Ultrasound‐Assisted Synthesis of 6‐Methyl‐1,2,3,4‐tetrahydro‐N‐aryl‐2‐oxo/thio‐4‐arylpyrimidine‐5‐carboxamides Catalyzed by Uranyl Nitrate Hexahydrate

Abstract

An efficient and simple method developed for the synthesis of 6-methyl-1,2,3,4-tetrahydro-N-aryl-2oxo/thio-4-arylpyrimidine-5-carboxamide derivatives (4a-o) using UO 2 (NO 3 ) 2 .6H 2 O catalyst under conventional and ultrasonic conditions. The ultrasound irradiation synthesis had shown several advantages such as milder conditions, shorter reaction times and higher yields. The structures of all the newly synthesized compounds have been confirmed by FT-IR, 1 H NMR, 13 C NMR and mass spectra. Article Venkatesan et al. 9.87 (s, 1H, NH), 9.37 (s, 1H, NH), 7.56 (d, 1H, J = 2.0 Hz, m-ArH of phenyl ring), 7.51 (d, 3H, J = 8.5 Hz, o,o¢ & m¢-ArH of phenyl ring), 7.39 (d, 1H, J = 8.5 Hz, o¢-ArH of phenyl ring), 7.26 (t, 2H,