Ultrasound-assisted green bromination of N-cinnamoyl amino acid amides – Structural characterization and antimicrobial evaluation

Stoykova, Boyka; Chochkova, Maya; Ivanova, Galya; Маркова, Н.; Enchev, Venelin; Tsvetkova, Iva; Najdenski, Hristo; Štícha, Martin; Milkova, Tsenka

doi:10.1016/j.molstruc.2017.01.056

Cited by 2 publications

(2 citation statements)

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“…A stoichiometric amount of lithium chloride has been used to speed up and improve the conversion of the α ‐bromination of ketones, or alternatively, lithium bromide can be used as bromide source [41a,44] . Tetrabutylammonium bromide (TBAB) also improved the reaction due to its properties as a phase‐transfer catalyst, [45] and so did ultrasound [46] and zeolites [47] . A well‐known and environmentally friendly catalytic method for inducing radical reaction is through photo‐irradiation, although multiple equivalents of bromide and hydrogen peroxide can still be needed to ensure a good bromination yield [48] .…”

Section: Peroxidesmentioning

confidence: 99%

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Bromide Oxidation: A Safe Strategy for Electrophilic Brominations

2022

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Bromination of organic substances is still an important reaction in modern synthetic chemistry. In view of the increasing demand for sustainable synthetic chemistry, oxidative bromination can play an important role to avoid the use of hazardous molecular bromine (Br 2 ). In this review, a complete overview of the chemical oxidants will be provided which have been used for the electrophilic as well as radical brominations, starting from less hazardous bromide Br(À I); e. g., HBr or a bromide salt, with a focus on the differences caused by the choice of oxidant.

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Section: Peroxidesmentioning

confidence: 99%

“…Hydrogen peroxide has been successfully used to oxidatively brominate (di)ketones, [44,50] arenes, both through electrophilic ring bromination [35– 39,41b,45,48–,50d,51] and radical side‐chain bromination, [36,52] heteroarenes, [40,51b] and unsaturated bonds [28a,46,49– 50d,53] …”

Section: Peroxidesmentioning

confidence: 99%