Ultrasound deep brain stimulation decelerates telomere shortening in Alzheimer's disease and aging mice

Zhang, Yaya; Pang, Na; Huang, Xiaowei; Wen, Minru; Meng, Long; Zhang, Bingchang; Jiang, Zhengye; Zhang, Jing; Zhou, Yi; Luo, Zhibing; Wang, Zhanxiang; Niu, Lili

doi:10.1016/j.fmre.2022.02.010

Cited by 9 publications

(4 citation statements)

References 61 publications

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“…In Alzheimer's disease (AD), ultrasound stimulation effectively improved spatial learning and memory ability in mice models of AD. It also significantly improved neuropsychological scores for up to 3 months in AD patients and increased the levels of brain-derived NTF (BDNF) and glial cell line-derived NTF in AD rat brain [26][27][28][29]. These findings demonstrate that TUS has significant therapeutic and rehabilitative effects, such as improving behavior, modulating neural firing activity, and increasing/decreasing disease-related protein expression, in various neurological diseases.…”

Section: Introductionmentioning

confidence: 74%

Modulation effect of non-invasive transcranial ultrasound stimulation in an ADHD rat model

Wang¹,

Wang²,

Ji³

et al. 2023

J. Neural Eng.

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Objective. Previous studies have demonstrated that transcranial ultrasound stimulation (TUS) with noninvasive high penetration and high spatial resolution has an effective neuromodulatory effect on neurological diseases. Attention deficit hyperactivity disorder (ADHD) is a persistent neurodevelopmental disorder that severely affects child health. However, the neuromodulatory effects of TUS on ADHD have not been reported to date. This study aimed to investigate the neuromodulatory effects of TUS on ADHD. Approach. TUS was performed in ADHD model rats for 2 consecutive weeks, and the behavioral improvement of ADHD, neural activity of ADHD from neurons and neural oscillation levels, and the plasma membrane dopamine transporter (DAT) and brain-derived neurotrophic factor (BDNF) in the brains of ADHD rats were evaluated. Main results. TUS can improve cognitive behavior in ADHD rats, and TUS altered neuronal firing patterns and modulated the relative power and sample entropy of local field potentials in the ADHD rats. In addition, TUS can also enhance BDNF expression in the brain tissues. Significance. TUS has an effective neuromodulatory effect on ADHD and thus has the potential to clinically improve cognitive dysfunction in ADHD.

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Section: Introductionmentioning

confidence: 74%

Modulation effect of non-invasive transcranial ultrasound stimulation in an ADHD rat model

Wang¹,

Wang²,

Ji³

et al. 2023

J. Neural Eng.

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“…For instance, engineered telomerase expression in AD mouse model ameliorates AD phenotypes via upregulating the gene networks governing synaptic signaling and learning processes, a mechanism unrelated to its catalytic activity (Shim et al., 2021 ). Using a new method to specifically decelerate TL shortening in the cortex and myocardial tissue can effectively improve cognitive performance in a mouse model of AD (APP/PS1) (Zhang et al., 2023 ), suggesting TL is indeed a determinant of AD. These results indicate that a suitable mice model that can faithfully recapitulate TL attrition seen in human AD should be established to discern the functional consequence of TL attrition to AD pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner

Guo,

Li,

et al. 2024

Aging Cell

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Although studies have demonstrated that genome instability is accumulated in patients with Alzheimer's disease (AD), the specific types of genome instability linked to AD pathogenesis remain poorly understood. Here, we report the first characterization of the age‐ and sex‐related trajectories of telomere length (TL) and micronuclei in APP/PS1 mice model and wild‐type (WT) controls (C57BL/6). TL was measured in brain (prefrontal cortex, cerebellum, pituitary gland, and hippocampus), colon and skin, and MN was measured in bone marrow in 6‐ to 14‐month‐old mice. Variation in TL was attributable to tissue type, age, genotype and, to a lesser extent, sex. Compared to WT, APP/PS1 had a significantly shorter baseline TL across all examined tissues. TL was inversely associated with age in both genotypes and TL shortening was accelerated in brain of APP/PS1. Age‐related increase of micronuclei was observed in both genotypes but was accelerated in APP/PS1. We integrated TL and micronuclei data with data on cognition performance and brain amyloidosis. TL and micronuclei were linearly correlated with cognition performance or Aβ40 and Aβ42 levels in both genotypes but to a greater extent in APP/PS1. These associations in APP/PS1 mice were dominantly driven by females. Together, our findings provide foundational knowledge to infer the TL and micronuclei trajectories in APP/PS1 mice during disease progression, and strongly support that TL attrition and micronucleation are tightly associated with AD pathogenesis in a female‐biased manner.

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“…Niu et al. [ 131 ] observed that ultrasound stimulation could delay telomere shortening in cortical and myocardial tissues and improve spatial cognition and learning in AD mouse models. Beisteiner et al.…”

Section: Ultrasound Brain Modulation and Possible Writingmentioning

confidence: 99%

The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface

et al. 2023

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A noninvasive brain–computer interface is a central task in the comprehensive analysis and understanding of the brain and is an important challenge in international brain-science research. Current implanted brain–computer interfaces are cranial and invasive, which considerably limits their applications. The development of new noninvasive reading and writing technologies will advance substantial innovations and breakthroughs in the field of brain–computer interfaces. Here, we review the theory and development of the ultrasound brain functional imaging and its applications. Furthermore, we introduce latest advancements in ultrasound brain modulation and its applications in rodents, primates, and human; its mechanism and closed-loop ultrasound neuromodulation based on electroencephalograph are also presented. Finally, high-frequency acoustic noninvasive brain–computer interface is prospected based on ultrasound super-resolution imaging and acoustic tweezers.

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Ultrasound deep brain stimulation decelerates telomere shortening in Alzheimer's disease and aging mice

Cited by 9 publications

References 61 publications

Modulation effect of non-invasive transcranial ultrasound stimulation in an ADHD rat model

Modulation effect of non-invasive transcranial ultrasound stimulation in an ADHD rat model

Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner

The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface

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