Ultrasound cyclo plasty for the management of glaucoma secondary to ocular irradiation for choroidal melanoma

Sebastiani, Stefano; Durán, M. Asencio; Lavín-Dapena, Cosme; Manzano-Muñoz, Beatriz; D'Anna-Mardero, Oriana; Cordero-Ros, Rosa; Pellegrini, Marco; Bernabei, Federico; Mercanti, Andrea; Scorcia, Vincenzo; Giannaccare, Giuseppe

doi:10.18240/ijo.2020.01.26

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…It results in local control of the disease in more than 95% of cases and in a relatively high rate of eye preservation [ 66 , 67 , 68 , 69 , 70 , 71 ]. Side effects of PBR depend mainly on the size and location of the tumour [ 72 , 73 , 74 , 75 , 76 , 77 , 78 ]. Radiation keratopathy represents a possible complication after PBR occurring in 1–11.5% of cases [ 66 , 68 , 78 , 79 ].…”

Section: Radiotherapy For Uveal Melanomamentioning

confidence: 99%

“…Side effects of PBR depend mainly on the size and location of the tumour [ 72 , 73 , 74 , 75 , 76 , 77 , 78 ]. Radiation keratopathy represents a possible complication after PBR occurring in 1–11.5% of cases [ 66 , 68 , 78 , 79 ]. Decreased corneal sensitivity up to complete anesthesia is a typical early sign of radiation keratopathy [ 80 ].…”

Section: Radiotherapy For Uveal Melanomamentioning

confidence: 99%

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Iatrogenic Ocular Surface Diseases Occurring during and/or after Different Treatments for Ocular Tumours

Giannaccare

Bernabei

Angi

et al. 2021

Cancers

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The ocular surface represents a finely regulated system that allows the protection of the eye. It is particularly susceptible to different treatments for intraocular tumours, such as uveal melanoma and conjunctival cancers. Traditionally, the management of ocular tumours depends on the characteristics of the lesion, and is based on a combination of selective surgery, topical chemotherapy, and/or radiotherapy delivered through different mechanisms (e.g., charged-particle radiotherapy or brachytherapy). Possible complications involving the ocular surface range from transient dry eye disease or keratitis up to corneal melting and perforation, which in any case deserve careful evaluation for the risk of permanent sigh-threatening complications. Clinicians involved in the management of these patients must be aware of this risk, in order to reach an early diagnosis and promptly set up an adequate treatment. The present review of the literature will summarize acute and chronic complications affecting the ocular surface following different therapies for the treatment of ocular tumours.

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Section: Radiotherapy For Uveal Melanomamentioning

confidence: 99%

Section: Radiotherapy For Uveal Melanomamentioning

confidence: 99%

Iatrogenic Ocular Surface Diseases Occurring during and/or after Different Treatments for Ocular Tumours

Giannaccare

Bernabei

Angi

et al. 2021

Cancers

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A 2-year prospective multicenter study of ultrasound cyclo plasty for glaucoma

Giannaccare

Pellegrini

Bernabei³

et al. 2021

Sci Rep

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Ultrasound cyclo plasty (UCP) is a recently developed surgical technique for glaucoma allowing a selective and controlled coagulation of the ciliary body. We herein investigated the long-term efficacy and safety of UCP for the treatment of glaucoma. This prospective study included patients with primary and secondary glaucoma. All surgeries were performed using the EyeOP1 device (Eye Tech Care, Rillieux-la-Pape, France). Sixty-six patients were included, and 60 completed regularly the 2-year follow-up. Preoperative IOP was 28.5 ± 9.6 mmHg and significantly decreased to 17.0 ± 5.4 at 2 years (p < 0.001). The daily number of both hypotensive eye drops and acetazolamide tablets decreased significantly (respectively, from 2.6 ± 1.1 to 1.7 ± 1.2 and from 0.7 ± 0.8 to 0.2 ± 0.5; both p < 0.001). At 2 years, 68.1% of patients met the definition of qualified success (IOP < 21 mmHg regardless of glaucoma medications) and 10.3% of patients met the definition of complete success (IOP < 21 mmHg without glaucoma medications). No major intra- or postoperative complications occurred; however, 15 eyes required additional glaucoma surgery. These results suggest that UCP is an effective and safe procedure to reduce IOP in glaucoma patients through a 2-year follow-up period.

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Ultrasound Cyclo-Plasty in Patients with Glaucoma: 1-Year Results from a Multicentre Prospective Study

et al. 2018

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Purpose: The aim of this study was to evaluate the safety and efficacy of ultrasound cyclo-plasty (UCP) for reducing intraocular pressure (IOP) in patients with glaucoma. Methods: This is a multicentre prospective study conducted in 3 Italian glaucoma centres. UCP was performed by EyeOP1, which delivers ultrasound beams using 6 piezoelectric transducers activated for 4/6 s (first generation) or 8 s (second generation). Primary outcomes were the mean IOP reduction and the rates of success after 1 year. Secondary outcomes were the mean IOP reduction at each follow-up, and the reduction of the number of hypotensive medications. Results: In total, 49 eyes from 47 patients were treated. One year postoperatively, the mean IOP had decreased from 27.7 ± 9.2 to 19.8 ± 6.9 mm Hg (p < 0.001), and the mean number of hypotensive drops and tablets had decreased from 3.2 and 0.5 to 2.3 and 0.2, respectively (p < 0.05). Postoperative IOP reduction was significantly related to preoperative IOP (r² = 0.5034; p < 0.0001). Second-generation probes determined a significantly higher IOP reduction (p < 0.05). Qualified success was achieved in 25 eyes (51.1%) and complete success in 21 (42.9%), while failure was recorded in 12 (24.5%). Conclusions: UCP is safe and effective for reducing IOP. The procedure determines a greater IOP reduction in patients with higher preoperative IOP. Second-generation probes improve outcomes without detrimental effects on safety.

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Ultrasound cyclo plasty for the management of glaucoma secondary to ocular irradiation for choroidal melanoma

Cited by 3 publications

References 18 publications

Iatrogenic Ocular Surface Diseases Occurring during and/or after Different Treatments for Ocular Tumours

Iatrogenic Ocular Surface Diseases Occurring during and/or after Different Treatments for Ocular Tumours

A 2-year prospective multicenter study of ultrasound cyclo plasty for glaucoma

Ultrasound Cyclo-Plasty in Patients with Glaucoma: 1-Year Results from a Multicentre Prospective Study

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