2022
DOI: 10.1016/j.bmcl.2022.128767
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Ultrasound-dependent RNAi using TatU1A-rose bengal conjugate

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Cited by 4 publications
(1 citation statement)
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“…Brock et al found that blocking the contact and fusion of endosomal bilayers containing bis(monoacylglycero)phosphate, an anionic lipid present in cell membranes, prevented the endosomal escape of Tat, suggesting that cationic peptides interact with anionic lipids to induce leakage from endosomal membranes 89 . Increasing the endosomal escape activity of CPPs is an ongoing field of research, and novel strategies such as integration of CPPs with arginine-glycineaspartate motifs 90 , coating CPP nanoparticles with metal-phenolic networks 91 , photochemical internalization treatment 92 , and the use of ultrasound to disrupt endosomal membranes and deliver small nucleic acids 93 are continuously being developed.…”
Section: Endosomal Escapementioning
confidence: 99%
“…Brock et al found that blocking the contact and fusion of endosomal bilayers containing bis(monoacylglycero)phosphate, an anionic lipid present in cell membranes, prevented the endosomal escape of Tat, suggesting that cationic peptides interact with anionic lipids to induce leakage from endosomal membranes 89 . Increasing the endosomal escape activity of CPPs is an ongoing field of research, and novel strategies such as integration of CPPs with arginine-glycineaspartate motifs 90 , coating CPP nanoparticles with metal-phenolic networks 91 , photochemical internalization treatment 92 , and the use of ultrasound to disrupt endosomal membranes and deliver small nucleic acids 93 are continuously being developed.…”
Section: Endosomal Escapementioning
confidence: 99%