2010
DOI: 10.1161/strokeaha.110.595348
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Ultrasound-Assisted Thrombolysis for Stroke Therapy

Abstract: Background and Purpose-Ultrasound has been shown to increase recombinant tissue plasminogen activator thrombolysis through stable cavitation, or sustained bubble activity, but this mechanism needs further optimization. Use of low-frequency ultrasound in combination with microbubbles stabilized against dissolution, in the form of ultrasound contrast agents, has resulted in greater lytic efficacy in vitro. Summary of Review-This article reviews the motivation for developing ultrasound-enhanced thrombolysis and t… Show more

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Cited by 71 publications
(41 citation statements)
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“…[59][60][61][62] Cavitation has been associated with enhanced thrombolysis, sonoporation, drug release, and drug delivery across the blood-brain barrier. [63][64][65][66] ELIPs have also been investigated as a cavitation nucleation agent in addition to their role as a diagnostic ultrasound contrast agents.…”
Section: Discussionmentioning
confidence: 99%
“…[59][60][61][62] Cavitation has been associated with enhanced thrombolysis, sonoporation, drug release, and drug delivery across the blood-brain barrier. [63][64][65][66] ELIPs have also been investigated as a cavitation nucleation agent in addition to their role as a diagnostic ultrasound contrast agents.…”
Section: Discussionmentioning
confidence: 99%
“…In other studies, continuous exposure to 2-MHz US alone had a signal-of-efficacy on recanalization rate and clinical outcomes, indicating that US might work even without tPA [15,16]. In addition, reduction of infarct volume by means of combined high-frequency US and microbubbles has been reported in a MCAO rat model [17,18]. However, whether high-frequency US alone is effective in reducing ischemic brain damage without any harmful effects has not yet been assessed in an animal ischemic stroke model.…”
Section: Introductionmentioning
confidence: 90%
“…Mechanical dissociation of clot [39] or use of ultrasound methods [40] are proposed in some of the literatures. Continues monitoring with transcranial Doppler (TCD) in combination with tPA therapy show higher recanalization rate than tPA without the use of TCD [41].…”
Section: Thrombolysis Improving Strategiesmentioning
confidence: 99%