Ultrasound Detection of <i>Salmonella</i> Septic Arthritis in a Rheumatoid Arthritis Patient on Anti-TNF Treatment

Nandagudi, Anupama; Kelly, Stephen

doi:10.1177/2324709614532799

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…Patients with rheumatologic disorders are at a higher risk for septic arthritis due to their damaged joints . Accordingly, up to 40% of patients with RA have history of septic arthritis . Moreover, more than 25 cases of septic arthritis have been reported in patients with SLE .…”

Section: Discussionmentioning

confidence: 99%

Rheumatologic complications in a cohort of 227 patients with common variable immunodeficiency

et al. 2018

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Common variable immunodeficiency (CVID) is the most prevalent symptomatic type of human primary immunodeficiency diseases (PID). Clinically, CVID is characterized by increased susceptibility to infections and a wide variety of autoimmune and rheumatologic disorders. All patients with CVID registered in Iranian PID Registry (IPIDR) were enrolled in this retrospective cohort study. We investigated the frequency of rheumatologic diseases and its association with immunological and clinical phenotypes in patients with CVID. A total of 227 patients with CVID were enrolled in this study. The prevalence of rheumatologic disorders was 10.1% with a higher frequency in women than men. Most common rheumatologic manifestations were juvenile idiopathic arthritis (JIA) and adult rheumatoid arthritis (RA) followed by juvenile spondyloarthritis (JSpA) and undifferentiated inflammatory arthritis (UIA). Septic arthritis in patients with CVID with a history of RA and JIA was higher than patients without rheumatologic complication. Patients with CVID with a history of autoimmunity (both rheumatologic and non-rheumatologic autoimmunity) had lower regulatory T cells counts in comparison with patients without autoimmune disorders. There was an association between defect in specific antibody responses and negative serologic test results in patients with rheumatologic manifestations. JIA, RA, JSpA and UIA are the most frequent rheumatologic disorders in patients with CVID. Due to antibody deficiency, serologic tests may be negative in these patients. Therefore, these conditions pose significant diagnostic and therapeutic challenges for immunologists and rheumatologists in charge of the care for these patients.

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Section: Discussionmentioning

confidence: 99%

Rheumatologic complications in a cohort of 227 patients with common variable immunodeficiency

et al. 2018

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“…Patients on anti-tumour necrosis factor (TNF) alpha therapy, such as infliximab,23 etanercept24 and certolizumab,25 are particularly susceptible due to reduction in the ability to kill the intracellular pathogens. The patient in our case report had been on adalimubab (Humira), a chimeric monoclonal anti-TNF antibody.…”

Section: Discussionmentioning

confidence: 99%

UnusualSalmonella typhiperiprosthetic joint infection involving bilateral knees: management options and literature review

Rajgopal¹,

Panda²,

Gupta

2017

BMJ Case Reports

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A 70-year-old Indian woman, who had undergone primary bilateral total knee arthroplasty (TKA) for rheumatoid arthritis 10 months prior, presented with 10 days history of pain, swelling and erythema over both knees with pus discharging from the right knee. She had type 2 diabetes mellitus and was on long-term steroid, leflunomide and antitumour necrosis factor therapy for rheumatoid arthritis. Her clinical and laboratory features were suggestive of a haematogenous periprosthetic joint infection (PJI). The final diagnosis of bilateral PJI was made based on culture reports. Considering her underlying immunosuppression, a bilateral two-stage revision TKA was done with complete remission of symptoms and good functional recovery at last follow-up after 18 months. infection of prosthetic joint has not been reported in the literature. Patients presenting with gastrointestinal complaints and PJI should alert the clinician to the possibility of infection with such atypical organisms endemic to the region.

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Ultrasound Detection of Salmonella Septic Arthritis in a Rheumatoid Arthritis Patient on Anti-TNF Treatment

Cited by 2 publications

References 44 publications

Rheumatologic complications in a cohort of 227 patients with common variable immunodeficiency

Rheumatologic complications in a cohort of 227 patients with common variable immunodeficiency

UnusualSalmonella typhiperiprosthetic joint infection involving bilateral knees: management options and literature review

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