Ultrasound-assisted preparation of ‘Ready-to-use’ extracts from Radix Paeoniae Rubra with natural deep eutectic solvents and neuroprotectivity evaluation of the extracts against cerebral ischemic/ reperfusion injury

Yu, Zhao; Wan, Haofang; Yang, Jiehong; Huang, Yan; Li, Chang

doi:10.1016/j.ultsonch.2022.105968

Cited by 15 publications

(4 citation statements)

References 30 publications

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“…On the basis of previous literature (Zhao et al ., 2022), eight natural deep eutectic solvents were selected and prepared by both conventional heating (Δ), according to the method proposed by Dai et al . (2013), and under microwave activation, following the method of Souza et al .…”

Section: Methodsmentioning

confidence: 99%

“…On the basis of previous literature (Zhao et al, 2022), eight natural deep eutectic solvents were selected and prepared by both conventional heating (Δ), according to the method proposed by Dai et al (2013), and under microwave activation, following the method of Souza et al (2022), slightly modified. In Table 1, the corresponding HBAs and HBDs used, their molar ratio, preparation time, and related NADES name abbreviations are reported.…”

Section: Nades Preparationmentioning

confidence: 99%

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In situ NADES microwave‐mediated extraction of bioactive compounds from Beta vulgaris L. var. rubra waste

Caviglia,

Russo,

Preda

et al. 2024

Int J of Food Sci Tech

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SummaryThe research focused on the recovery of bioactive compounds from beetroot waste (fresh stalks) using an innovative and microwave‐mediated (mw) procedure that could allow the simultaneous eutectic solvent preparation and matrix extraction (in situ mw NADES extraction), as a simplification of more conventional NADES (natural deep eutectic solvents) extractions. The main goal was to propose a fast and simple “one‐pot” extractive approach to obtain and screen non‐toxic, bioactive ready‐to‐use ingredients, potentially useful in food, cosmetic and pharmaceutical fields, meanwhile converting beetroot residues, from worn‐out plant matrices to recycled sources with significant added values. With this purpose, several eutectic mixtures of natural food‐grade hydrogen bond donors (choline chloride or betaine) and hydrogen bond acceptors (fructose, urea, citric acid, and glycerol) were selected and investigated (in opportune ratios) under microwave activation, considering time, temperature, and solvent‐to‐matrix ratio as the influencing variables and the total phenols content recovery as the response. By the in situ NADES microwave method developed, the best results were obtained within 5 min at 70 °C with recoveries of around 0.5 mg of polyphenols for gram of fresh stalks, assessed by the Folin–Ciocalteu test. The suitability of the NADES‐based extractives, as radical scavenging agents, was evaluated using the DPPH assay, which highlighted their good antioxidant activity; moreover, monitoring the betacyanin content by means of UV–vis spectrophotometric analyses, it was evident that NADES provide a relevant stability to the new complexes (up to 3 months) compared to water (24 h). The new in situ process proposed could be also useful for preliminary screenings of different organic matrices, simplifying workup, streamlining the procedures, and reducing costs.

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Section: Methodsmentioning

confidence: 99%

Section: Nades Preparationmentioning

confidence: 99%

In situ NADES microwave‐mediated extraction of bioactive compounds from Beta vulgaris L. var. rubra waste

Caviglia,

Russo,

Preda

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…The MCAO/R model was operated following Longa's method with slight modifications. 36 A neurological function deficit assessment method was established according to previously described methods. 37,38 The scoring criteria were as follows: 0, no symptoms of nerve damage; 1, rats cannot extend the ischemia contralateral forelimb; 2, rats turned to the contralateral side when crawling forward; 3, rats collapsed to the opposite side at rest; and 4, rats lost consciousness and could not be revived.…”

Section: Methodsmentioning

confidence: 99%

Section: 82mentioning

confidence: 99%

Optimization of smashing tissue and ultrasonic extraction of tanshinones and their neuroprotective effect on cerebral ischemia/reperfusion injury by inhibiting parthanatos

Huang

Jin

et al. 2022

Food Funct.

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Acidic natural deep eutectic solvents as dual solvents and catalysts for the solubilization and deglycosylation of soybean isoflavone extracts: Genistin as a model compound

Chen

Zhang

et al. 2023

Food Chemistry

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Ultrasound-assisted preparation of ‘Ready-to-use’ extracts from Radix Paeoniae Rubra with natural deep eutectic solvents and neuroprotectivity evaluation of the extracts against cerebral ischemic/ reperfusion injury

Cited by 15 publications

References 30 publications

In situ NADES microwave‐mediated extraction of bioactive compounds from Beta vulgaris L. var. rubra waste

In situ NADES microwave‐mediated extraction of bioactive compounds from Beta vulgaris L. var. rubra waste

Optimization of smashing tissue and ultrasonic extraction of tanshinones and their neuroprotective effect on cerebral ischemia/reperfusion injury by inhibiting parthanatos

Acidic natural deep eutectic solvents as dual solvents and catalysts for the solubilization and deglycosylation of soybean isoflavone extracts: Genistin as a model compound

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