“…It should be noted that the data collected so far, while promising, is retrospective and cannot be applied directly to clinical work. In addition to larger training datasets, there is a need for validation studies, which may be particularly helpful for inexperienced ultrasound examiners [8]. This is of relevance since, for example, the number of diagnostic puncture procedures, such as chorionic villus sampling or amniocentesis in prenatal diagnostics, has rapidly decreased due to the optimization of non-invasive screening for trisomies [9].…”