2022
DOI: 10.1002/jhet.4527
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Ultrasound assisted synthesis of 5–7 membered heterocyclic rings in organic molecules

Abstract: Ultrasound synthesis is a powerful technique that is being used increasingly to accelerate organic reactions as a green synthetic approach. Ultrasonication has offered advantages over conventional methods in terms of enhanced yields, shorter reaction time, high selectivity and minimal side reaction. The current investigation is the review of papers published from 2016 to 2022 for the synthesis of organic heterocycles under the effect of ultrasound irradiation. It is a comprehensive compilation of sonochemical … Show more

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Cited by 23 publications
(8 citation statements)
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References 116 publications
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“…Formaldehid yang digunakan tidak memiliki atom karbon alfa dan hanya memiliki dua atom hidrogen. Sifat tersebut menyebabkan formaldehid bersifat aldehida elektrofilik dibandingkan keton karena hidrogen dapat menggantikan salah satu gugus alkil yang ada [16]. Reaksi Mannich dapat dilakukan pada kondisi alkali, netral, atau asam.…”
Section: Pendahuluanunclassified
See 1 more Smart Citation
“…Formaldehid yang digunakan tidak memiliki atom karbon alfa dan hanya memiliki dua atom hidrogen. Sifat tersebut menyebabkan formaldehid bersifat aldehida elektrofilik dibandingkan keton karena hidrogen dapat menggantikan salah satu gugus alkil yang ada [16]. Reaksi Mannich dapat dilakukan pada kondisi alkali, netral, atau asam.…”
Section: Pendahuluanunclassified
“…Tahapan berikutnya adalah penstabilan kerangka aromatik serta gugus O-H pada kerangka fenol yang bermuatan positif melalui penambahan basa membentuk lignosulfonat teraminasi 9. Lignosulfonat teraminasi hasil sintesis kemudian dikarakterisasi menggunakan FTIR dan IFT [16]. Hasil spektrum FTIR tersebut dapat digunakan untuk mengetahui jenis gugus fungsi yang ada pada lignosulfonat teraminasi hasil sintesis.…”
Section: Pembentukan Kation Iminiumunclassified
“…One of the major reasons to design coumarin derivatives containing the 1,3-dicarbonyl moiety in this study was their varied pharmacological activities, such as antioxidant, antiviral, immunomodulatory, and anti-inflammatory properties, as described in Figure 1 [ 11 , 12 , 13 ]. β-diketones are common scaffolds that can be found in many natural products and have a variety of biological functions.…”
Section: Introductionmentioning
confidence: 99%
“…This technique offers a fast, efficient and economic procedure for the synthesis of bioactive molecules in good yields within a short amount of time [19]. In contrast to conventional heating techniques or systems involving catalysts, ultrasound radiation accelerates the rate of various chemical reactions through the phenomenon of cavitation [20,21]. The bubbles produced during the cavitation phenomenon collapse with the sound waves, generating a tremendous amount of energy and transforming kinetic energy into heating energy [22].…”
Section: Introductionmentioning
confidence: 99%