Ultrasound detection of uterine abnormalities after diethylstilbestrol (DES) exposure.

Viscomi, G N; Gonzalez, R; Taylor, K. J. W.

doi:10.1148/radiology.136.3.7403556

Cited by 23 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…45 Viscomi and colleagues analyzed the echographic appearance of the uterus in cases of DES exposure. 46 An abnormal T-shape uterus was found in 3 of the 18 (16%) women exposed to DES, a percentage in agreement with an incidence of 12% observed on hysterosalpingogram (HSG). 47 Furthermore, Viscomi and colleagues reported a reduced uterine size with a mean uterine length of 6.8 ± 0.4 cm in 18 DES-exposed women as compared to 8.1 ± 0.8 cm in 20 age-matched controls, even in the absence of gross morphological anomalies.…”

Section: Anatomy and Morphological Measurementssupporting

confidence: 70%

Pelvic Imaging in Reproductive Endocrinology

Ziegler¹,

Streuli²,

Santulli³

et al. 2014

Yen &Amp; Jaffe's Reproductive Endocrinology

View full text Add to dashboard Cite

Section: Anatomy and Morphological Measurementssupporting

confidence: 70%

Pelvic Imaging in Reproductive Endocrinology

Ziegler¹,

Streuli²,

Santulli³

et al. 2014

Yen &Amp; Jaffe's Reproductive Endocrinology

View full text Add to dashboard Cite

“…The teratogenicity of estrogens on the developing uterus is well established both in laboratory animals and humans (Viscomi et al, 1980;Haney et al, 1979;Cunha et al, 1987;Kaufman et al, 1977Kaufman et al, , 1980Forsberg, 1988;Mori and Iguchi, 1988). Immediate effects of estrogens on the developing uterus include qualitative and quantitative changes in protein synthesis (Newbold et al, 1981(Newbold et al, , 1984 and stimulation of epithelial proliferation (Forsberg, 1970;Eide, 1975a,b;Bigsby and Cunha, 1986).…”

Section: Introductionmentioning

confidence: 99%

Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Brody

Cunha

1989

Am. J. Anat.

View full text Add to dashboard Cite

The effects of diethylstilbestrol (DES) treatment on myometrial development from the prenatal to adult period were examined in rats and mice by histologic and immunocytochemical methods using anti-actin, -vimentin, and -laminin to assess cytodifferentiation of smooth muscle and fibroblastic cells, and by morphometric procedures to assess quantitatively the effect of DES on the expression of cellular orientation in the emerging inner circular myometrial layer. Neonatal rats and mice were treated with DES from day 0 (day of birth) to day 2 with dosages known to perturb myometrial development. Neonatal treatment with DES increased the degree of circular orientation within the uterine mesenchyme, an effect detectable following as little as 24 hr of DES treatment. This effect on spatial organization of the mesenchyme was followed by an increase in the thickness of the actin-positive middle layer (prospective circular myometrium) of uterine mesenchyme during days 3-15; from day 15 onward, however, the circular myometrial layer began to fragment into irregular bundles of smooth muscle, and the longitudinal myometrial layer became thinner and more irregularly organized than controls. Vimentin localization in rats treated with DES neonatally was more intense than in controls within the circularly orientated uterine mesenchyme at 5 days. By 60 days the circular and longitudinal myometrial layers of DES-treated animals showed strands and bundles of vimentin-positive cells, which were not present in controls. Both rats and mice show comparable effects of DES treatment.

show abstract

“…Utenne thickness (J) was always measured by a sagittal section (cm) between the antenor and posterior walls. Uterine volume (cm 3 ) was estimated using the formula of Viscomi et al (1980) (4/3rcXL/2x W/ 2X772). By tilting the end of the vaginal probe to the rear, cervical length was measured as the distance separating the external and internal os…”

Section: Objectmentioning

confidence: 99%

Uterus and endometrium: Transvaginal ultrasound studies of vascular and morphological changes in uteri exposed to diethylstilbestrol in utero

Salle¹,

Sergeant

Awada³

et al. 1996

Human Reproduction

View full text Add to dashboard Cite

The aim of this prospective study was to establish complementary data of uteri exposed to diethylstilbestrol (DES) in utero for transvaginal analysis and vascularity changes during the menstrual cycle. A total of 28 women with DES-exposed uteri were compared with 60 non-exposed women. Transvaginal ultrasound and colour Doppler imaging were performed on days 5 and 22 of the menstrual cycle. Uteri were measured on sagittal and transverse scans. Uterine length, width, thickness and uterine cavity length and width were measured. Uterine volume and uterine cavity area were calculated. DES-exposed uterine volume was equal to 31.84 +/- 3.37 cm3. The cavity area of DES-exposed uterus was equal to 35.85 +/- 3.93 cm2. Cervix length of DES-exposed uterus was significantly smaller than that of non-exposed uterus. The uterine artery pulsatility index (PI) of DES-exposed uterus was significantly higher than that of normal uterus. Blood flow remained stable throughout the menstrual cycle. The PI of DES-exposed uterus remained stable during the menstrual cycle, as in non-exposed uterus, and it decreased during the luteal phase. This lack of modification in vascularity of DES-exposed uterus may explain miscarriages and obstetric complications such as intrauterine growth retardation or pre-eclampsia. The data may have implications for the assessment of reproductive status and the design of future studies on disorders of implantation in DES-exposed uterus.

show abstract

Ultrasound detection of uterine abnormalities after diethylstilbestrol (DES) exposure.

Cited by 23 publications

References 0 publications

Pelvic Imaging in Reproductive Endocrinology

Pelvic Imaging in Reproductive Endocrinology

Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Uterus and endometrium: Transvaginal ultrasound studies of vascular and morphological changes in uteri exposed to diethylstilbestrol in utero

Contact Info

Product

Resources

About