determination of tetrafluoroborate in wastewaters by ion chromatography after ion pair liquid-liquid dispersive microextraction

Sirotkin

Elipasheva

Knyazev

et al. 2022

Anal. Method Environ. Chem. J.

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The ion chromatographic method was developed to determine tetrafluoroborate ion (BF4-) in different types of water using ion pair liquid-liquid dispersive microextraction. Tetrafluoroborate was extracted into an organic phase (1,2-dichloroethane) as an ion pair with a tetrabutylammonium cation (TBA+). The most complete formation of [(ТBА+)(BF4-)] was observed at ion-pair reagent concentration of at least 5 mmol L-1 (C(BF4-) ≤ 1mg L-1). Ultrasonic irradiation was used to disperse the extractant. The achieved concentration factor (K) was 29±3, and the degree of extraction (R) was 50±5%. The limit of detection of tetrafluoroborate using the microextraction technique was 7×10-3 mg L-1. The method applies to the analysis of different water origins. The presence of the main contained anions does not interfere with the microextraction and chromatographic determination of tetrafluoroborate. The maximum molar ratio of BF4- to diverse ions is 1:104 for fluoride, chloride, bromide, nitrate ions, and 1:102 for sulfate and perchlorate ions.

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Ultrasound-assisted formation of tetrafluoroborate: methylene blue for microextraction and flow based spectrophotometric determination of the boron

Cited by 2 publications

References 23 publications

Urea-Bond Scission Induced by Therapeutic Ultrasound for Biofunctional Molecule Release

Urea-Bond Scission Induced by Therapeutic Ultrasound for Biofunctional Molecule Release

Determination of tetrafluoroborate in wastewaters by ion chromatography after ion pair liquid-liquid dispersive microextraction

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