Ultrasound Contrast Agents: Development of the Field and Current Status

Klibanov, Alexander L.

doi:10.1007/3-540-46009-8_3

Cited by 111 publications

(104 citation statements)

References 86 publications

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“…Ultrasound contrast agents [104] (UCA) are widely used in medical imaging with ultrasound, e.g. to enhance endocardial border delineation and to quantify organ perfusion.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound contrast agents : dynamics of coated bubbles

Overvelde¹

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“…Ultrasound contrast agents [104] (UCA) are widely used in medical imaging with ultrasound, e.g. to enhance endocardial border delineation and to quantify organ perfusion.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound contrast agents : dynamics of coated bubbles

Overvelde¹

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“…Ultrasound contrast agents are typically gas microbubbles encapsulated by a protein, polymer, or lipid shell (for review, see [2]). Targeted microbubbles are created by attaching a targeting ligand (such as a monoclonal antibody or a peptide) specific for the desired (endothelial) marker onto the shell of the microbubbles.…”

Section: Introductionmentioning

confidence: 99%

Deformable gas-filled microbubbles targeted to P-selectin

Rychak

Lindner

Ley

et al. 2006

Journal of Controlled Release

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116

104

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Ultrasound contrast microbubbles have been successfully targeted to a number of intravascular disease markers. We hypothesized that targeted delivery could be improved further, by making the microbubbles deformable, leading to increased microbubble-endothelium adhesion contact area and stabilized adhesion. Activated leukocytes utilize such strategy; they deform after binding to inflamed endothelium in the vasculature. Lipid-shell microbubbles were targeted to the endothelial inflammatory protein P-selectin with a monoclonal anti-P-selectin antibody attached to the microbubble shell. Deformable microbubbles were created by controlled pressurization with partial gas loss, which generated an average excess shell surface area of ∼30% and the formation of outward-projected wrinkles and folds. Targeted microbubble adhesion and deformability were assessed in the parallel plate flow chamber under shear flow. Sustained adhesion of deformable microbubbles at wall shear stresses between 0.4 and 1.35 dyn/cm 2 was consistently better than adhesion of wrinkle-free microbubbles. Over this shear range, targeted wrinkled microbubbles were deformed by shear flow, unlike wrinkle-free microbubbles. In a murine cremaster inflammation model, a significant improvement of deformable microbubble targeting was observed by intravital microscopy. Overall, the mechanical aspects of adhesion, such as particle shape, deformability and surface microstructure, are important in engineering efficient site-targeted particle-based agents for medical imaging and therapy.

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“…Interest in them ranges from geophysics, where bubbles might lead to volcanic eruptions [9][10][11][12] to the medical consequences of bubble formation in the blood and tissues during decompression disease [13,14]. Technological applications for bubbles are also abundant, such as ultrasound contrast agents [15], targeted drug delivery [16], biomass reactors [17] or treatment of residues [18].…”

Section: In Physical Sciences and Industrymentioning

confidence: 99%

“…glass [19][20][21], plastics [22][23][24][25], metals [26] or some kinds of volcanic rock [27]) or otherwise formed by an explosive event which temporarily fluidized the solid. Bubbles surrounded by gas must be separated from it by a thin material, like a lipid or polymer shell or a soap film [15]. Those in a liquid are the most common type and can have either a separating shell or a direct interface with their encompassing medium.…”

Section: In Physical Sciences and Industrymentioning

confidence: 99%

Growing bubbles and freezing drops: depletion effects and tip singularities

Puente¹

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Ultrasound Contrast Agents: Development of the Field and Current Status

Cited by 111 publications

References 86 publications

Ultrasound contrast agents : dynamics of coated bubbles

Ultrasound contrast agents : dynamics of coated bubbles

Deformable gas-filled microbubbles targeted to P-selectin

Growing bubbles and freezing drops: depletion effects and tip singularities

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