Ultrasound‐Controlled Electron‐Phonon Coupling Augmenting Catalysis of Piezoelectric‐Based Sonosensitizer Safely Against Osteomyelitis

Fu, Junjie; Wu, S. L.; Zhu, Shengli; Zheng, Yufeng; Jiang, Hui; Wang, Dongbin; Li, Zhaoyang; Cui, Zhenduo; Liu, Xiangmei

doi:10.1002/adfm.202304162

Cited by 14 publications

(1 citation statement)

References 53 publications

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“…To overcome this challenge, sonodynamic therapy (SDT) can be employed, which uses ultrasound as the excitation source. [18][19][20][21] The fundamental concept behind SDT closely mirrors that of PDT. After the absorption of energy from the ultrasound by the sonosensitizer (SS), an electron and energy transfer process occurs, similar to the photodynamic process, ultimately leading to the generation of reactive oxygen species (ROS) and the subsequent elimination of deep-seated tumor cells within the tissue.…”

Section: Introductionmentioning

confidence: 99%

Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death

Zhao,

Yu,

Zhang

et al. 2024

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The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) therapeutic agents generate reactive oxygen species through photo/ultrasound activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting in the death of tumor cells. The presented comprehensive review delves into recent advancements in AIE therapeutic agents designed to trigger RCD or synergize with RCD inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic cell death, autophagy, ferroptosis, and cuproptosis. Additionally, the intricate regulatory mechanisms through which activatory‐AIE therapeutics influence distinct RCD pathways are examined. A forward‐looking perspective on future developments and pertinent challenges within this exciting realm is presented, anticipating the continued evolution of activatable AIE therapeutics as a transformative approach to enhance tumor therapy.

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Section: Introductionmentioning

confidence: 99%

Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death

Zhao,

Yu,

Zhang

et al. 2024

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Low‐Dose Cu Ions Assisted by Mild Thermal Stimulus Inducing Bacterial Cuproptosis‐Like Death for Antibiosis and Biointegration

Xue,

Zhang,

Zhou

et al. 2023

Adv Funct Materials

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Methicillin‐resistant Staphylococcus aureus (MRSA) is threatening human health due to its resistance to multiple antibiotics. Excessive copper (Cu) ions target the lipoylated proteins of tricarboxylic acid cycle of cancer cells, inducing proteotoxic stress and their cuproptosis death. Whether cuproptosis plays a part in killing MRSA by low‐dose supplement of Cu ions remains to be explored. Herein, Cu‐doped hydroxyapatite nanorods (PC) are prepared on polyetheretherketone (PEEK) to resist infection and improve PEEK performance in tissue integration with the assistance of near‐infrared (NIR) irradiation, and the mechanism against MRSA is elucidated. Mild photothermal stimulation increases bacterial membrane permeability, accelerating Cu ions’ intake and consequently inducing cuproptosis‐like death of MRSA. It is confirmed by aggregation of dihydrolipoamide S‐acetyltrans‐ferase (DLAT), deactivation of glutathione peroxides 4 (GPX4), and destabilization of Fe─S cluster proteins ferredoxin (FDX1) and lipoyl synthase (LIAS). Fortunately, fibroblast behaviors are upregulated on NIR‐irradiated PC. In vivo, PC with NIR irradiation exhibits outstanding MRSA elimination, reduced inflammation response, and improved biointegration. Overall, it is demonstrated that bacterial cuproptosis‐like death can be induced by Cu ions at a non‐cytotoxic dose when cooperated with mild heat stimulus, and this photothermal strategy of PC has greatly promising application in improving PEEK performance in clinic.

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A Smart Nanovector of Cationic Starch Modified Curcumin with Excellent Targeting and Sonodynamic Properties for Effective Therapy of MRSA‐Induced Osteomyelitis

Chen,

Yang,

Mao

et al. 2023

Adv Funct Materials

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Drugs treatment including antibiotics or herbal medicines cannot cure osteomyelitis effectively accompanied by drug‐resistance bacteria and even amputation after long‐term debridement. Herein, a materioherbological strategy is utilized to construct a smart nanovector of cationic starch (CS) modified curcumin nanoparticles (CS@Cur NPs) for treating methicillin‐resistant Staphylococcus aureus (MRSA) induced osteomyelitis. On the one hand, CS modification can reduce the π–π accumulation of curcumin to endow the nanocomposite with excellent water solubility. On the other hand, the hydroxyl group in the curcumin is hydrogen‐bonded to the carbonyl group in the monomer (methyl methacrylate, MMA) of CS, resulting in a decrease in both the bandgap (between the highest and lowest occupied molecular orbitals, labeled as ΔE) and the S1–T1 energy gap (ΔES‐T) while the spin–orbital coupling (SOC) values increase, which benefits the formation of triplet‐state molecules under ultrasonic irradiation, significantly improving the yields of reactive oxygen species (ROS) capacity. The CS@Cur NPs nanocomposite constructed in this paper produced a large number of ROS synergic targeting effects under continuous 15 min ultrasonic irradiation, the clearance rate of MRSA infection induced osteomyelitis in rats can be as high as 99.93%. This study provides a new therapeutic strategy for the treatment of osteomyelitis induced by pathogenic bacteria.

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Ultrasound‐Controlled Electron‐Phonon Coupling Augmenting Catalysis of Piezoelectric‐Based Sonosensitizer Safely Against Osteomyelitis

Cited by 14 publications

References 53 publications

Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death

Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death

Low‐Dose Cu Ions Assisted by Mild Thermal Stimulus Inducing Bacterial Cuproptosis‐Like Death for Antibiosis and Biointegration

A Smart Nanovector of Cationic Starch Modified Curcumin with Excellent Targeting and Sonodynamic Properties for Effective Therapy of MRSA‐Induced Osteomyelitis

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