Ultrasound-assisted synthesis of pyrimidines and their fused derivatives: A review

Efficient Ultrasound-Assisted Approach to N-Benzensulfonyl Phenylacetamide via CuSO4/NaAsc Catalysis in Water and Its Inhibition Activity of Seed Germination

“…并且发 现当 CuSO 4 的用量降低一倍时收率不变(Entry 9), 当降 至 0.02 equiv.时收率下降到 71% (Entry 10). 为了进一步 提高反应效率和收率, 我们发现超声辐射 [27] (广泛用于 药物分子合成)20 min 后即可完成, 且收率达到 95% (Entry 11), 相对室温磁力搅拌反应收率和效率均大幅 提高. 进而考察了不同的催化剂(Entries 11～17) [25][26]28] , 发现 CuSO 4 (Entry 11)和 CuSO [29] .…”

Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles

“…Several review articles demonstrated the application of ultrasound irradiation in diverse synthetic organic transformations. 41–52 Banerjee summarized the ultrasound-assisted organic reactions under catalyst-free conditions in 2017. 53 To our delight, no review articles existed for the transition-metal-free synthesis of diverse heterocyclic compounds based on the sonochemical activation approach.…”

Substituent-Driven Selective N-/O-Alkylation of 4-(Trihalomethyl)pyrimidin-2(1H)-ones Using Brominated Enones

“…Pyrimidines and pyrimidin-2­(1 H )-ones have been used as suitable starting materials for the synthesis of novel scaffolds that are parents of derivatives of DNA bases with possible biological and/or pharmacological properties that such novel synthetic compounds may present. − For example, trihalomethyl-substituted pyrimidines have been used as caspase and hepatitis C , inhibitors, as well as in drugs with antiplasmodial, NTPDase inhibitory, and anticancer effects.…”